Protocol: Does sodium nitrite administration reduce ischaemia-reperfusion injury in patients presenting with acute ST segment elevation myocardial infarction? Nitrites in acute myocardial infarction (NIAMI)

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Siddiqi, Nishat ^a   Bruce, Margaret ^a   Neil, Christopher J ^a   Jagpal, Baljit ^a   Maclennon, Graeme ^b   Cotton, Seonaidh C ^b   Papadopoulo, Sofia A ^c   Bunce, Nicholas ^d   Lim, Pitt ^d   Schwarz, Konstantin ^a   Singh, Satnam ^a   Hildick Smith, David ^e   Horowitz, John D ^f   Madhani, Melanie ^g   Boon, Nicholas ^h   Kaski, Juan Carlos ^c   Dawson, Dana ^a   Frenneaux, Michael P ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

^c Division of Cardiac and Vascular Sciences   (United Kingdom)

^d ST GEORGE'S UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e Brighton and Sussex University Hospitals   (United Kingdom)

^f QUEEN ELIZABETH HOSPITAL   (Australia)

^g UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cardioprotection; Ischaemia reperfusion injury; Myocardial infarction; Primary percutaneous coronary intervention; Sodium nitrite

Indexed keywords

CREATINE KINASE; PLACEBO; SODIUM NITRITE; TROPONIN I;

ADULT; AREA AT RISK; ARTICLE; CARDIOVASCULAR MAGNETIC RESONANCE; CARDIOVASCULAR PARAMETERS; ENZYME BLOOD LEVEL; FEMALE; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HUMAN; MALE; MULTICENTER STUDY (TOPIC); PERCUTANEOUS CORONARY INTERVENTION; PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REPERFUSION INJURY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

ADOLESCENT; ADULT; AGED; CARDIOTONIC AGENTS; DOUBLE-BLIND METHOD; FEMALE; GREAT BRITAIN; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NITRIC OXIDE; PERCUTANEOUS CORONARY INTERVENTION; REPERFUSION INJURY; SODIUM NITRITE; YOUNG ADULT;

EID: 84877011046     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-116     Document Type: Article

References (34)

1. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 2003, 361(9351):13-20. 10.1016/S0140-6736(03)12113-7, 12517460.
2. Krumholz HM. Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J 2000, 139(1 Pt 1):72-77.
3. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007, 357(11):1121-1135. 10.1056/NEJMra071667, 17855673.
4. Halestrap AP, Clarke SJ, Javadov SA. Mitochondrial permeability transition pore opening during myocardial reperfusion-a target for cardioprotection. Cardiovasc Res 2004, 61(3):372-385. 10.1016/S0008-6363(03)00533-9, 14962470.
5. Halestrap AP. Mitochondria and reperfusion injury of the heart-a holey death but not beyond salvation. J Bioenerg Biomembr 2009, 41(2):113-121. 10.1007/s10863-009-9206-x, 19357938.
6. Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 1986, 74(5):1124-1136. 10.1161/01.CIR.74.5.1124, 3769170.
7. Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: united at reperfusion. Pharmacol Ther 2007, 116(2):173-191. 10.1016/j.pharmthera.2007.06.005, 17681609.
8. Sumeray MS, Yellon DM. Myocardial preconditioning. What have we learned?. Eur Heart J 1997, 18 Suppl A:p. A8-p. A14.
9. Yellon DM, Downey JM. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev 2003, 83(4):1113-1151.
10. Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: underlying mechanisms and clinical application. Atherosclerosis 2009, 204(2):334-341. 10.1016/j.atherosclerosis.2008.10.029, 19081095.
11. Kharbanda RK. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 2002, 106(23):2881-2883. 10.1161/01.CIR.0000043806.51912.9B, 12460865.
12. Tsang A. Preconditioning the diabetic heart: the importance of Akt phosphorylation. Diabetes 2005, 54(8):2360-2364. 10.2337/diabetes.54.8.2360, 16046302.
13. Miura T, Miki T. Limitation of myocardial infarct size in the clinical setting: current status and challenges in translating animal experiments into clinical therapy. Basic Res Cardiol 2008, 103(6):501-513. 10.1007/s00395-008-0743-y, 18716709.
14. Botker HE. Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 2010, 375(9716):727-734. 10.1016/S0140-6736(09)62001-8, 20189026.
15. Hackett D. Intermittent coronary occlusion in acute myocardial infarction. Value of combined thrombolytic and vasodilator therapy. N Engl J Med 1987, 317(17):1055-1059. 10.1056/NEJM198710223171704, 3657868.
16. Piot C. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008, 359(5):473-481. 10.1056/NEJMoa071142, 18669426.
17. Lundberg JO. Nitrate, bacteria and human health. Nat Rev Microbiol 2004, 2(7):593-602. 10.1038/nrmicro929, 15197394.
18. Furchgott RF. Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide. Biosci Rep 1999, 19(4):235-251. 10.1023/A:1020537506008, 10589989.
19. Kollau A. Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin. Nitric Oxide 2009, 20(1):53-60. 10.1016/j.niox.2008.09.003, 18951990.
20. Basu S. Nitrite reductase activity of cytochrome c. J Biol Chem 2008, 283(47):32590-32597. 10.1074/jbc.M806934200, 2583304, 18820338.
21. Gladwin MT, Kim-Shapiro DB. The functional nitrite reductase activity of the heme-globins. Blood 2008, 112(7):2636-2647. 10.1182/blood-2008-01-115261, 2556603, 18596228.
22. Webb AJ. Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res 2008, 103(9):957-964. 10.1161/CIRCRESAHA.108.175810, 2841343, 18818408.
23. Maher AR. Hypoxic modulation of exogenous nitrite-induced vasodilation in humans. Circulation 2008, 117(5):670-677. 10.1161/CIRCULATIONAHA.107.719591, 18212289.
24. Calvert JW, Lefer DJ. Myocardial protection by nitrite. Cardiovasc Res 2009, 83(2):195-203. 10.1093/cvr/cvp079, 2701719, 19251721.
25. Hendgen-Cotta UB. Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA 2008, 105(29):10256-10261. 10.1073/pnas.0801336105, 2481313, 18632562.
26. Webb A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci USA 2004, 101(37):13683-13688. 10.1073/pnas.0402927101, 518813, 15347817.
27. Dezfulian C. Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I. Circulation 2009, 120(10):897-905. 10.1161/CIRCULATIONAHA.109.853267, 2755623, 19704094.
28. Gonzalez FM. Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation 2008, 117(23):2986-2994. 10.1161/CIRCULATIONAHA.107.748814, 2587279, 18519850.
29. Baskin SI, Horowitz AM, Nealley EW. The antidotal action of sodium nitrite and sodium thiosulfate against cyanide poisoning. J Clin Pharmacol 1992, 32(4):368-375. 10.1002/j.1552-4604.1992.tb03849.x, 1569239.
30. Yawata Y. New variant of cytochrome b5 reductase deficiency (b5RKurashiki) in red cells, platelets, lymphocytes, and cultured fibroblasts with congenital methemoglobinemia, mental and neurological retardation, and skeletal anomalies. Am J Hematol 1992, 40(4):299-305. 10.1002/ajh.2830400411, 1503085.
31. Rehman HU. Methemoglobinemia. West J Med 2001, 175(3):193-196. 10.1136/ewjm.175.3.193, 1071541, 11527852.
32. Dezfulian C. Nitrite therapy is neuroprotective and safe in cardiac arrest survivors. Nitric Oxide 2012, 26(4):241-250. 10.1016/j.niox.2012.03.007, 22484664.
33. O'Regan DP. Cardiac MRI of myocardial salvage at the peri-infarct border zones after primary coronary intervention. Am J Physiol Heart Circ Physiol 2009, 297(1):H340-H346. 10.1152/ajpheart.00011.2009, 2711719, 19429834.
34. Schulz-Menger J. Cardiovascular magnetic resonance of acute myocardial infarction at a very early stage. J Am Coll Cardiol 2003, 42(3):513-518. 10.1016/S0735-1097(03)00717-4, 12906982.