-
1
-
-
0023279602
-
Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy and safety
-
Tugwell P, Bennet K, Gent M. Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy and safety. Ann Intern Med 1987;107:358-66.
-
(1987)
Ann Intern Med
, vol.107
, pp. 358-366
-
-
Tugwell, P.1
Bennet, K.2
Gent, M.3
-
2
-
-
0031887318
-
Longterm prospective study of methotrexate in rheumatoid arthritis: Conclusion after 132 months of therapy
-
Weinblatt ME, Maier AL, Fraser PA, et al. Longterm prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy. J Rheumatol 1998;25:238-42.
-
(1998)
J Rheumatol
, vol.25
, pp. 238-242
-
-
Weinblatt, M.E.1
Maier, A.L.2
Fraser, P.A.3
-
3
-
-
0035287209
-
Old and new drugs used in rheumatoid arthritis: A historical perspective. Part 1: the older drugs
-
Case JP. Old and new drugs used in rheumatoid arthritis: a historical perspective. Part 1: the older drugs. Am J Ther 2001;8:123-43.
-
(2001)
Am J Ther
, vol.8
, pp. 123-143
-
-
Case, J.P.1
-
4
-
-
0030711570
-
Methotrexate use in rheumatoid arthritis
-
O'Dell JR. Methotrexate use in rheumatoid arthritis. Rheum Dis Clin North Am 1997;23:779-96.
-
(1997)
Rheum Dis Clin North Am
, vol.23
, pp. 779-796
-
-
O'Dell, J.R.1
-
5
-
-
0033848342
-
Longterm methotrexate use in rheumatoid arthritis: 12 year followup of 460 patients treated in community practice
-
Wluka A, Buchbinder R, Mylvaganam A, et al. Longterm methotrexate use in rheumatoid arthritis: 12 year followup of 460 patients treated in community practice. J Rheumatol 2000;27:1864-71.
-
(2000)
J Rheumatol
, vol.27
, pp. 1864-1871
-
-
Wluka, A.1
Buchbinder, R.2
Mylvaganam, A.3
-
6
-
-
0242693163
-
Longterm observational study of methotrexate use in a Dutch cohort of 1022 patients with rheumatoid arthritis
-
Hoekstra M, van de Laar MA, Bernelot Moens HJ, et al. Longterm observational study of methotrexate use in a Dutch cohort of 1022 patients with rheumatoid arthritis. J Rheumatol 2003;30:2325-9.
-
(2003)
J Rheumatol
, vol.30
, pp. 2325-2329
-
-
Hoekstra, M.1
van de Laar, M.A.2
Bernelot Moens, H.J.3
-
7
-
-
22944470530
-
Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis
-
Cronstein BN. Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev 2005;57:163-72.
-
(2005)
Pharmacol Rev
, vol.57
, pp. 163-172
-
-
Cronstein, B.N.1
-
8
-
-
0022410582
-
Polyglutamation of methotrexate. Is methotrexate a prodrug?
-
Chabner BA, Allegra CJ, Curt GA, et al. Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest 1985;76:907-12.
-
(1985)
J Clin Invest
, vol.76
, pp. 907-912
-
-
Chabner, B.A.1
Allegra, C.J.2
Curt, G.A.3
-
9
-
-
2342499810
-
Toward a better understanding of methotrexate
-
Kremer JM. Toward a better understanding of methotrexate. Arthritis Rheum 2004;50:1370-82.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1370-1382
-
-
Kremer, J.M.1
-
10
-
-
0027957782
-
The mechanism of action of methotrexate in rheumatoid arthritis: The search continues
-
Kremer JM. The mechanism of action of methotrexate in rheumatoid arthritis: the search continues. J Rheumatol 1994;21:1-5.
-
(1994)
J Rheumatol
, vol.21
, pp. 1-5
-
-
Kremer, J.M.1
-
11
-
-
0031950185
-
Methotrexate in rheumatoid arthritis: An update with focus on mechanisms involved in toxicity
-
Van Ede AE, Laan RFJM, Blom HJ, et al. Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity. Semin Arthritis Rheum 1998;27:277-92.
-
(1998)
Semin Arthritis Rheum
, vol.27
, pp. 277-292
-
-
Van Ede, A.E.1
Laan, R.F.J.M.2
Blom, H.J.3
-
12
-
-
0035985787
-
Molecular action of methotrexate in inflammatory diseases
-
Chan ES, Cronstein BN. Molecular action of methotrexate in inflammatory diseases. Arthritis Res 2002;4:266-73.
-
(2002)
Arthritis Res
, vol.4
, pp. 266-273
-
-
Chan, E.S.1
Cronstein, B.N.2
-
13
-
-
0030664737
-
The mechanism of action of methotrexate
-
Cronstein BN. The mechanism of action of methotrexate. Rheum Dis Clin North Am 1997;23:739-55.
-
(1997)
Rheum Dis Clin North Am
, vol.23
, pp. 739-755
-
-
Cronstein, B.N.1
-
14
-
-
12344262977
-
Adenosine and methotrexate polyglutamate concentrations in patients with juvenile arthritis
-
Dolezalova P, Krijt J, Chladek J, et al. Adenosine and methotrexate polyglutamate concentrations in patients with juvenile arthritis. Rheumatology Oxford 2005;44:74-9.
-
(2005)
Rheumatology Oxford
, vol.44
, pp. 74-79
-
-
Dolezalova, P.1
Krijt, J.2
Chladek, J.3
-
15
-
-
0032518281
-
Methotrexate and sulfasalazine promotes adenosine release by a mechanism that requires ecto'-5'-nucleotidase-mediated conversion of adenosine nucleotides
-
Morabito L, Montesinos MC, Schreibman DM, et al. Methotrexate and sulfasalazine promotes adenosine release by a mechanism that requires ecto'-5'-nucleotidase-mediated conversion of adenosine nucleotides. J Clin Invest 1998;101:295-300.
-
(1998)
J Clin Invest
, vol.101
, pp. 295-300
-
-
Morabito, L.1
Montesinos, M.C.2
Schreibman, D.M.3
-
16
-
-
0029898079
-
Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis
-
Bannwarth B, Pehourcq F, Schaeverbeke T, et al. Clinical pharmacokinetics of low-dose pulse methotrexate in rheumatoid arthritis. Clin Pharmacokinet 1996;30:194-210.
-
(1996)
Clin Pharmacokinet
, vol.30
, pp. 194-210
-
-
Bannwarth, B.1
Pehourcq, F.2
Schaeverbeke, T.3
-
17
-
-
0028241936
-
Methotrexate - the relationship between dose and clinical effect
-
Seideman P. Methotrexate - the relationship between dose and clinical effect. Arthritis Rheum 1994;37:830-3.
-
(1994)
Arthritis Rheum
, vol.37
, pp. 830-833
-
-
Seideman, P.1
-
18
-
-
0019486066
-
Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug
-
Kamen BA, Nylen PA, Camitta BM, et al. Methotrexate accumulation and folate depletion in cells as a possible mechanism of chronic toxicity to the drug. Br J Haematol 1981;49:355-60.
-
(1981)
Br J Haematol
, vol.49
, pp. 355-360
-
-
Kamen, B.A.1
Nylen, P.A.2
Camitta, B.M.3
-
19
-
-
0033023168
-
Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis
-
Angelis-Stoforidis P, Vajda FJ, Christophidis N. Methotrexate polyglutamate levels in circulating erythrocytes and polymorphs correlate with clinical efficacy in rheumatoid arthritis. Clin Exp Rheumatol 1999;17:313-20.
-
(1999)
Clin Exp Rheumatol
, vol.17
, pp. 313-320
-
-
Angelis-Stoforidis, P.1
Vajda, F.J.2
Christophidis, N.3
-
20
-
-
4444376725
-
Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis
-
Dervieux T, Furst D, Lein DO, et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004;50:2766-74.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 2766-2774
-
-
Dervieux, T.1
Furst, D.2
Lein, D.O.3
-
21
-
-
0036789754
-
Longitudinal measurement of methotrexate liver concentrations does not correlate with liver damage, clinical efficacy, or toxicity during a 3.5 year double blind study in rheumatoid arthritis
-
Fathi NH, Mitros F, Hoffman J, et al. Longitudinal measurement of methotrexate liver concentrations does not correlate with liver damage, clinical efficacy, or toxicity during a 3.5 year double blind study in rheumatoid arthritis. J Rheumatol 2002;29:2092-8.
-
(2002)
J Rheumatol
, vol.29
, pp. 2092-2098
-
-
Fathi, N.H.1
Mitros, F.2
Hoffman, J.3
-
22
-
-
0021920917
-
Measurements of red blood cell methotrexate concentrations and lymphocyte subsets during therapy of rheumatoid arthritis
-
Duby S, Karsh J, Prchal JF, et al. Measurements of red blood cell methotrexate concentrations and lymphocyte subsets during therapy of rheumatoid arthritis. Clin Exp Rheumatol 1985;3:5-9.
-
(1985)
Clin Exp Rheumatol
, vol.3
, pp. 5-9
-
-
Duby, S.1
Karsh, J.2
Prchal, J.F.3
-
23
-
-
0034541414
-
Erythrocyte- methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis
-
Kristensen K, Nielsen S, Karup Pedersen F, et al. Erythrocyte- methotrexate and disease activity in children treated with oral methotrexate for juvenile chronic arthritis. Scand J Rheumatol 2000;29:187-9.
-
(2000)
Scand J Rheumatol
, vol.29
, pp. 187-189
-
-
Kristensen, K.1
Nielsen, S.2
Karup Pedersen, F.3
-
24
-
-
23444443994
-
Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: Results of a multicentred cross sectional observational study
-
Dervieux T, Furst D, Lein DO, et al. Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann Rheum Dis 2005;64:1180-5.
-
(2005)
Ann Rheum Dis
, vol.64
, pp. 1180-1185
-
-
Dervieux, T.1
Furst, D.2
Lein, D.O.3
-
25
-
-
33750352061
-
Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis
-
Dervieux T, Greenstein N, Kremer J. Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum 2006;54:3095-103.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3095-3103
-
-
Dervieux, T.1
Greenstein, N.2
Kremer, J.3
-
27
-
-
0024521184
-
Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients
-
Herman RA, Vengpedersen P, Hoffman J, et al. Pharmacokinetics of low-dose methotrexate in rheumatoid arthritis patients. J Pharm Sci 1989;78:165-71.
-
(1989)
J Pharm Sci
, vol.78
, pp. 165-171
-
-
Herman, R.A.1
Vengpedersen, P.2
Hoffman, J.3
-
28
-
-
0024365416
-
Methotrexate pharamcokinetics in patients with rheumatoid arthritis
-
Sinnet MJ, Groff GD, Raddatz DA, et al. Methotrexate pharamcokinetics in patients with rheumatoid arthritis. J Rheumatol 1989;16:745-8.
-
(1989)
J Rheumatol
, vol.16
, pp. 745-748
-
-
Sinnet, M.J.1
Groff, G.D.2
Raddatz, D.A.3
-
29
-
-
0025190680
-
Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis
-
Brooks PJ, Spruill WJ, Parish RC, et al. Pharmacokinetics of methotrexate administered by intramuscular and subcutaneous injections in patients with rheumatoid arthritis. Arthritis Rheum 1990;33:91-4.
-
(1990)
Arthritis Rheum
, vol.33
, pp. 91-94
-
-
Brooks, P.J.1
Spruill, W.J.2
Parish, R.C.3
-
30
-
-
0026502732
-
The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis
-
Tracy TS, Krohn K, Jones DR, et al. The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. Eur J Clin Pharmacol 1992;42:121-5.
-
(1992)
Eur J Clin Pharmacol
, vol.42
, pp. 121-125
-
-
Tracy, T.S.1
Krohn, K.2
Jones, D.R.3
-
31
-
-
0028365380
-
Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis
-
Tracy TS, Worster T, Bradley JD, et al. Methotrexate disposition following concomitant administration of ketoprofen, piroxicam and flurbiprofen in patients with rheumatoid arthritis. Br J Clin Pharmacol 1994;37:453-6.
-
(1994)
Br J Clin Pharmacol
, vol.37
, pp. 453-456
-
-
Tracy, T.S.1
Worster, T.2
Bradley, J.D.3
-
32
-
-
0028874225
-
Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: Association with significant decreases in creatinine clearance and renal clearance of the drug after 6 months of therapy
-
Kremer JM, Petrillo GF, Hamilton RA. Pharmacokinetics and renal function in patients with rheumatoid arthritis receiving a standard dose of oral weekly methotrexate: association with significant decreases in creatinine clearance and renal clearance of the drug after 6 months of therapy. J Rheumatol 1995;22:38-40.
-
(1995)
J Rheumatol
, vol.22
, pp. 38-40
-
-
Kremer, J.M.1
Petrillo, G.F.2
Hamilton, R.A.3
-
33
-
-
0028857401
-
Examination of pharmacokinetic variables in a cohort of patients with rheumatoid arthritis beginning therapy with methotrexate compared with a cohort receiving the drug for a mean of 81 months
-
Kremer JM, Petrillo GF, Hamilton RA. Examination of pharmacokinetic variables in a cohort of patients with rheumatoid arthritis beginning therapy with methotrexate compared with a cohort receiving the drug for a mean of 81 months. J Rheumatol 1995;22:41-4.
-
(1995)
J Rheumatol
, vol.22
, pp. 41-44
-
-
Kremer, J.M.1
Petrillo, G.F.2
Hamilton, R.A.3
-
34
-
-
0031661580
-
The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis
-
Godfrey C, Sweeney K, Miller K, et al. The population pharmacokinetics of long-term methotrexate in rheumatoid arthritis. Br J Clin Pharmacol 1998;46:369-76.
-
(1998)
Br J Clin Pharmacol
, vol.46
, pp. 369-376
-
-
Godfrey, C.1
Sweeney, K.2
Miller, K.3
-
35
-
-
20444389821
-
Pharmacokinetics and efficacy of low-dose methotrexate in patients with rheumatoid arthritis
-
Hiraga Y, Yuhki Y, Itoh K, Tadano K, Takahashi Y, Mukai M. Pharmacokinetics and efficacy of low-dose methotrexate in patients with rheumatoid arthritis. Mod Rheumatol 2004;14:135-42.
-
(2004)
Mod Rheumatol
, vol.14
, pp. 135-142
-
-
Hiraga, Y.1
Yuhki, Y.2
Itoh, K.3
Tadano, K.4
Takahashi, Y.5
Mukai, M.6
-
36
-
-
0023945481
-
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis
-
Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
-
(1988)
Arthritis Rheum
, vol.31
, pp. 315-324
-
-
Arnett, F.C.1
Edworthy, S.M.2
Bloch, D.A.3
-
37
-
-
0027526252
-
The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis
-
Seideman P, Beck O, Eksborg S, et al. The pharmacokinetics of methotrexate and its 7-hydroxy metabolite in patients with rheumatoid arthritis. Br J Clin Pharmacol 1993;35:409-12.
-
(1993)
Br J Clin Pharmacol
, vol.35
, pp. 409-412
-
-
Seideman, P.1
Beck, O.2
Eksborg, S.3
-
39
-
-
84960582159
-
Efficacy of methotrexate in rheumatoid arthritis
-
Weinblatt ME. Efficacy of methotrexate in rheumatoid arthritis. Br J Rheumatol 1995;34 Suppl 2:43-8.
-
(1995)
Br J Rheumatol
, vol.34
, Issue.SUPPL. 2
, pp. 43-48
-
-
Weinblatt, M.E.1
-
40
-
-
0030785828
-
Adverse drug reactions of DMARDs and DC-ARTs in rheumatoid arthritis
-
Wolfe F. Adverse drug reactions of DMARDs and DC-ARTs in rheumatoid arthritis. Clin Exp Rheumatol 1997;15 Suppl 17:S75-81.
-
(1997)
Clin Exp Rheumatol
, vol.15
, Issue.SUPPL. 17
-
-
Wolfe, F.1
-
41
-
-
0034116168
-
Factors influencing length of time taking methotrexate in rheumatoid arthritis
-
Ortendahl M, Schettler JD, Fries JF. Factors influencing length of time taking methotrexate in rheumatoid arthritis. J Rheumatol 2000;27:1139-47.
-
(2000)
J Rheumatol
, vol.27
, pp. 1139-1147
-
-
Ortendahl, M.1
Schettler, J.D.2
Fries, J.F.3
-
42
-
-
0025125626
-
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis
-
Skeith KJ, Russell AS, Jamali F, et al. Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis. J Rheumatol 1990;17:1008-10.
-
(1990)
J Rheumatol
, vol.17
, pp. 1008-1010
-
-
Skeith, K.J.1
Russell, A.S.2
Jamali, F.3
-
43
-
-
0025269503
-
Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis
-
Stewart CF, Fleming RA, Arkin CR, et al. Coadministration of naproxen and low-dose methotrexate in patients with rheumatoid arthritis. Clin Pharmacol Ther 1990;47:540-6.
-
(1990)
Clin Pharmacol Ther
, vol.47
, pp. 540-546
-
-
Stewart, C.F.1
Fleming, R.A.2
Arkin, C.R.3
-
44
-
-
0023735704
-
Methotrexate kinetics in rheumatoid arthritis: Is there an interaction with nonsteroidal antiinflammatory drugs?
-
Ahern M, Booth J, Loxton A, et al. Methotrexate kinetics in rheumatoid arthritis: is there an interaction with nonsteroidal antiinflammatory drugs? J Rheumatol 1988;15:1356-60.
-
(1988)
J Rheumatol
, vol.15
, pp. 1356-1360
-
-
Ahern, M.1
Booth, J.2
Loxton, A.3
-
46
-
-
0029069283
-
Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis
-
Lafforgue P, Monjanel-Mouterde S, Durand A, et al. Lack of correlation between pharmacokinetics and efficacy of low dose methotrexate in patients with rheumatoid arthritis. J Rheumatol 1995;22:844-9.
-
(1995)
J Rheumatol
, vol.22
, pp. 844-849
-
-
Lafforgue, P.1
Monjanel-Mouterde, S.2
Durand, A.3
-
47
-
-
0029157611
-
Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients
-
Bologna C, Anaya JM, Bressolle F, et al. Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients. Clin Exp Rheumatol 1995;13:465-70.
-
(1995)
Clin Exp Rheumatol
, vol.13
, pp. 465-470
-
-
Bologna, C.1
Anaya, J.M.2
Bressolle, F.3
-
48
-
-
0027960362
-
Methotrexate in rheumatoid arthritis - a limited sampling strategy for estimation of the area under the plasma concentration versus time curve
-
Eksborg S, Albertioni F, Beck O, Peterson C, Seideman P. Methotrexate in rheumatoid arthritis - a limited sampling strategy for estimation of the area under the plasma concentration versus time curve. Ther Drug Monit 1994;16:560-3.
-
(1994)
Ther Drug Monit
, vol.16
, pp. 560-563
-
-
Eksborg, S.1
Albertioni, F.2
Beck, O.3
Peterson, C.4
Seideman, P.5
|