Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i

Journal of Neuroscience

Volumn 34, Issue 21, 2014, Pages 7047-7058

  Di Guilmi, Mariano N ^a   Wang, Tiantian ^b   Inchauspe, Carlota Gonzalez ^a   Forsythe, Ian D ^c   Ferrari, Michel D ^d   Van Der Maagdenberg, Arn M J M ^d   Borst, J Gerard G ^b   Uchitel, Osvaldo D ^a  

^a INSTITUTO DE FISIOLOGÍA   (Argentina)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Calyx of Held; FHM 1; In vivo; P Q calcium channels; Synaptic transmission

Indexed keywords

UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED CALCIUM CHANNEL 2.1;

ACTION POTENTIAL; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY STIMULATION; CALCIUM CURRENT; CALYX OF HELD; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; FAMILIAL HEMIPLEGIC MIGRAINE; GAIN OF FUNCTION MUTATION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; SYNAPSE; SYNAPTIC TRANSMISSION; WHOLE CELL PATCH CLAMP;

CALYX OF HELD; FHM-1; IN VIVO; P/Q CALCIUM CHANNELS; SYNAPTIC TRANSMISSION;

AGATOXINS; ANIMALS; BRAIN STEM; CALCIUM; CALCIUM CHANNELS, N-TYPE; DISEASE MODELS, ANIMAL; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIGRAINE WITH AURA; MUTATION; NEUROTOXINS; SODIUM CHANNEL BLOCKERS; SYNAPSES; TETRODOTOXIN; TIME FACTORS;

EID: 84901036315     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2526-13.2014     Document Type: Article

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