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Volumn 53, Issue 6, 2014, Pages 988-997

Therapeutic drug monitoring in rheumatic diseases: Utile or futile?

Author keywords

Allopurinol; Methotrexate; Rheumatology; Therapeutic drug monitoring

Indexed keywords

ALLOPURINOL; AZATHIOPRINE; COLCHICINE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; METHOTREXATE; OXIPURINOL; POLYGLUTAMIC ACID; TUMOR NECROSIS FACTOR INHIBITOR;

EID: 84900821492     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ket355     Document Type: Review
Times cited : (19)

References (53)
  • 1
    • 77950307115 scopus 로고    scopus 로고
    • Treating rheumatoid arthritis to target: recommendations of an international task force
    • Smolen J, Aletaha D, Bijlsma J et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis 2010;69:631-7.
    • (2010) Ann Rheum Dis , vol.69 , pp. 631-637
    • Smolen, J.1    Aletaha, D.2    Bijlsma, J.3
  • 2
    • 84859832981 scopus 로고    scopus 로고
    • 2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh J, Furst D, Bharat A et al. 2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res 2012;64:625-39.
    • (2012) Arthritis Care Res , vol.64 , pp. 625-639
    • Singh, J.1    Furst, D.2    Bharat, A.3
  • 3
    • 27744461917 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
    • Gearry R, Barclay M. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. J Gastroenterol Hepatol 2005;20: 1149-57.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1149-1157
    • Gearry, R.1    Barclay, M.2
  • 4
    • 15244349566 scopus 로고    scopus 로고
    • HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    • Hung S, Chung W, Liou L et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci USA 2005;102: 4134-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4134-4139
    • Hung, S.1    Chung, W.2    Liou, L.3
  • 5
    • 0029069283 scopus 로고
    • Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis
    • Lafforgue P, Monjanel-Mouterde S, Durand A et al. Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis. J Rheumatol 1995;22:844-9.
    • (1995) J Rheumatol , vol.22 , pp. 844-849
    • Lafforgue, P.1    Monjanel-Mouterde, S.2    Durand, A.3
  • 6
    • 55849140884 scopus 로고    scopus 로고
    • Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis
    • Dalrymple JM, Stamp LK, O'Donnell JL et al. Pharmacokinetics of oral methotrexate in patients with rheumatoid arthritis. Arthritis Rheum 2008;58:3299-308.
    • (2008) Arthritis Rheum , vol.58 , pp. 3299-3308
    • Dalrymple, J.M.1    Stamp, L.K.2    O'Donnell, J.L.3
  • 7
    • 68049089955 scopus 로고    scopus 로고
    • Determinants of red blood cell methotrexate polyglutamate concentrations in patients with rheumatoid arthritis on long-term MTX
    • Stamp LK, O'Donnell JL, Chapman PT et al. Determinants of red blood cell methotrexate polyglutamate concentrations in patients with rheumatoid arthritis on long-term MTX. Arthritis Rheum 2009;60:2248-56.
    • (2009) Arthritis Rheum , vol.60 , pp. 2248-2256
    • Stamp, L.K.1    O'Donnell, J.L.2    Chapman, P.T.3
  • 8
    • 78549273383 scopus 로고    scopus 로고
    • Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis
    • Dervieux T, Zablocki R, Kremer J. Red blood cell methotrexate polyglutamates emerge as a function of dosage intensity and route of administration during pulse methotrexate therapy in rheumatoid arthritis. Rheumatology 2010;49:2337-45.
    • (2010) Rheumatology , vol.49 , pp. 2337-2345
    • Dervieux, T.1    Zablocki, R.2    Kremer, J.3
  • 9
    • 0027305420 scopus 로고
    • Preliminary report: methotrexate-the relationship between dose and clinical effect
    • Seideman P. Preliminary report: methotrexate-the relationship between dose and clinical effect. Br J Rheum 1993;32:751-3.
    • (1993) Br J Rheum , vol.32 , pp. 751-753
    • Seideman, P.1
  • 10
    • 84894479843 scopus 로고    scopus 로고
    • Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types
    • Advance Access published 11 July 2013, doi: 10.1111/ bcp.12209.
    • Korell J, Duffull S, Dalrymple J et al. Comparison of intracellular methotrexate kinetics in red blood cells with the kinetics in other cell types. Br J Clin Pharmac 2013. Advance Access published 11 July 2013, doi: 10.1111/ bcp.12209.
    • (2013) Br J Clin Pharmac
    • Korell, J.1    Duffull, S.2    Dalrymple, J.3
  • 11
    • 84894460975 scopus 로고    scopus 로고
    • Measurement of methotrexate metabolites in peripheral blood mononuclear cells in juvenile idiopathic arthritis: a more relevant cellular biomarker for drug response?
    • van Haandel M, Leeder J, Becker M. Measurement of methotrexate metabolites in peripheral blood mononuclear cells in juvenile idiopathic arthritis: a more relevant cellular biomarker for drug response? Arthritis Rheum 2011;63:S95.
    • (2011) Arthritis Rheum , vol.63
    • van Haandel, M.1    Leeder, J.2    Becker, M.3
  • 12
    • 84875725735 scopus 로고    scopus 로고
    • Systematic review: antibodies and anti-TNF-a levels in inflammatory bowel disease
    • Chaparro M, Guerra I, Munoz-Linares P et al. Systematic review: antibodies and anti-TNF-a levels in inflammatory bowel disease. Aliment Pharmacol Ther 2012;35:971-86.
    • (2012) Aliment Pharmacol Ther , vol.35 , pp. 971-986
    • Chaparro, M.1    Guerra, I.2    Munoz-Linares, P.3
  • 13
    • 76649106655 scopus 로고    scopus 로고
    • Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis
    • Mulleman D, Méric J-C, Paintaud G et al. Infliximab concentration monitoring improves the control of disease activity in rheumatoid arthritis. Arthritis Res Ther 2009;11: R178.
    • (2009) Arthritis Res Ther , vol.11
    • Mulleman, D.1    Méric, J.-C.2    Paintaud, G.3
  • 14
    • 34548183243 scopus 로고    scopus 로고
    • Double-blinded infliximab dose escalation in patients with rheumatoid arthritis
    • Rahman M, Strusberg I, Geusens P et al. Double-blinded infliximab dose escalation in patients with rheumatoid arthritis. Ann Rheum Dis 2007;66:1233-38.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1233-1238
    • Rahman, M.1    Strusberg, I.2    Geusens, P.3
  • 15
    • 79953906254 scopus 로고    scopus 로고
    • Development of antidrug antibodies against adalimumab adn association with disease activity and treatment failure during long-term followup
    • Bartelds G, Krieckaert C, Nurmohamed M et al. Development of antidrug antibodies against adalimumab adn association with disease activity and treatment failure during long-term followup. JAMA 2011; 305:1460-68.
    • (2011) JAMA , vol.305 , pp. 1460-1468
    • Bartelds, G.1    Krieckaert, C.2    Nurmohamed, M.3
  • 16
    • 79959573331 scopus 로고    scopus 로고
    • Antibodies toward infliximab are associated with low infliximab concentration at treatment initiation and poor infliximab maintenance in rheumatic diseases
    • Ducourau E, Mulleman D, Paintaud G et al. Antibodies toward infliximab are associated with low infliximab concentration at treatment initiation and poor infliximab maintenance in rheumatic diseases. Arthritis Care Res 2011;13:R105.
    • (2011) Arthritis Care Res , vol.13
    • Ducourau, E.1    Mulleman, D.2    Paintaud, G.3
  • 17
    • 70449725246 scopus 로고    scopus 로고
    • Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis
    • Radstake T, Svenson M, Eijsbouts A et al. Formation of antibodies against infliximab and adalimumab strongly correlates with functional drug levels and clinical responses in rheumatoid arthritis. Ann Rheum Dis 2009; 68:1739-45.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1739-1745
    • Radstake, T.1    Svenson, M.2    Eijsbouts, A.3
  • 18
    • 84872060066 scopus 로고    scopus 로고
    • Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real clinical issue, a clinical perspective
    • Vincent F, Morand E, Murphy K et al. Antidrug antibodies (ADAb) to tumour necrosis factor (TNF)-specific neutralising agents in chronic inflammatory diseases: a real clinical issue, a clinical perspective. Ann Rheum Dis 2013;72: 165-78.
    • (2013) Ann Rheum Dis , vol.72 , pp. 165-178
    • Vincent, F.1    Morand, E.2    Murphy, K.3
  • 20
    • 67651229670 scopus 로고    scopus 로고
    • Increasing the infliximab dose in rheumatoid arthritis patients: a randomised, double blind study failed to confirm its efficacy
    • Pavelka K, Jarosóvá K, Suchý D et al. Increasing the infliximab dose in rheumatoid arthritis patients: a randomised, double blind study failed to confirm its efficacy. Ann Rheum Dis 2009;68:1285-89.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1285-1289
    • Pavelka, K.1    Jarosǒvá, K.2    Suchý, D.3
  • 21
    • 79955958563 scopus 로고    scopus 로고
    • Serum urate as a soluble biomarker in chronic gout-evidence that serum urate fulfils the OMERACT validation criteria for soluble biomarkers
    • Stamp L, Zhu X, Dalbeth N et al. Serum urate as a soluble biomarker in chronic gout-evidence that serum urate fulfils the OMERACT validation criteria for soluble biomarkers. Semin Arthritis Rheum 2011;40:483-500.
    • (2011) Semin Arthritis Rheum , vol.40 , pp. 483-500
    • Stamp, L.1    Zhu, X.2    Dalbeth, N.3
  • 22
    • 33746717478 scopus 로고    scopus 로고
    • Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricaemia in patients with gout
    • Dalbeth N, Kumar S, Stamp L et al. Dose adjustment of allopurinol according to creatinine clearance does not provide adequate control of hyperuricaemia in patients with gout. J Rheumatol 2006;33:1646-50.
    • (2006) J Rheumatol , vol.33 , pp. 1646-1650
    • Dalbeth, N.1    Kumar, S.2    Stamp, L.3
  • 23
    • 0022449609 scopus 로고
    • Clinical pharmacokinetics of allopurinol
    • Murrell G, Rapeport W. Clinical pharmacokinetics of allopurinol. Clin Pharmacokinet 1986;11:343-53.
    • (1986) Clin Pharmacokinet , vol.11 , pp. 343-353
    • Murrell, G.1    Rapeport, W.2
  • 24
    • 0021366307 scopus 로고
    • Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency
    • Hande K, Noone R, Stone W. Severe allopurinol toxicity. Description and guidelines for prevention in patients with renal insufficiency. Am J Med 1984;76:47-56.
    • (1984) Am J Med , vol.76 , pp. 47-56
    • Hande, K.1    Noone, R.2    Stone, W.3
  • 25
    • 0023473492 scopus 로고
    • Plasma oxypurinol concentrations during allopurinol therapy
    • Emmerson B, Gordon R, Cross M et al. Plasma oxypurinol concentrations during allopurinol therapy. Br J Rheumatol 1987;26:445-9.
    • (1987) Br J Rheumatol , vol.26 , pp. 445-449
    • Emmerson, B.1    Gordon, R.2    Cross, M.3
  • 26
    • 0025054352 scopus 로고
    • Dosage prescribing and plasma oxypurinol levels in patients receiving allopurinol therapy
    • Peterson G, Boyle R, Francis H et al. Dosage prescribing and plasma oxypurinol levels in patients receiving allopurinol therapy. Eur J Clin Pharmacol 1990; 39:419-21.
    • (1990) Eur J Clin Pharmacol , vol.39 , pp. 419-421
    • Peterson, G.1    Boyle, R.2    Francis, H.3
  • 27
    • 80052037135 scopus 로고    scopus 로고
    • Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level
    • Stamp L, Barclay M, O'Donnell J et al. Relationship between serum urate and plasma oxypurinol in the management of gout: determination of minimum plasma oxypurinol concentration to achieve a target serum urate level. Clin Pharm Ther 2011;90:392-8.
    • (2011) Clin Pharm Ther , vol.90 , pp. 392-398
    • Stamp, L.1    Barclay, M.2    O'Donnell, J.3
  • 28
    • 44449090511 scopus 로고    scopus 로고
    • Higher therapeutic plasma oxypurinol concentrations might be required for gouty patients with chronic kidney disease
    • Panomvana D, Sripradit S, Angthararak S. Higher therapeutic plasma oxypurinol concentrations might be required for gouty patients with chronic kidney disease. J Clin Rheumatol 2008;14:6-11.
    • (2008) J Clin Rheumatol , vol.14 , pp. 6-11
    • Panomvana, D.1    Sripradit, S.2    Angthararak, S.3
  • 29
    • 0024794435 scopus 로고
    • The allopurinol hypersensitivity syndrome: its relation to plasma oxypurinol levels
    • Casas E, Puig J, Mateos F et al. The allopurinol hypersensitivity syndrome: its relation to plasma oxypurinol levels. Adv Exp Med Biol 1989;253A:257-60.
    • (1989) Adv Exp Med Biol , vol.253 , Issue.A , pp. 257-260
    • Casas, E.1    Puig, J.2    Mateos, F.3
  • 30
    • 0024324603 scopus 로고
    • Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity
    • Puig J, Casas E, Ramos T et al. Plasma oxypurinol concentration in a patient with allopurinol hypersensitivity. J Rheumatol 1989;16:842-4.
    • (1989) J Rheumatol , vol.16 , pp. 842-844
    • Puig, J.1    Casas, E.2    Ramos, T.3
  • 31
    • 0029069615 scopus 로고
    • Allopurinol hypersensitivity syndrome revisited
    • Elasy T, Kaminsky D, Tracy M et al. Allopurinol hypersensitivity syndrome revisited. West J Med 1995;162: 360-1.
    • (1995) West J Med , vol.162 , pp. 360-361
    • Elasy, T.1    Kaminsky, D.2    Tracy, M.3
  • 32
    • 0024892097 scopus 로고
    • Pharmacokinetics/ bioavailability of colchicine in healthy male volunteers
    • Achtert G, Scherrmann J, Christen M. Pharmacokinetics/ bioavailability of colchicine in healthy male volunteers. Eur J Drug Metab Pharmacokinet 1989;14:317-22.
    • (1989) Eur J Drug Metab Pharmacokinet , vol.14 , pp. 317-322
    • Achtert, G.1    Scherrmann, J.2    Christen, M.3
  • 34
    • 84900805572 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. New safety information for colchicine, (30 October 2013, date last accessed)
    • U.S. Food and Drug Administration. New safety information for colchicine. 2009. http://www.fda.gov/Drugs/DrugSafety/ PostmarketDrugSafetyInformationforPatientsandProviders/ DrugSafetyInformationforHeathcareProfessionals/ucm 174315.htm (30 October 2013, date last accessed).
    • (2009)
  • 35
    • 79959982529 scopus 로고    scopus 로고
    • New dosing guidelines for colchicine to avoid toxicity when used with Ca2+ channel blockers: the potent P-Gp/CYP3A4 inhibitor verapamil increases maximal concentration of single dose colchicine by 30% and exposure by -100% in healthy subjects
    • Terkeltaub R, Furst D, Kook K et al. New dosing guidelines for colchicine to avoid toxicity when used with Ca2+ channel blockers: the potent P-Gp/CYP3A4 inhibitor verapamil increases maximal concentration of single dose colchicine by 30% and exposure by -100% in healthy subjects. Arthritis Rheum 2009;60:S414.
    • (2009) Arthritis Rheum , vol.60
    • Terkeltaub, R.1    Furst, D.2    Kook, K.3
  • 36
    • 0031032187 scopus 로고    scopus 로고
    • Colchcine poisoning: report of a fatal case and presentation of HPLC procedure for body fluid and tissue analysis
    • Kintz P, Jamey C, Tracqui A et al. Colchcine poisoning: report of a fatal case and presentation of HPLC procedure for body fluid and tissue analysis. J Anal Toxicol 1997;21: 70-2.
    • (1997) J Anal Toxicol , vol.21 , pp. 70-72
    • Kintz, P.1    Jamey, C.2    Tracqui, A.3
  • 37
    • 33745608050 scopus 로고    scopus 로고
    • Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases
    • Schedel J, Goddde A, Schütz E et al. Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases. Ann N Y Acad Sci 2006;1069: 477-91.
    • (2006) Ann N Y Acad Sci , vol.1069 , pp. 477-491
    • Schedel, J.1    Goddde, A.2    Schütz, E.3
  • 38
    • 0027476298 scopus 로고
    • 6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment
    • Schmiegelow K, Kreigbaum N. 6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment. Ann Rheum Dis 1993;52: 152-4.
    • (1993) Ann Rheum Dis , vol.52 , pp. 152-154
    • Schmiegelow, K.1    Kreigbaum, N.2
  • 39
    • 84859992864 scopus 로고    scopus 로고
    • Low blood concentration of hydroxychloroquine in patients with refractory cutaneous lupus erythematosus
    • Francès C, Cosnes A, Duhaut P et al. Low blood concentration of hydroxychloroquine in patients with refractory cutaneous lupus erythematosus. Arch Dermatol 2012; 148:479-84.
    • (2012) Arch Dermatol , vol.148 , pp. 479-484
    • Francès, C.1    Cosnes, A.2    Duhaut, P.3
  • 40
    • 33750302628 scopus 로고    scopus 로고
    • Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus
    • Costedoat-Chalumeau N, Amoura Z, Hulot J et al. Low blood concentration of hydroxychloroquine is a marker for and predictor of disease exacerbations in patients with systemic lupus erythematosus. Arthritis Rheum 2006;54: 3284-90.
    • (2006) Arthritis Rheum , vol.54 , pp. 3284-3290
    • Costedoat-Chalumeau, N.1    Amoura, Z.2    Hulot, J.3
  • 41
    • 0033023168 scopus 로고    scopus 로고
    • Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis
    • Angelis-Stoforidis P, Vajda FJE, Christophidis N. Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis. Clin Exp Rheumatol 1999; 17:313-20.
    • (1999) Clin Exp Rheumatol , vol.17 , pp. 313-320
    • Angelis-Stoforidis, P.1    Vajda, F.J.E.2    Christophidis, N.3
  • 42
    • 4444376725 scopus 로고    scopus 로고
    • Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
    • Dervieux T, Furst D, Lein DO et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004;50:2766-74.
    • (2004) Arthritis Rheum , vol.50 , pp. 2766-2774
    • Dervieux, T.1    Furst, D.2    Lein, D.O.3
  • 43
    • 33750352061 scopus 로고    scopus 로고
    • Pharmacogenomic and metabolic markers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis
    • Dervieux T, Greenstein N, Kremer J. Pharmacogenomic and metabolic markers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum 2006;54: 3095-103.
    • (2006) Arthritis Rheum , vol.54 , pp. 3095-3103
    • Dervieux, T.1    Greenstein, N.2    Kremer, J.3
  • 44
    • 54049158589 scopus 로고    scopus 로고
    • Patients with rheumatoid arthritis treated with methotrexate (MTX): concentrations of steady-state erythrocyte MTX correlate to plasma concentrations and clinical efficacy
    • Hornung N, Ellingsen T, Attermann J et al. Patients with rheumatoid arthritis treated with methotrexate (MTX): concentrations of steady-state erythrocyte MTX correlate to plasma concentrations and clinical efficacy. J Rheumatol 2008;35:1709-15.
    • (2008) J Rheumatol , vol.35 , pp. 1709-1715
    • Hornung, N.1    Ellingsen, T.2    Attermann, J.3
  • 45
    • 75749135305 scopus 로고    scopus 로고
    • Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients on longterm MTX therapy
    • Stamp LK, O'Donnell JL, Chapman PT et al. Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients on longterm MTX therapy. Arthritis Rheum 2010;62:359-68.
    • (2010) Arthritis Rheum , vol.62 , pp. 359-368
    • Stamp, L.K.1    O'Donnell, J.L.2    Chapman, P.T.3
  • 46
    • 78650793942 scopus 로고    scopus 로고
    • The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response
    • Becker M, Gaedigk R, Van Haandel L et al. The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response. Arthritis Rheum 2011;63:276-85.
    • (2011) Arthritis Rheum , vol.63 , pp. 276-285
    • Becker, M.1    Gaedigk, R.2    Van Haandel, L.3
  • 47
    • 84863751959 scopus 로고    scopus 로고
    • A short chain methotrexate polyglutamate as outcome parameter in rheumatoid arthritis patients receiving methotrexate
    • Hobl E-L, Jilma B, Erlacher L et al. A short chain methotrexate polyglutamate as outcome parameter in rheumatoid arthritis patients receiving methotrexate. Clin Exp Rheumatol 2012;30:156-63.
    • (2012) Clin Exp Rheumatol , vol.30 , pp. 156-163
    • Hobl, E.-L.1    Jilma, B.2    Erlacher, L.3
  • 48
    • 0036269445 scopus 로고    scopus 로고
    • The relationship of serum infliximab concentrations to clinical improvement in rheumatoid arthritis results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial
    • St. Clair E, Wagner C, Fasanmade A et al. The relationship of serum infliximab concentrations to clinical improvement in rheumatoid arthritis results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002;46:1451-59.
    • (2002) Arthritis Rheum , vol.46 , pp. 1451-1459
    • St. Clair, E.1    Wagner, C.2    Fasanmade, A.3
  • 49
    • 17644382690 scopus 로고    scopus 로고
    • Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis
    • Wolbink G, Voskuyl A, Lems W et al. Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritis. Ann Rheum Dis 2005; 64:704-7.
    • (2005) Ann Rheum Dis , vol.64 , pp. 704-707
    • Wolbink, G.1    Voskuyl, A.2    Lems, W.3
  • 50
    • 77950213411 scopus 로고    scopus 로고
    • Trough infliximab concentrations predict efficacy and sustained control of disease activity in rheumatoid arthritis
    • Mulleman D, Lin D, Ducourau E et al. Trough infliximab concentrations predict efficacy and sustained control of disease activity in rheumatoid arthritis. Ther Drug Monit 2010;32:232-6.
    • (2010) Ther Drug Monit , vol.32 , pp. 232-236
    • Mulleman, D.1    Lin, D.2    Ducourau, E.3
  • 51
    • 34347267600 scopus 로고    scopus 로고
    • Clinical response to adalimumab: relationship to antiadalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis
    • Bartelds G, Wijbrandts C, Nurmohamed M et al. Clinical response to adalimumab: relationship to antiadalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann Rheum Dis 2007;66:921-6.
    • (2007) Ann Rheum Dis , vol.66 , pp. 921-926
    • Bartelds, G.1    Wijbrandts, C.2    Nurmohamed, M.3
  • 52
    • 82955189865 scopus 로고    scopus 로고
    • Patients non-responding to etanercept obtain lower etanercept concentrations compared with responding patients
    • Jamnitski A, Krieckaert C, Nurmohamed M et al. Patients non-responding to etanercept obtain lower etanercept concentrations compared with responding patients. Ann Rheum Dis 2012;71:88-91.
    • (2012) Ann Rheum Dis , vol.71 , pp. 88-91
    • Jamnitski, A.1    Krieckaert, C.2    Nurmohamed, M.3
  • 53
    • 84864546448 scopus 로고    scopus 로고
    • Etanercept concentrations in patients with rheuamtoid arthritis and its potential influence on treatment decisions: a pilot study
    • Daien C, Daien V, Parussini E et al. Etanercept concentrations in patients with rheuamtoid arthritis and its potential influence on treatment decisions: a pilot study. J Rheumatol 2012;39:1533-8.
    • (2012) J Rheumatol , vol.39 , pp. 1533-1538
    • Daien, C.1    Daien, V.2    Parussini, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.