Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants

Pediatric Research

Volumn 75, Issue 6, 2014, Pages 781-787

  O'Shea, T Michael ^a   Joseph, Robert M ^b   Kuban, Karl C K ^c   Allred, Elizabeth N ^d   Ware, Janice ^d   Coster, Taryn ^d   Fichorova, Raina N ^e   Dammann, Olaf ^f,g   Leviton, Alan ^d  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON MEDICAL CENTER   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL11 CHEMOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 3; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 4; PROTEIN; RANTES; SERUM AMYLOID A; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; CELL ADHESION MOLECULE; ICAM3 PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; PEROXIDASE; PLASMA PROTEIN; TUMOR NECROSIS FACTOR;

ARTICLE; BEHAVIOR DISORDER; BLOOD ANALYSIS; CHILD; CHILD BEHAVIOR CHECKLIST; DISEASE ASSOCIATION; GESTATIONAL AGE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OBSERVATIONAL STUDY; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RISK FACTOR; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIRTH WEIGHT; BLOOD; CHILD BEHAVIOR; CLINICAL TRIAL; COHORT ANALYSIS; GENETICS; LUMINESCENCE; NEWBORN; ODDS RATIO; PHYSIOLOGY; PRESCHOOL CHILD; UNITED STATES;

ANTIGENS, CD; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; BIRTH WEIGHT; BLOOD PROTEINS; CELL ADHESION MOLECULES; CHILD BEHAVIOR; CHILD, PRESCHOOL; COHORT STUDIES; GESTATIONAL AGE; HUMANS; INFANT, EXTREMELY PREMATURE; INFANT, NEWBORN; INFLAMMATION; INTERLEUKIN-6; INTERLEUKIN-8; LUMINESCENT MEASUREMENTS; ODDS RATIO; PEROXIDASE; TUMOR NECROSIS FACTORS; UNITED STATES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84900853547     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.41     Document Type: Article

References (40)

1. O'Shea TM, Downey LC, Kuban KK. Extreme prematurity and attention defcit: epidemiology and prevention. Front Hum Neurosci 2013;7:578.
2. Kirkhaug B, Drugli MB, Lydersen S, Mørch WT. Associations between high levels of conduct problems and co-occurring problems among the youngest boys and girls in schools: a cross-sectional study. Nord J Psychiatry 2013;67:225-32.
3. Polderman TJ, Boomsma DI, Bartels M, Verhulst FC, Huizink AC. A systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatr Scand 2010;122:271-84.
4. Knapp M, King D, Healey A, Tomas C. Economic outcomes in adulthood and their associations with antisocial conduct, attention defcit and anxiety problems in childhood. J Ment Health Policy Econ 2011;14: 137-47.
5. Reiss F. Socioeconomic inequalities and mental health problems in children and adolescents: a systematic review. Soc Sci Med 2013;90:24-31.
6. Leviton A, Kuban K, O'Shea TM, et al. The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns: the ELGAN study. J Pediatr 2011;158:897-903.e1-5.
7. O'Shea TM, Allred EN, Kuban KC, et al.; Extremely Low Gestational Age Newborn (ELGAN) Study Investigators. Elevated concentrations of infammation-related proteins in postnatal blood predict severe developmental delay at 2 years of age in extremely preterm infants. J Pediatr 2012;160:395-401.e4.
8. Kuban K, O'Shea TM, Allred EN, et al. Systemic infammation and cerebral palsy risk in extremely preterm infants. J Child Neurol 2014; e-pub ahead of print 18 March 2014.
9. Reijneveld SA, de Kleine MJ, van Baar AL, et al. Behavioural and emotional problems in very preterm and very low birthweight infants at age 5 years. Arch Dis Child Fetal Neonatal Ed 2006;91:F423-8.
10. Scott MN, Taylor HG, Fristad MA, et al. Behavior disorders in extremely preterm/extremely low birth weight children in kindergarten. J Dev Behav Pediatr 2012;33:202-13.
11. th post-menstrual week. Early Hum Dev 2011;87: 325-30.
12. Meyer U, Feldon J, Dammann O. Schizophrenia and autism: both shared and disorder-specifc pathogenesis via perinatal infammation? Pediatr Res 2011;69(5 Pt 2):26R-33R.
13. Favrais G, van de Looij Y, Fleiss B, et al. Systemic infammation disrupts the developmental program of white matter. Ann Neurol 2011;70:550-65.
14. Leviton A, Gressens P. Neuronal damage accompanies perinatal white-matter damage. Trends Neurosci 2007;30:473-8.
15. Elia J, Sackett J, Turner T, et al. Attention-defcit/hyperactivity disorder genomics: update for clinicians. Curr Psychiatry Rep 2012;14:579-89.
16. Vuillermot S, Joodmardi E, Perlmann T, Ögren SO, Feldon J, Meyer U. Prenatal immune activation interacts with genetic Nurr1 defciency in the development of attentional impairments. J Neurosci 2012;32:436-51.
17. Miller S P, Cozzio CC, Goldstein RB, et al. Comparing the diagnosis of white matter injury in premature newborns with serial MR imaging and transfontanel ultrasonography fndings. AJNR Am J Neuroradiol 2003;24:1661-9.
18. de la Fuente A, Xia SG, Branch C, Li XB. A review of attention-defcit/ hyperactivity disorder from the perspective of brain networks. Front Hum Neurosci 2013; 7:192.
19. Shang CY, Wu YH, Gau SS, Tseng WY. Disturbed microstructural integrity of the frontostriatal fber pathways and executive dysfunction in children with attention defcit hyperactivity disorder. Psychol Med 2013;43:1093-107.
20. Johnson S, Hollis C, Kochhar P, Hennessy E, Wolke D, Marlow N. Psychiatric disorders in extremely preterm children: longitudinal fnding at age 11 years in the EPICure study. J Am Acad Child Adolesc Psychiatry 2010;49:453-63.e1.
21. th week of gestation: an epidemiologic approach to classifcation. Am J Epidemiol 2008;168:980-9.
22. McElrath TF, Fichorova RN, Allred EN, et al.; ELGAN Study Investigators. Blood protein profles of infants born before 28 weeks difer by pregnancy complication. Am J Obstet Gynecol 2011;204:418.e1-418.e12.
23. Hecht JL, Fichorova RN, Tang VF, Allred EN, McElrath TF, Leviton A; Elgan Study Investigators. Relationship Between Neonatal Blood Protein Concentrations and Placenta Histologic Characteristics in Extremely Low GA Newborns. Pediatr Res 2011;69:68-73.
24. Fichorova RN, Onderdonk AB, Yamamoto H, et al.; Extremely Low Gestation Age Newborns (ELGAN) Study Investigators. Maternal microbe-spe-cifc modulation of infammatory response in extremely low-gestational-age newborns. MBio 2011;2:e00280-10.
25. Leviton A, O'Shea TM, Bednarek FJ, Allred EN, Fichorova RN, Dammann O; ELGAN Study Investigators. Systemic responses of preterm newborns with presumed or documented bacteraemia. Acta Paediatr 2012;101:355-9.
26. Martin CR, Bellomy M, Allred EN, Fichorova RN, Leviton A. Systemic infammation associated with severe intestinal injury in extremely low ges-tational age newborns. Fetal Pediatr Pathol 2013;32:222-34.
27. Bose CL, Laughon MM, Allred EN, et al.; ELGAN Study Investigators. Systemic infammation associated with mechanical ventilation among extremely preterm infants. Cytokine 2013;61:315-22.
28. Beloosesky R, Ginsberg Y, Khatib N, et al. Prophylactic maternal N-acet-ylcysteine in rats prevents maternal infammation-induced ofspring cerebral injury shown on magnetic resonance imaging. Am J Obstet Gynecol 2013;208:213.e1-6.
29. Gitto E, Reiter RJ, Sabatino G, et al. Correlation among cytokines, bron-chopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment. J Pineal Res 2005;39:287-93.
30. Leonard CH, Clyman RI, Piecuch RE, Juster R P, Ballard RA, Behle MB. Efect of medical and social risk factors on outcome of prematurity and very low birth weight. J Pediatr 1990;116:620-6.
31. Tompson RJ Jr, Goldstein RF, Oehler JM, Gustafson KE, Catlett AT, Brazy JE. Developmental outcome of very low birth weight infants as a function of biological risk and psychosocial risk. J Dev Behav Pediatr 1994;15:232-8.
32. Anselmi L, Barros FC, Teodoro ML, et al. Continuity of behavioral and emotional problems from pre-school years to pre-adolescence in a developing country. J Child Psychol Psychiatry 2008;49:499-507.
33. O'Shea TM, Allred EN, Dammann O, et al.; ELGAN study Investigators. The ELGAN study of the brain and related disorders in extremely low ges-tational age newborns. Early Hum Dev 2009;85:719-25.
34. Kuban K, Adler I, Allred EN, et al. Observer variability assessing US scans of the preterm brain: the ELGAN study. Pediatr Radiol 2007;37:1201-8.
35. Fichorova RN, Richardson-Harman N, Alfano M, et al. Biological and technical variables afecting immunoassay recovery of cytokines from human serum and simulated vaginal fuid: a multicenter study. Anal Chem 2008;80:4741-51.
36. Fichorova RN, Trifonova RT, Gilbert RO, et al. Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infect Immun 2006;74: 5773-9.
37. Achenbach TM, Rescorla LA. 2000 Manual for the ASEBA Preschool Forms and Profles. Burlington, Vermont: University of Vermont, Research Center for Children, Youth, and Families, 2000.
38. Bayley N. Bayley Scales of Infant Development-Second Edition. San Antonio, TX: Psychological Corporation, 1993.
39. Roberts G, Anderson PJ, Doyle LW; Victorian Infant Collaborative Study Group. The stability of the diagnosis of developmental disability between ages 2 and 8 in a geographic cohort of very preterm children born in 1997. Arch Dis Child 2010;95:786-90.
40. Sparrow SS, Balla DA, Cicchetti DV. Vineland Adaptive Behavioral Scales. Circle Pines, MN: American Guidance Service, 1984. Stroke Stroke Development