Inhaled cationic amphiphilic drug-induced pulmonary phospholipidosis in rats and dogs: Time-course and dose-response of biomarkers of exposure and effect

Toxicology

Volumn 207, Issue 1, 2005, Pages 59-72

  Pauluhn, Jürgen ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Alveolar macrophages; Dosimetry; Lung overloading; Nose only exposure; Pharmacokinetics; Tissue binding

Indexed keywords

AMPHOPHILE; BIOLOGICAL MARKER; BIS[4 (GUANIDINOBENZYLAMINOCARBONYL) 1 PIPERAZINE CARBOXYLATE]; BIS[4 (GUANIDINOBENZYLAMINOCARBONYL) 1 PIPERAZINE CARBOXYLATE]SULFATE; PIPERAZINE DERIVATIVE; SURFACTANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DISEASE PREDISPOSITION; DOG; DOSIMETRY; DRUG BLOOD LEVEL; FEMALE; GASTROINTESTINAL TRACT; LIPIDOSIS; LUNG ALVEOLUS MACROPHAGE; LUNG DISEASE; LUNG LAVAGE; LUNG MINUTE VOLUME; LUNG PARENCHYMA; MALE; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SERUM; SOLUBILITY;

ADMINISTRATION, INHALATION; ANIMALS; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CATIONS, DIVALENT; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LIPIDOSES; LUNG; LUNG DISEASES; MALE; ORGAN SIZE; PHOSPHOLIPIDS; RATS; RATS, WISTAR; SOLUBILITY; SURFACE-ACTIVE AGENTS;

CANIS FAMILIARIS; RATTUS NORVEGICUS;

EID: 10044273873     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.08.012     Document Type: Article

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