FCGR2B and FCRLB Gene Polymorphisms Associated with IgA Nephropathy

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Zhou, Xu jie ^a   Cheng, Fa juan ^a   Qi, Yuan yuan ^a   Zhao, Yan feng ^a   Hou, Ping ^a   Zhu, Li ^a   Lv, Ji cheng ^a   Zhang, Hong ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; DNA;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DNA DETERMINATION; FCGR2B GENE; FCRLB GENE; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENOTYPE; GLOMERULUS FILTRATION RATE; HEMATURIA; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; MAJOR CLINICAL STUDY; MALE; PROTEINURIA; QUANTITATIVE TRAIT LOCUS; RECEPTOR GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

GENE DOSAGE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GLOMERULONEPHRITIS, IGA; GPI-LINKED PROTEINS; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RECEPTORS, FC; RECEPTORS, IGG; SEVERITY OF ILLNESS INDEX;

EID: 84876075284     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061208     Document Type: Article

References (42)

1. Berger J, Hinglais N, (1968) [Intercapillary deposits of IgA-IgG]. J Urol Nephrol (Paris) 74: 694-695.
2. Suzuki H, Kiryluk K, Novak J, Moldoveanu Z, Herr AB, et al. (2011) The pathophysiology of IgA nephropathy. J Am Soc Nephrol 22: 1795-1803.
3. Suzuki H, Fan R, Zhang Z, Brown R, Hall S, et al. (2009) Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest 119: 1668-1677.
4. Tissandie E, Morelle W, Berthelot L, Vrtovsnik F, Daugas E, et al. (2011) Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89-IgA and IgG-IgA complexes: common mechanisms for distinct diseases. Kidney Int 80: 1352-1363.
5. Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, et al. (1999) Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104: 73-81.
6. Novak J, Tomana M, Matousovic K, Brown R, Hall S, et al. (2005) IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. Kidney Int 67: 504-513.
7. Novak J, Vu HL, Novak L, Julian BA, Mestecky J, et al. (2002) Interactions of human mesangial cells with IgA and IgA-containing immune complexes. Kidney Int 62: 465-475.
8. Novak J, Raskova KL, Suzuki H, Tomana M, Matousovic K, et al. (2011) IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells. Nephrol Dial Transplant 26: 3451-3457.
9. Mayadas TN, Tsokos GC, Tsuboi N, (2009) Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation 120: 2012-2024.
10. Jancar S, Sanchez CM, (2005) Immune complex-mediated tissue injury: a multistep paradigm. Trends Immunol 26: 48-55.
11. Hashimoto A, Suzuki Y, Suzuki H, Ohsawa I, Brown R, et al. (2012) Determination of severity of murine IgA nephropathy by glomerular complement activation by aberrantly glycosylated IgA and immune complexes. Am J Pathol 181: 1338-1347.
12. Oortwijn BD, Eijgenraam JW, Rastaldi MP, Roos A, Daha MR, et al. (2008) The role of secretory IgA and complement in IgA nephropathy. Semin Nephrol 28: 58-65.
13. Roos A, Rastaldi MP, Calvaresi N, Oortwijn BD, Schlagwein N, et al. (2006) Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J Am Soc Nephrol 17: 1724-1734.
14. Kim SJ, Koo HM, Lim BJ, Oh HJ, Yoo DE, et al. (2012) Decreased circulating C3 levels and mesangial C3 deposition predict renal outcome in patients with IgA nephropathy. PLoS One 7: e40495.
15. Kiryluk K, Novak J, Gharavi AG (2012) Pathogenesis of Immunoglobulin A Nephropathy: Recent Insight from Genetic Studies. Annu Rev Med.
16. Xu G, He Q, Shou Z, Wang H, Zhang X, et al. (2007) NA1/NA2 heterozygote of Fcgr3b is a risk factor for progression of IgA nephropathy in Chinese. J Clin Lab Anal 21: 298-302.
17. Tanaka Y, Suzuki Y, Tsuge T, Kanamaru Y, Horikoshi S, et al. (2005) FcgammaRIIa-131R allele and FcgammaRIIIa-176V/V genotype are risk factors for progression of IgA nephropathy. Nephrol Dial Transplant 20: 2439-2445.
18. Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, et al. (2011) Genome-wide association study identifies susceptibility loci for IgA nephropathy. Nat Genet 43: 321-327.
19. Stranger BE, Montgomery SB, Dimas AS, Parts L, Stegle O, et al. (2012) Patterns of cis regulatory variation in diverse human populations. PLoS Genet 8: e1002639.
20. Niederer HA, Willcocks LC, Rayner TF, Yang W, Lau YL, et al. (2010) Copy number, linkage disequilibrium and disease association in the FCGR locus. Hum Mol Genet 19: 3282-3294.
21. Hollox EJ, Detering JC, Dehnugara T, (2009) An integrated approach for measuring copy number variation at the FCGR3 (CD16) locus. Hum Mutat 30: 477-484.
22. Breunis WB, van Mirre E, Geissler J, Laddach N, Wolbink G, et al. (2009) Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. Hum Mutat 30: E640-E650.
23. Zhou XJ, Lv JC, Bu DF, Yu L, Yang YR, et al. (2010) Copy number variation of FCGR3A rather than FCGR3B and FCGR2B is associated with susceptibility to anti-GBM disease. Int Immunol 22: 45-51.
24. Zhou XJ, Lv JC, Qin LX, Yang HZ, Yu F, et al. (2011) Is FCGR2A a susceptibility gene to systemic lupus erythematosus in Chinese? Lupus 20: 1198-1202.
25. McKinney C, Merriman TR, (2012) Meta-analysis confirms a role for deletion in FCGR3B in autoimmune phenotypes. Hum Mol Genet 21: 2370-2376.
26. Ma YC, Zuo L, Chen JH, Luo Q, Yu XQ, et al. (2006) Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 17: 2937-2944.
27. Lv J, Zhang H, Zhou Y, Li G, Zou W, et al. (2008) Natural history of immunoglobulin A nephropathy and predictive factors of prognosis: a long-term follow up of 204 cases in China. Nephrology (Carlton) 13: 242-246.
28. Nimmerjahn F, Ravetch JV, (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8: 34-47.
29. Espeli M, Clatworthy MR, Bokers S, Lawlor KE, Cutler AJ, et al. (2012) Analysis of a wild mouse promoter variant reveals a novel role for FcgammaRIIb in the control of the germinal center and autoimmunity. J Exp Med 209: 2307-2319.
30. Nimmerjahn F, Ravetch JV, (2011) FcgammaRs in health and disease. Curr Top Microbiol Immunol 350: 105-125.
31. Willcocks LC, Carr EJ, Niederer HA, Rayner TF, Williams TN, et al. (2010) A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. Proc Natl Acad Sci U S A 107: 7881-7885.
32. Smith KG, Clatworthy MR, (2010) FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol 10: 328-343.
33. Ehrhardt GR, Cooper MD, (2011) Immunoregulatory roles for fc receptor-like molecules. Curr Top Microbiol Immunol 350: 89-104.
34. Davis RS, (2007) Fc receptor-like molecules. Annu Rev Immunol 25: 525-560.
35. Santiago T, Kulemzin SV, Reshetnikova ES, Chikaev NA, Volkova OY, et al. (2011) FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA. Int Immunol 23: 43-53.
36. Masuda K, Mori H, Ohara O, Nakayama M, Wang JY, et al. (2010) Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory FcgammaRIIb. Cell Immunol 266: 24-31.
37. Thabet MM, Wesoly J, Slagboom PE, Toes RE, Huizinga TW, (2007) FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians. Ann Rheum Dis 66: 803-806.
38. Zeng Z, Duan Z, Zhang T, Wang S, Li G, et al. (2012) Association of FCRL4 polymorphisms on disease susceptibility and severity of ankylosing spondylitis in Chinese Han population. Clin Rheumatol 31: 1449-1454.
39. Plagnol V, Howson JM, Smyth DJ, Walker N, Hafler JP, et al. (2011) Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet 7: e1002216.
40. Chu X, Pan CM, Zhao SX, Liang J, Gao GQ, et al. (2011) A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet 43: 897-901.
41. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, et al. (2012) A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Arthritis Rheum 64: 2451-2459.
42. Hu XP, Wu JQ, Zhu LP, Wang X, Xu B, et al. (2012) Association of Fcgamma receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients. PLoS One 7: e42439.