Intravenous sodium nitrite in acute ST-elevation myocardial infarction: A randomized controlled trial (NIAMI)

European Heart Journal

Volumn 35, Issue 19, 2014, Pages

  Siddiqi, Nishat ^a   Neil, Christopher ^a   Bruce, Margaret ^a   MacLennan, Graeme ^a   Cotton, Seonaidh ^a   Papadopoulou, Sofia ^b   Feelisch, Martin ^c   Bunce, Nicholas ^d   Lim, Pitt O ^d   Hildick Smith, David ^e   Horowitz, John ^f   Madhani, Melanie ^g   Boon, Nicholas ^h   Dawson, Dana ^a   Kaski, Juan Carlos ^b   Frenneaux, Michael ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e UK   (United Kingdom)

^f QUEEN ELIZABETH HOSPITAL   (Australia)

^g UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Acute myocardial infarction; Cardioprotection; Ischaemia reperfusion injury; Nitrite

Indexed keywords

CREATINE KINASE; GADOLINIUM; METHEMOGLOBIN; NITRITE; SODIUM NITRITE; TROPONIN I; BIOLOGICAL MARKER; CARDIOTONIC AGENT;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CREATINE KINASE BLOOD LEVEL; DIABETES MELLITUS; FEMALE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE VOLUME; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION; SIDE EFFECT; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HEART MUSCLE REPERFUSION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PERCUTANEOUS CORONARY INTERVENTION; PROCEDURES; TREATMENT OUTCOME;

BIOLOGICAL MARKERS; CARDIOTONIC AGENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; PERCUTANEOUS CORONARY INTERVENTION; SODIUM NITRITE; TREATMENT OUTCOME;

EID: 84900872637     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu096     Document Type: Article

References (40)

1. Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res 2004;61:372-385.
2. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986;74:1124-1136.
3. Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: underlying mechanisms and clinical application. Atherosclerosis 2009;204:334-341.
4. KharbandaRK,MortensenUM,White PA, Kristiansen SB, SchmidtMR,Hoschtitzky JA, Vogel M, Sorensen K, Redington AN, MacAllister R. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 2002;106:2881-2883.
5. Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, Andre-Fouet X, Revel D, Kirkorian G, Monassier JP, Derumeaux G, Ovize M. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008;359:473-481.
6. Lonborg J, Vejlstrup N, Kelbaek H, Botker HE, Kim WY, Mathiasen AB, Jorgensen E, Helqvist S, Saunamaki K, Clemmensen P, Holmvang L, Thuesen L, Krusell LR, Jensen JS, KoberL,TreimanM,Holst JJ,EngstromT.Exenatide reduces reperfusion injury inpatients with ST-segment elevation myocardial infarction. Eur Heart J 33:1491-1499.
7. Botker HE, Kharbanda R, Schmidt MR, Bottcher M, Kaltoft AK,Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Nielsen TT. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375:727-734.
8. Staat P, Rioufol G, Piot C, Cottin Y, Cung TT, L'Huillier I, Aupetit JF, Bonnefoy E, Finet G, Andre-Fouet X, Ovize M. Postconditioning the human heart. Circulation 2005;112:2143-2148.
9. Ludman AJ, Yellon DM, Hausenloy DJ. Cardiac preconditioning for ischaemia: lost in translation. Dis Model Mech 3:35-38.
10. Najjar SS, Rao SV, Melloni C, Raman SV, Povsic TJ, Melton L, BarsnessGW, Prather K, Heitner JF, Kilaru R, Gruberg L, Hasselblad V, Greenbaum AB, Patel M, Kim RJ, Talan M, Ferrucci L, Longo DL, Lakatta EG, Harrington RA. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA 305:1863-1872.
11. Hahn JY, Song YB, Kim EK, Yu CW, Bae JW, Chung WY, Choi SH, Choi JH, Bae JH, An KJ, Park JS, Oh JH, KimSW, Hwang JY, Ryu JK, Park HS, Lim DS, Gwon HC. Ischemic postconditioning during primary percutaneous coronary intervention: the POST Randomized Trial. Circulation 2013;0:1889-1896.
12. Shiva S, Wang X, Ringwood LA, Xu X, Yuditskaya S, Annavajjhala V, Miyajima H, Hogg N, Harris ZL, GladwinMT. Ceruloplasmin is aNOoxidase and nitrite synthase that determines endocrine NO homeostasis. Nat Chem Biol 2006;2:486-493.
13. Lundberg JO,Weitzberg E, Cole JA, Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol 2004;2:593-602.
14. Lundberg JO, GladwinMT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol 2009;5:865-869.
15. Maher AR, Milsom AB, Gunaruwan P, Abozguia K, Ahmed I,Weaver RA, Thomas P, Ashrafian H, Born GV, James PE, Frenneaux MP. Hypoxic modulation of exogenous nitrite-induced vasodilation in humans. Circulation 2008;117:670-677.
16. Srihirun S, Sriwantana T, Unchern S, Kittikool D, Noulsri E, Pattanapanyasat K, Fucharoen S, Piknova B, Schechter AN, Sibmooh N. Platelet inhibition by nitrite is dependent on erythrocytes and deoxygenation. PLoS One 2012;7:e30380.
17. Dejam A, Hunter CJ, Tremonti C, Pluta RM, Hon YY, Grimes G, Partovi K, Pelletier MM, Oldfield EH, Cannon RO III, Schechter AN, Gladwin MT. Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation 2007;116:1821-1831.
18. Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM. Dietary nitrate supplementation reduces theO2 cost of lowintensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 2009;107:1144-1155.
19. Dezfulian C, Shiva S, Alekseyenko A, Pendyal A, Beiser DG, Munasinghe JP, Anderson SA, Chesley CF, Vanden Hoek TL, Gladwin MT. Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I. Circulation 2009;120:897-905.
20. Gonzalez FM, Shiva S, Vincent PS, Ringwood LA, Hsu LY, Hon YY, Aletras AH, CannonRO3rd, GladwinMT, Arai AE. Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation 2008;117:2986-2994.
21. Hendgen-Cotta UB, Merx MW, Shiva S, Schmitz J, Becher S, Klare JP, Steinhoff HJ, Goedecke A, Schrader J, Gladwin MT, Kelm M, Rassaf T. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemiareperfusion injury. Proc Natl Acad Sci USA 2008;105:10256-10261.
22. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF,Wang X, Kevil CG, Gladwin MT, Lefer DJ. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest 2005;115: 1232-1240.
23. Siddiqi N, Bruce M, Neil CJ, Jagpal B, Maclennon G, Cotton SC, Papadopoulo SA, Bunce N, Lim P, Schwarz K, Singh S, Hildick-Smith D, Horowitz JD, Madhani M, Boon N, Kaski JC, Dawson D, Frenneaux MP. Protocol: does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI). J Transl Med 11:116.
24. Kramer CM, Barkhausen J, Flamm SD, Kim RJ, Nagel E, Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized P. Standardized cardiovascular magnetic resonance(CMR) protocols 2013 update. J Cardiovasc Magn Reson 2013;15:91.
25. Flett AS,Hasleton J,Cook C,Hausenloy D,Quarta G, AritiC,MuthuranguV,Moon JC. Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance. JACC Cardiovasc Imaging 2011;4:150-156.
26. O'Regan DP, Ahmed R, Neuwirth C, Tan Y, Durighel G, Hajnal JV, Nadra I, Corbett SJ, Cook SA. Cardiac MRI of myocardial salvage at the peri-infarct border zones after primary coronary intervention. Am J Physiol Heart Circ Physiol 2009;297: H340-H346.
27. Eitel I, Desch S, Fuernau G, Hildebrand L, Gutberlet M, Schuler G, Thiele H. Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J Am Coll Cardiol 55: 2470-2479.
28. White IR, Horton NJ,Carpenter J, Pocock SJ. Strategy for intentionto treat analysis in randomised trials with missing outcome data. BMJ 2011;342:d40.
29. White IR, Kalaitzaki E, Thompson SG. Allowing for missing outcome data and incomplete uptake of randomised interventions, with application to an Internet-based alcohol trial. Stat Med 2011;30:3192-3207.
30. Feelisch M, Fernandez BO, Bryan NS, Garcia-Saura MF, Bauer S, Whitlock DR, Ford PC, Janero DR, Rodriguez J, Ashrafian H. Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and-scavenging systems. J Biol Chem 2008;283:33927-33934.
31. Murillo D, Kamga C, Mo L, Shiva S. Nitrite as a mediator of ischemic preconditioning and cytoprotection. Nitric Oxide 2011;25:70-80.
32. Doganci S, Yildirim V, Bolcal C, Korkusuz P, Gumusel B, Demirkilic U, Aydin A. Sodium nitrite and cardioprotective effect in pig regional myocardial ischemia-reperfusion injury model. Adv Clin Exp Med 2012;21:713-726.
33. Jones DA, Andiapen M, Van-Eijl TJ,Webb AJ, Antoniou S, Schilling RJ, Ahluwalia A, Mathur A. The safety and efficacy of intracoronary nitrite infusion during acute myocardial infarction (NITRITE-AMI): study protocol of a randomised controlled trial. BMJ Open 2013;3.
34. Tsang A, Hausenloy DJ, Mocanu MM, Carr RD, Yellon DM. Preconditioning the diabetic heart: the importance of Akt phosphorylation. Diabetes 2005;54:2360-2364.
35. Yui H, Imaizumi U, Beppu H, Ito M, Furuya M, Arisaka H, Yoshida K. Comparative effects of verapamil, nicardipine, and nitroglycerin on myocardial ischemia/reperfusion injury. Anesthesiol Res Pract 2011;2011:521084.
36. Calvert JW, Lefer DJ. Myocardial protection by nitrite. Cardiovasc Res 2009;83: 195-203.
37. Bolli R, Becker L, Gross G, Mentzer R Jr, Balshaw D, LathropDA. Myocardial protection at a crossroads: the need for translation into clinical therapy. Circ Res 2004;95: 125-134.
38. Janero DR, Bryan NS, Saijo F, Dhawan V, Schwalb DJ,Warren MC, Feelisch M. Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo. Proc Natl Acad Sci USA 2004;101:16958-16963.
39. Jung KH, Chu K, Ko SY, Lee ST, Sinn DI, Park DK, Kim JM, Song EC, Kim M, Roh JK. Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia-reperfusion injury. Stroke 2006;37:2744-2750.
40. Gori T, Daiber A, Di Stolfo G, Sicuro S, Dragoni S, Lisi M, Munzel T, Forconi S, Parker JD. Nitroglycerine causes mitochondrial reactive oxygen species production: in vitro mechanistic insights. Can J Cardiol 2007;23:990-992.