Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes

FASEB Journal

Volumn 28, Issue 4, 2014, Pages 1610-1620

  Roosjen, Mark ^a,b   McColl, Bradley ^b   Kao, Betty ^b,c   Gearing, Linden J ^d   Blewitt, Marnie E ^d   Vadolas, Jim ^b,c  

^a VAN HALL LARENSTEIN UNIVERSITY OF APPLIED SCIENCES   (Netherlands)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Epigenetic repressor; Molecular mechanism; RNA interference; hemoglobinopathies

Indexed keywords

B CELL LYMPHOMA LEUKEMIA 11A PROTEIN; DNA METHYLTRANSFERASE 1; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN EPSILON CHAIN; HEMOGLOBIN GAMMA CHAIN; PROTEIN MYB; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; GLOBIN GENE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION REGULATION;

EPIGENETIC REPRESSOR; MOLECULAR MECHANISM; RNA INTERFERENCE; Β-HEMOGLOBINOPATHIES;

ANIMALS; BETA-GLOBINS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; EPSILON-GLOBINS; ERYTHROPOIESIS; FETAL HEMOGLOBIN; GAMMA-GLOBINS; GREEN FLUORESCENT PROTEINS; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; LUMINESCENT PROTEINS; MICE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSGENES;

EID: 84901024768     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.13-242669     Document Type: Article

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