Yohimbine enhancement of exposure therapy for social anxiety disorder: A randomized controlled trial

Biological Psychiatry

Volumn 75, Issue 11, 2014, Pages 840-846

  Smits, Jasper A J ^a   Rosenfield, David ^b   Davis, Michelle L ^a   Julian, Kristin ^b   Handelsman, Pamela R ^b   Otto, Michael W ^c   Tuerk, Peter ^d   Shiekh, Michael ^b   Rosenfield, Ben ^e   Hofmann, Stefan G ^c   Powers, Mark B ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b SOUTHERN METHODIST UNIVERSITY   (United States)

^c BOSTON UNIVERSITY   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e University of Minnesota   (United States)

Author keywords

Cognitive behavioral therapy; cognitive enhancer; exposure therapy; social anxiety disorder; social phobia; yohimbine

Indexed keywords

PLACEBO; YOHIMBINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL GLOBAL IMPRESSION SCALE; DEPRESSION; DEPRESSION INVENTORY; DISEASE SEVERITY; DSM-IV; EXERCISE; FEAR; FEMALE; FOLLOW UP; HUMAN; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; SOCIAL PHOBIA; VIRTUAL REALITY EXPOSURE THERAPY; ANXIETY DISORDERS; BEHAVIOR THERAPY; CONTROLLED STUDY; MULTIMODALITY CANCER THERAPY; REINFORCEMENT; TREATMENT OUTCOME;

ADULT; ANXIETY DISORDERS; COMBINED MODALITY THERAPY; EXTINCTION, PSYCHOLOGICAL; FEAR; FEMALE; HUMANS; IMPLOSIVE THERAPY; MALE; TREATMENT OUTCOME; YOHIMBINE;

EID: 84900834773     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2013.10.008     Document Type: Article

References (48)

1. K.C. Anderson, and T.R. Insel The promise of extinction research for the prevention and treatment of anxiety disorders Biol Psychiatry 60 2006 319 321
2. M. Davis, K. Ressler, B.O. Rothbaum, and R. Richardson Effects of D-cycloserine on extinction: Translation from preclinical to clinical work Biol Psychiatry 60 2006 369 375
3. W.A. Falls, J. Miserendino, and M. Davis Extinction of fear-potentiated startle: Blockade by infusion of an NMDA antagonist into the amygdala J Neurosci 12 1992 854 863
4. D.L. Walker, K.J. Ressler, K.T. Lu, and M. Davis Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats J Neurosci 22 2002 2343 2351
5. K.J. Ressler, B.O. Rothbaum, L. Tannenbaum, P. Anderson, K. Graap, and E. Zimand et al. Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear Arch Gen Psychiatry 61 2004 1136 1144
6. S.G. Hofmann, A.E. Meuret, J.A. Smits, N.M. Simon, M.H. Pollack, and K. Eisenmenger et al. Augmentation of exposure therapy with D-cycloserine for social anxiety disorder Arch Gen Psychiatry 63 2006 298 304
7. S.G. Hofmann, J.A. Smits, D. Rosenfield, N. Simon, M.W. Otto, and A.E. Meuret et al. D-cycloserine as an augmentation strategy with cognitive-behavioral therapy for social anxiety disorder Am J Psychiatry 170 2013 751 758
8. M.M. Norberg, J.H. Krystal, and D.F. Tolin A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy Biol Psychiatry 63 2008 1118 1126
9. J.A. Smits, D. Rosenfield, M.W. Otto, M.B. Powers, S.G. Hofmann, and M.J. Telch et al. D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: Evidence from the treatment of height phobia Biol Psychiatry 73 2013 1054 1058
10. A. Holmes, and G.J. Quirk Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders - the case of yohimbine Trends Pharmacol Sci 31 2010 2 7
11. S.W. Tam, M. Worcel, and M. Wyllie Yohimbine: A clinical review Pharmacol Ther 91 2001 215 243
12. J.L. McGaugh Memory - a century of consolidation Science 287 2000 248 251
13. J.L. McGaugh The amygdala modulates the consolidation of memories of emotionally arousing experiences Annu Rev Neurosci 27 2004 1 28
14. G.B. Kaplan, and K.A. Moore The use of cognitive enhancers in animal models of fear extinction Pharmacol Biochem Behav 99 2011 217 228
15. P.H. Janak, and L.H. Corbit Deepened extinction following compound stimulus presentation: noradrenergic modulation Learn Mem 18 2011 1 10
16. C.K. Cain, A.M. Blouin, and M. Barad Adrenergic transmission facilitates extinction of conditional fear in mice Learn Mem 11 2004 179 187
17. K. Hefner, N. Whittle, J. Juhasz, M. Norcross, R.M. Karlsson, and L.M. Saksida et al. Impaired fear extinction learning and cortico-amygdala circuit abnormalities in a common genetic mouse strain J Neurosci 28 2008 8074 8085
18. R.W. Morris, and M.E. Bouton The effect of yohimbine on the extinction of conditioned fear: a role for context Behav Neurosci 121 2007 501 514
19. D. Mueller, L.A. Olivera-Figueroa, D.S. Pine, and G.J. Quirk The effects of yohimbine and amphetamine on fear expression and extinction in rats Psychopharmacology (Berl) 204 2009 599 606
20. M.B. Powers, J.A. Smits, M.W. Otto, C. Sanders, and P.M. Emmelkamp Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: A randomized placebo controlled trial of yohimbine augmentation J Anxiety Disord 23 2009 350 356
21. K. Meyerbroeker, M.B. Powers, A. van Stegeren, and P.M. Emmelkamp Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial Psychother Psychosom 81 2012 29 37
22. J.A. Smits, D. Rosenfield, M.W. Otto, L. Marques, M.L. Davis, and A.E. Meuret et al. D-cycloserine enhancement of exposure therapy for social anxiety disorder depends on the success of exposure sessions J Psychiatr Res 47 2013 1455 1461
23. A.R. Davis, A.D. Shields, J.L. Brigman, M. Norcross, Z.A. McElligott, A. Holmes, and D.G. Winder Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent process Learn Mem 15 2008 667 676
24. K.L. Price, N.L. Baker, A.L. McRae-Clark, M.E. Saladin, S.M. Desantis, E.J. Santa Ana, and K.T. Brady A randomized, placebo-controlled laboratory study of the effects of D-cycloserine on craving in cocaine-dependent individuals Psychopharmacology (Berl) 226 2013 739 746
25. A.P. Kennedy, R.E. Gross, N. Whitfield, K.P. Drexler, and C.D. Kilts A controlled trial of the adjunct use of D-cycloserine to facilitate cognitive behavioral therapy outcomes in a cocaine-dependent population Addict Behav 37 2012 900 907
26. M. Soeter, and M. Kindt Stimulation of the noradrenergic system during memory formation impairs extinction learning but not the disruption of reconsolidation Neuropsychopharmacology 37 2012 1204 1215
27. A.J. Guastella, R. Richardson, P.F. Lovibond, R.M. Rapee, J.E. Gaston, P. Mitchell, and M.R. Dadds A randomized controlled trial of the effect of D-cycloserine on enhancement of exposure therapy for social anxiety disorder Biol Psychiatry 63 2008 544 549
28. National Institute of Mental Health CGI: Clinical Global Impressions W. Guy, and R. Bonaro Manual for the ECDEU Assessment Battery 1970 National Institute of Mental Health Chevy Chase, MD
29. D.S. Charney, S.W. Woods, J.H. Krystal, L.M. Nagy, and G.R. Heninger Noradrenergic neuronal dysregulation in panic disorder: The effects of intravenous yohimbine and clonidine in panic disorder patients Acta Psychiatr Scand 86 1992 273 282
30. G.N. Gurguis, B.J. Vitton, and T.W. Uhde Behavioral, sympathetic and adrenocortical responses to yohimbine in panic disorder patients and normal controls Psychiatry Res 71 1997 27 39
31. S.M. Southwick, J.H. Krystal, J.D. Bremner, C.A. Morgan 3rd, A.L. Nicolaou, and L.M. Nagy et al. Noradrenergic and serotonergic function in posttraumatic stress disorder Arch Gen Psychiatry 54 1997 749 758
32. J.D. Bremner, R.B. Innis, C.K. Ng, L.H. Staib, R.M. Salomon, and R.A. Bronen et al. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder Arch Gen Psychiatry 54 1997 246 254
33. M.B. First, R.L. Spitzer, M. Gibbon, and J.B.W. Williams Structured Clinical Interview for DSM-IV Axis-I Disorders, Clinician Version 2001 American Psychiatric Publishing, Inc. Arlington, VA
34. M.R. Liebowitz Social phobia Mod Probl Pharmacopsychiatry 22 1987 141 173
35. D.M. Fresco, M.E. Coles, R.G. Heimberg, M.R. Liebowitz, S. Hami, M.B. Stein, and D. Goetz The Liebowitz Social Anxiety Scale: A comparison of the psychometric properties of self-report and clinician-administered formats Psychol Med 31 2001 1025 1035
36. M.R. Liebowitz, F. Schneier, R. Campeas, E. Hollander, J. Hatterer, and A. Fyer et al. Phenelzine vs atenolol in social phobia. A placebo-controlled comparison Arch Gen Psychiatry 49 1992 290 300
37. A.T. Beck, R.A. Steer, R. Ball, and W.F. Ranieri Comparison of Beck Depression Inventories-IA and -II in psychiatric outpatients J Pers Assess 67 1996 588 597
38. J Wolpe Psychotherapy by reciprocal inhibition Pavlov J Res Ther 3 1958 234 240
39. M.W. Otto, D.F. Tolin, N.M. Simon, G.D. Pearlson, S. Basden, and S.A. Meunier et al. Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder Biol Psychiatry 67 2010 365 370
40. C.D. Tart, P.R. Handelsman, L.B. Deboer, D. Rosenfield, M.H. Pollack, and S.G. Hofmann et al. Augmentation of exposure therapy with post-session administration of D-cycloserine J Psychiat Res 47 2013 168 174
41. C.J. Maas, and J.J. Hox Sufficient sample sizes for multilevel modeling Eur J Res Meth Behav Soc Sci 1 2005 86 92
42. T.D. Cook, and P.M. Steiner Case matching and the reduction of selection bias in quasi-experiments: The relative importance of pretest measures of outcome, of unreliable measurement, and of mode of data analysis Psychol Methods 15 2010 56 68
43. J.A. Smits, S.G. Hofmann, D. Rosenfield, L.B. Deboer, P.T. Costa, and N.M. Simon et al. D-Cycloserine augmentation of cognitive behavioral group therapy of social anxiety disorder: Prognostic and prescriptive variables [published online ahead of print August 12] J Consult Clin Psychol 2013
44. Y. Benjamini, and D. Yekutieli The control of the false discovery rate in multiple testing under dependency Ann Stat 29 2001 1165 1188
45. L.S. Aiken, and S.G. West Multiple Regression: Testing and Interpreting Interactions 1991 Sage Publications Newbury Park, CA
46. D.W. Hedges, B.L. Brown, and D.A. Shwalb A direct comparison of effect sizes from the Clinical Global Impression-Improvement scale to effect sizes from other rating scales in controlled trials of adult social anxiety disorder Hum Psychopharmacol 24 2009 35 40
47. R.A. Vasa, D.S. Pine, C.L. Masten, M. Vythilingam, C. Collin, and D.S. Charney et al. Effects of yohimbine and hydrocortisone on panic symptoms, autonomic responses, and attention to threat in healthy adults Psychopharmacology (Berl) 204 2009 445 455
48. D.S. Charney, S.W. Woods, and G.R. Heninger Noradrenergic function in generalized anxiety disorder: Effects of yohimbine in healthy subjects and patients with generalized anxiety disorder Psychiatry Res 27 1989 173 182