Synthesis of isoquinolinone-based tricycles as novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 12, 2014, Pages 2669-2673

  Chen, Jianyang ^a   Peng, Haixia ^a   He, Jinxue ^a   Huan, Xiajuan ^a   Miao, Zehong ^a   Yang, Chunhao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antitumor; Isoquinolinone based tricycles; PARP 1 inhibitors

Indexed keywords

CYTOTOXIC AGENT; ISOQUINOLINE DERIVATIVE; ISOQUINOLINONE BASED TRICYCLE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; OLAPARIB; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; ENZYME INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

ARTICLE; BREAST CANCER CELL LINE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION; ANTIPROLIFERATIVE ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SOLUBILITY; ENZYMATIC ASSAY; ENZYME INHIBITOR INTERACTION; IC50; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVATION; SYNTHESIS;

ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; MOLECULAR STRUCTURE; POLY(ADP-RIBOSE) POLYMERASES;

EID: 84900816000     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.04.061     Document Type: Article

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