Cumulative effects of variants identified by genome-wide association studies in IgA nephropathy

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Zhou, Xu Jie ^a,b   Qi, Yuan Yuan ^a,b   Hou, Ping ^a,b   Lv, Ji Cheng ^a,b   Shi, Su Fang ^a,b   Liu, Li Jun ^a,b   Zhao, Na ^a,b   Zhang, Hong ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b Ministry of Education   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A;

ADOLESCENT; ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; CASE CONTROL STUDY; CHILD; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; INFANT; PRESCHOOL CHILD; PROCEDURES; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; INFANT; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84901036140     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04904     Document Type: Article

References (31)

1. Wyatt, R. J. & Julian, B. A. IgA nephropathy. N Engl J Med 368, 2402-14 (2013).
2. Suzuki, H. et al. The pathophysiology of IgA nephropathy. J Am Soc Nephrol 22, 1795-803 (2011).
3. Boyd, J. K., Cheung, C. K., Molyneux, K., Feehally, J. & Barratt, J. An update on the pathogenesis and treatment of IgA nephropathy. Kidney Int 81, 833-43 (2012).
4. Berthoux, F. et al. Autoantibodies targeting galactose-deficient IgA1 associate with progression of IgA nephropathy. J Am Soc Nephrol 23, 1579-87 (2012).
5. Kiryluk, K. et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genet 8, e1002765 (2012).
6. Zhao, N. et al. The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression. Kidney Int 82, 790-6 (2012).
7. Kiryluk, K., Novak, J. & Gharavi, A. G. Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies. Annu Rev Med 64, 339-56 (2013).
8. Xie, J. et al. Predicting progression of IgA nephropathy: new clinical progression risk score. PLoS One 7, e38904 (2012).
9. Hsu, S. I., Ramirez, S. B., Winn, M. P., Bonventre, J. V. & Owen, W. F. Evidence for genetic factors in the development and progression of IgA nephropathy. Kidney Int 57, 1818-35 (2000). (Pubitemid 30252274)
10. Kiryluk, K. et al. Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schonlein purpura nephritis. Kidney Int 80, 79-87 (2011).
11. Hastings, M. C. et al. Galactose-deficient IgA1 in African Americans with IgA nephropathy: serum levels and heritability. Clin J Am Soc Nephrol 5, 2069-74 (2010).
12. Yu, X. Q. et al. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. Nat Genet 44, 178-82 (2012).
13. Xie, J., Shapiro, S. &Gharavi, A. Genetic studies of IgA nephropathy: what have we learned from genome-wide association studies. Contrib Nephrol 181, 52-64 (2013).
14. Cheng, W. et al. Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese. Nephrol Dial Transplant 26, 2544-9 (2011).
15. Feehally, J. et al. HLA has strongest association with IgA nephropathy in genomewide analysis. J Am Soc Nephrol 21, 1791-7 (2010).
16. Zhou, X. J. et al. FCGR2B and FCRLB gene polymorphisms associated with IgA nephropathy. PLoS One 8, e61208 (2013).
17. Havulinna, A. S. et al. A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32, 669 individuals. Hypertension 61, 987-94 (2013).
18. Padmanabhan, S. Prospects for genetic risk prediction in hypertension. Hypertension 61, 961-3 (2013).
19. Lieb, W. et al. Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension 61, 995-1001 (2013).
20. Janssens, A. C., Ioannidis, J. P., van Duijn, C. M., Little, J. & Khoury, M. J. Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. BMJ 342, d631 (2011).
21. Janssens, A. C. et al. The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med 9, 528-35 (2007). (Pubitemid 47282041)
22. Evans, D. M., Visscher, P. M. &Wray, N. R. Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet 18, 3525-31 (2009).
23. Dudbridge, F. Power and predictive accuracy of polygenic risk scores. PLoS Genet 9, e1003348 (2013).
24. Paynter, N. P. et al. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA 303, 631-7 (2010).
25. Prahalad, S. et al. Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci. Arthritis Rheum 65, 1663-7 (2013).
26. Karlson, E. W. et al. Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. Ann Rheum Dis 69, 1077-85 (2010).
27. Gharavi, A. G. et al. Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat Genet 43, 321-7 (2011).
28. Yang, C. et al. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers. Immunogenetics 64, 747-53 (2012).
29. Gharavi, A. G. et al. Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy. J Am Soc Nephrol 19, 1008-14 (2008).
30. Kong, X. et al. Evaluation of the Chronic Kidney Disease Epidemiology Collaboration equation for estimating glomerular filtration rate in the Chinese population. Nephrol Dial Transplant 28, 641-51 (2013).
31. Ma, Y. C. et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17, 2937-44 (2006).