Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese

Nephrology Dialysis Transplantation

Volumn 26, Issue 8, 2011, Pages 2544-2549

  Cheng, Wenrong ^a,b   Zhou, Xujie ^a,b   Zhu, Li ^a,b   Shi, Sufang ^a,b   Lv, Jicheng ^a,b   Liu, Lijun ^a,b   Zhang, Hong ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b BEIJING HOSPITAL   (China)

Author keywords

IgA nephropathy; MYH9; polymorphism

Indexed keywords

ADULT; ARTICLE; CHINESE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY BIOPSY; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MYH9 GENE; PATHOGENESIS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; GENOTYPE; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS, IGA; HUMANS; MALE; MOLECULAR MOTOR PROTEINS; MYOSIN HEAVY CHAINS; NEOPLASM GRADING; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS;

EID: 79961088450     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfq768     Document Type: Article

References (28)

1. Barratt J, Feehally J. IgA nephropathy. J Am Soc Nephrol 2005;16:2088-2097 (Pubitemid 41716440)
2. Donadio JV, Grande JP. IgA nephropathy. N Engl J Med 2002;347:738-748 (Pubitemid 35203906)
3. Izzi C, Sanna-Cherchi S, Prati E et al. Familial aggregation of primary glomerulonephritis in an Italian population isolate: Valtrompia study. Kidney Int 2006;69:1033-1040 (Pubitemid 43372178)
4. Scolari F. Inherited forms of IgA nephropathy. J Nephrol 2003;16:317-320 (Pubitemid 37304093)
5. Asanuma K, Mundel P. The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 2003;7:255-259 (Pubitemid 38031285)
6. Sellers JR. Myosins: a diverse superfamily. Biochim Biophys Acta 2000;1496:3-22 (Pubitemid 30155594)
7. Ghiggeri GM, Caridi G, Magrini U et al. Genetics, clinical and pathological features of glomerulonephritis associated with mutations of nonmuscle myosin IIA (Fechtner syndrome). Am J Kidney Dis 2003;41:95-104 (Pubitemid 36043356)
8. Althaus K, Greinacher A. MYH9-related platelet disorders. Semin Thromb Hemost 2009;35:189-203
9. Behar DM, Rosset S, Tzur S et al. African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans. Hum Mol Genet 2010;19:1816-1827
10. Pattaro C, Aulchenko YS, Isaacs A et al. Genome-wide linkage analysis of serum creatinine in three isolated European populations. Kidney Int 2009;76:297-306
11. Kopp JB, Smith MW, Nelson GW et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet 2008;40:1175-1184
12. Kao W, Klag MJ, Meoni LA et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 2008;40:1185-1192
13. Ma YC, Zuo L, Chen JH et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 2006;17:2937-2944 (Pubitemid 44484685)
14. Nelson GW, Freedman BI, Bowden DW et al. Dense mapping of MYH9 localizes the strongest kidney disease associations to the region of introns 13 to 15. Hum Mol Genet 2010;19:1805-1815
15. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215
16. Freedman BI, Hicks PJ, Bostrom MA et al. Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans. Kidney Int 2009;75:736-745
17. Bisceglia L, Cerullo G, Forabosco P et al. Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci. Am J Hum Genet 2006;79:1130-1134 (Pubitemid 44853485)
18. Gharavi AG, Yan Y, Scolari F et al. IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genet 2000;26:354-357
19. Paterson AD, Liu XQ, Wang K et al. Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36. J Am Soc Nephrol 2007;18:2408-2415 (Pubitemid 47203857)
20. Freedman BI, Kopp JB, Winkler CA et al. Polymorphisms in the nonmuscle Myosin Heavy Chain 9 gene (MYH9) are associated with albuminuria in hypertensive African Americans: The HyperGEN Study. Am J Nephrol 2009;29:626-632
21. Dong F, Li SF, Pujol-Moix N et al. Genotype-phenotype correlation in MYH9-related thrombocytopenia. Br J Haematol 2005;130:620-627 (Pubitemid 43899767)
22. Marini M, Bruschi M, Pecci A et al. Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease. Int J Mol Med 2006;17:729-736
23. Singh N, Nainani N, Arora P et al. CKD in MYH9-related disorders. Am J Kidney Dis 2009;54:732-740
24. Genovese G, Friedman DJ, Ross MD et al. Association of Trypanolytic ApoL1 variants with kidney disease in African Americans. Science 2010;329:841-845
25. Tzur S, Rosset S, Shemer R et al. Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene. Hum Genet 2010;128:345-350
26. Genovese G, Tonna SJ, Knob AU et al. A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int 2010;78:698-704
27. Freedman BI, Kopp JB, Langefeld CD et al. The Apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J am Soc Nephrol 2010;21:1422-146
28. Arii J, Goto H, Suenaga T et al. Non-muscle myosin IIAis a functional entry receptor for herpes simplex virus-1. Nature 2010;467:859-862