Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors

Archives of Pharmacal Research

Volumn 33, Issue 10, 2010, Pages 1641-1649

  Jin, Zhe ^a,b   Yang, Liu ^a,b   Liu, Si Jie ^a,b   Wang, Jian ^a,b   Li, Shuo ^c   Lin, Huang Quan ^c   Wan, David Chi Cheong ^c   Hu, Chun ^a,b  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

1,2,4 Triazine; Acetylcholinesterase; Heterocycle; Inhibitor; Molecular docking; Molecular fields analysis; Thiazole

Indexed keywords

2 (4 BROMOPHENYL) 2 OXOACETIC ACID; 2 (4 CHLOROPHENYL) 2 OXOACETIC ACID; 2 ARYL 2 OXOACETIC ACID; 3 (4 CHLOROPHENYL) 6 (4 BROMOPHENYL) 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 (4 CHLOROPHENYL) 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 (4 HYDROXY 3 METHYLPHENYL) 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 (4 HYDROXYPHENYL) 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 (4 METHOXY 3 METHYLPHENYL) 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 (4 METHYLPHENYL) 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 [4 (2 (4 PIPERIDYL)ETHOXY)PHENYL] 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 [4 (2 DIMETHYLAMINO 2 OXOETHOXY)PHENYL] 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3 [4 (2 OXO 2 (4 MORPHOLINYL)ETHOXY)PHENYL] 6 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3,6 DIARYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 3,6 DIARYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE DERIVATIVE; 6 (4 BROMOPHENYL) 3 (4 METHOXYPHENYL) 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 6 (4 BROMOPHENYL) 3 (4 METHYLPHENYL) 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 6 (4 BROMOPHENYL) 3 THIOXO 3,4 DIHYDRO 1,2,4 TRIAZIN 5(2H) ONE; 6 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL) 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 6 (4 CHLOROPHENYL) 3 PHENYL 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; 6 (4 CHLOROPHENYL) 3 THIOXO 3,4 DIHYDRO 1,2,4 TRIAZIN 5(2H) ONE; 6 ARYL 3 THIOXO 3,4 DIHYDRO 1,2,4 TRIAZIN 5(2H) ONE; 6 PHENYL 3 (4 TERT BUTYLPHENYL) 7H THIAZOLO[3,2 B][1,2,4]TRIAZIN 7 ONE; ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; DONEPEZIL; HUPERZINE A; RIVASTIGMINE; TACRINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COLORIMETRY; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; ANIMALS; BINDING SITES; CHOLINESTERASE INHIBITORS; DATABASES, PROTEIN; GPI-LINKED PROTEINS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TORPEDO; TRIAZINES;

EID: 78449235079     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-1013-8     Document Type: Article

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