Predisposition - Obesity phenotype;Prädisposition - Phänotyp der Adipositas

Deutsche Medizinische Wochenschrift

Volumn 139, Issue 21, 2014, Pages 1116-1120

  Bluher M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

adipose tissue; fat distribution; insulin resistance; metabolically healthy obesity; obesity; type 2 diabetes

Indexed keywords

ADIPOSE TISSUE; CARDIOMETABOLIC RISK; DISEASE PREDISPOSITION; FAT CONTENT; FAT MASS; HIGH RISK PATIENT; HUMAN; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; REVIEW; RISK ASSESSMENT; VASCULAR DISEASE;

ADULT; AGED; BLOOD GLUCOSE; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HEALTH BEHAVIOR; HUMANS; INSULIN RESISTANCE; LIFE STYLE; MIDDLE AGED; OBESITY; PHENOTYPE; PREDIABETIC STATE; PROGNOSIS; RISK FACTORS;

EID: 84900855889     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0034-1369942     Document Type: Review

References (40)

1. Achenbach P., Bonifacio E., Koczwara K. et al. Natural history of type 1 diabetes. Diabetes: 2005; 4 25 S31
2. Adams K. F., Schatzkin A., Harris T. B. et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med: 2006; 355 763 778 (Pubitemid 44285582)
3. Arsenault B. J., Cote M., Cartier A. et al. Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure. Atherosclerosis: 2009; 207 530 533
4. Bell L. M., Byrne S., Thompson A. et al. Increasing body mass index z-score is continuously associated with complications of overweight in children, even in the healthy range. J Clin Endocrinol Metab: 2007; 92 517 522
5. Blüher M. Are there still healthy obese patients? Curr Opin Endocrinol Diabetes Obes: 2012; 19 341 346
6. Blüher M. Adipose tissue dysfunction contributes to obesity related metabolic diseases. Best Pract Res Clin Endocrinol Metab: 2013; 27 163 177
7. Bonora E., Kiechl S., Willeit J. et al. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes: 1998; 47 1643 1649 (Pubitemid 28445355)
8. Bouchard C., Tremblay A., Depres J. P. et al. The response to long-term overfeeding in identical twins. N Engl J Med: 1990; 322 1477 1482 (Pubitemid 20179860)
9. Calori G., Lattuada G., Piemonti L. et al. Prevalence, metabolic features and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care: 2011; 34 210 215
10. Carlsson L. M., Peltonen M., Ahlin S. et al. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N Engl J Med: 2012; 367 695 704
11. Dvorak R. V., DeNino W. F., Ades P. A. Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. Diabetes: 1999; 48 2210 2214 (Pubitemid 29521852)
12. Ferrannini E., Natali A., Bell P. et al. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest: 1997; 100 1166 1173
13. Hamer M., Stamatakis E. Metabolically Healthy Obesity and Risk of All-Cause and Cardiovascular Disease Mortality. J Clin Endocrinol Metab: 2012; 97 2482 2488
14. Kantartzis K., Machann J., Schick F. et al. Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia: 2011; 54 864 868
15. Karelis A. D., Messier V., Brochu M. et al. Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia: 2008; 51 1752 1754
16. Klöting N., Fasshauer M., Dietrich A. et al. Insulin sensitive obesity. Am J Physiol Endocrinol Metab: 2010; 299 E506 E515
17. Klöting N., Stumvoll M., Blüher M. The biology of visceral fat. Internist (Berl): 2007; 48 126 133 (Pubitemid 46362126)
18. Kuk J. L., Ardern C. I., Church T. S. et al. Edmonton Obesity Staging System: association with weight history and mortality risk. Appl Physiol Nutr Metab: 2011; 36 570 576
19. Lee D. C., Sui X., Church T. S. et al. Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men. Diabetes Care: 2009; 32 257 262
20. McAuley P. A., Blair S. N. Obesity paradoxes. J Sports Sci: 2011; 29 773 782
21. Meigs J. B., Wilson P. W., Fox C. S. et al. Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab: 2006; 91 2906 2912 (Pubitemid 44271734)
22. Mokdad A. H., Ford E. S., Bowman B. A. et al. Prevalence of obesity, diabetes, and obesity-related health risk factors. JAMA: 2003; 289 76 79 (Pubitemid 36026281)
23. Muscelli E., Camastra S., Gastaldelli A. et al. Influence of duration of obesity on the insulin resistance of obese non-diabetic patients. Int J Obes Relat Metab Disord: 1998; 22 262 267 (Pubitemid 28112027)
24. Padwal R. S., Pajewski N. M., Allison D. B. et al. Using the Edmonton obesity staging system to predict mortality in a population-representative cohort of people with overweight and obesity. CMAJ: 2011; 183 E1059 E1066
25. Perusse L., Depres J. P., Lemieux S. et al. Familial aggregation of abdominal visceral fat: results from the Quebec family study. Metabolism: 1996; 45 378 382 (Pubitemid 26102645)
26. Plomin R., Owen M. J., McGuffin P. The genetic basis of complex human behaviors. Science: 1994; 264 1733 1739 (Pubitemid 24227749)
27. Raggi M. C., Sharma A. M., Jacob S. Edmonoton Obesity Staging Sysstem: Therapiedringlichkeit bei Adipositas abschätzen. Diabetologie, Stoffwechsel und Herz: 2012; 21 321 324
28. Reaven G. M. Importance of identifying the overweight patient who will benefit the most by losing weight. Ann Intern Med: 2003; 138 420 423 (Pubitemid 36262653)
29. Schulze M. B., Hoffmann K., Boeing H. et al. An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes. Diabetes Care: 2007; 30 510 515 (Pubitemid 46354326)
30. Sharma A. M., Kushner R. F. A proposed clinical staging system for obesity. Int J Obes (Lond): 2009; 33 289 295
31. Shin M. J., Hyun Y. J., Kim O. Y. et al. Weight loss effect on inflammation and LDL oxidation in metabolically healthy but obese (MHO) individuals: low inflammation and LDL oxidation in MHO women. Int J Obes (Lond): 2006; 30 1529 1534 (Pubitemid 44470202)
32. Sims E. AH. Are there persons who are obese, but metabolically healthy? Metabolism: 2001; 50 1499 1504 (Pubitemid 34007425)
33. Stefan N., Kantartzis K., Machann J. et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med: 2008; 168 1609 1616
34. Thomas E. L., Parkinson J. R., Frost G. S. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring): 2012; 20 76 87
35. Tuomilehto J., Lindström J., Eriksson J. G. et al. Finnish Diabetes Prevention Study Group Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med: 2001; 344 1343 1350 (Pubitemid 32378388)
36. van Vliet-Ostaptchouk J. V., Nuotio M. L., Slagter S. N. et al. The prevalence of metabolic syndrome and metabolically healthy obesity in Europe. BMC Endocr Disord: 2014; 14 9
37. Voulgari C., Tentolouris N., Dilaveris P. Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol: 2011; 58 1343 1350
38. Wadden T. A. Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials. Ann Intern Med: 1993; 119 688 693 (Pubitemid 23313690)
39. Weinstein A. R., Sesso H. D., Lee I. M. et al. Relationship of physical activity vs body mass index with type 2 diabetes in women. JAMA: 2004; 292 1188 1194 (Pubitemid 39167409)
40. Wildman R. P., Muntner P., Reynolds K. et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med: 2008; 168 1617 1624