Functional and pathological improvements of the hearts in diabetes model by the combined therapy of bFGF-loaded nanoparticles with ultrasound-targeted microbubble destruction

Journal of Controlled Release

Volumn 186, Issue , 2014, Pages 22-31

  Zhao, Ying Zheng ^a   Tian, Xin Qiao ^b   Zhang, Ming ^a   Cai, Lu ^c   Ru, Ao ^d   Shen, Xiao Tong ^a   Jiang, Xi ^a   Jin, Rong Rong ^a   Zheng, Lei ^b   Hawkins, Kyle ^c   Charkrabarti, Subrata ^e   Li, Xiao Kun ^a   Lin, Qian ^a   Yu, Wen Ze ^a   Ge, Shuping ^f   Lu, Cui Tao ^a,b   Wong, Ho Lun ^g  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c University of Louisville School of Medicine   (United States)

^d ICU   (China)

^e WESTERN UNIVERSITY   (Canada)

^f DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^g TEMPLE UNIVERSITY   (United States)

Author keywords

Basic fibroblast growth factor; Diabetic cardiomyopathy; Nanoparticle; Targeted delivery; Ultrasound targeted microbubble destruction

Indexed keywords

BIOACTIVITY; ENCAPSULATION; MORPHOLOGY; NANOPARTICLES; RATS; TISSUE; ULTRASONIC APPLICATIONS;

BASIC FIBROBLAST GROWTH FACTOR; COMBINED TREATMENT; DIABETIC CARDIOMYOPATHY; ENCAPSULATION EFFICIENCY; GROWTH FACTOR THERAPIES; TARGETED DELIVERY; THERAPEUTIC EFFECTS; ULTRASOUND-TARGETED MICROBUBBLE DESTRUCTION;

HEART;

FIBROBLAST GROWTH FACTOR 2; HEPARIN; NANOPARTICLE; POLOXAMER; COLLAGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CAPILLARY DENSITY; CONTROLLED STUDY; CYTOTOXICITY; DIABETIC CARDIOMYOPATHY; DRUG DELIVERY SYSTEM; ECHOCARDIOGRAPHY; ENCAPSULATION; HEART; HEART FUNCTION; HEART LEFT VENTRICLE; HEMODYNAMICS; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MICROBUBBLE; NONHUMAN; PARTICLE SIZE; PRIMARY CULTURE; PRIORITY JOURNAL; RAT; ULTRASOUND TARGETED MICROBUBBLE DESTRUCTION; ZETA POTENTIAL; ANIMAL; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; DRUG EFFECTS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; ULTRASOUND;

ANIMALS; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC CARDIOMYOPATHIES; FIBROBLAST GROWTH FACTOR 2; HEART; HEPARIN; MICROBUBBLES; MYOCARDIUM; NANOPARTICLES; POLOXAMER; RATS, SPRAGUE-DAWLEY; ULTRASONICS; VENTRICULAR FUNCTION, LEFT;

EID: 84901062313     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.04.054     Document Type: Article

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