Mechanisms of toxicity of hydroxylated polybrominated diphenyl ethers (HO-PBDEs) determined by toxicogenomic analysis with a live cell array coupled with mutagenesis in escherichia coli

Environmental Science and Technology

Volumn 48, Issue 10, 2014, Pages 5929-5937

  Su, Guanyong ^a   Yu, Hongxia ^a   Lam, Michael H W ^b   Giesy, John P ^a,b,c,d   Zhang, Xiaowei ^a  

^a NANJING UNIVERSITY   (China)

^b CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXICITY; ESCHERICHIA COLI; GENE EXPRESSION; RNA; TOXICITY;

EFFECT CONCENTRATION; HYDROXYLATED POLYBROMINATED DIPHENYL ETHERS; INHIBITED GROWTH; METABOLIC PROCESS; MOLECULAR MECHANISM; MOLECULAR SIGNALING; POLYBROMINATED DIPHENYL ETHERS; TRANSCRIPTIONAL FACTORS;

ORGANIC POLLUTANTS;

2 HO BDE 123; 2' HO BDE 25; 2' HO BDE 28; 2' HO BDE 66; 2' HO BDE 68; 2' HO BDE 7; 3 HO BDE 100; 3' HO BDE 7; 4 HO BDE 90; 4' HO BDE 17; 4' HO BDE 49; 5 CL 6 HO BDE 47; 6 HO BDE 47; 6 HO BDE 85; 6 HO BDE 90; 6' CL 2 HO BDE 68; 6' HO BDE 17; BACTERIAL RNA; POLYBROMINATED DIPHENYL ETHER; RIBOSOME RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CONCENTRATION (COMPOSITION); DOSE-RESPONSE RELATIONSHIP; ECOTOXICOLOGY; FECAL COLIFORM; GENOTOXICITY; GROWTH RATE; INHIBITION; PBDE; POLLUTION EXPOSURE;

ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIOSTASIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DOWN REGULATION; ESCHERICHIA COLI; EXPOSURE; GENE CONTROL; GENE EXPRESSION; IC 50; MOLECULAR MECHANICS; MUTAGENESIS; NONHUMAN; OPERON; RRNA GENE; RRNB GENE; RRNC GENE; SENSITIVITY ANALYSIS; TOXICOKINETICS; UHPT GENE; UPREGULATION;

ESCHERICHIA COLI; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENE REGULATORY NETWORKS; GENES, BACTERIAL; HALOGENATED DIPHENYL ETHERS; HYDROXYLATION; MICROBIAL VIABILITY; MUTAGENESIS; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; TOXICOGENETICS; TRANSCRIPTION FACTORS;

EID: 84901036344     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es5003023     Document Type: Article

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