Dynamic contrast enhanced MRI parameters and tumor cellularity in a rat model of cerebral glioma at 7 T

Magnetic Resonance in Medicine

Volumn 71, Issue 6, 2014, Pages 2206-2214

  Aryal, Madhava P ^a,b   Nagaraja, Tavarekere N ^b   Keenan, Kelly A ^b   Bagher Ebadian, Hassan ^a,b   Panda, Swayamprava ^b   Brown, Stephen L ^b   Cabral, Glauber ^b   Fenstermacher, Joseph D ^b,c   Ewing, James R ^a,b  

^a OAKLAND UNIVERSITY   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

DCE MRI; distribution volume; dual echo gradient echo sequence; interstitial volume; Logan plot; longitudinal relaxation rate; tumor cellularity

Indexed keywords

TUMORS;

DCE-MRI; DISTRIBUTION VOLUME; GRADIENT ECHO SEQUENCES; INTERSTITIAL VOLUME; LOGAN PLOT; LONGITUDINAL RELAXATION;

MAGNETIC RESONANCE IMAGING;

GADOLINIUM; HEMATOXYLIN; CONTRAST MEDIUM; GADOLINIUM PENTETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TISSUE; CELL COUNT; CELL COUNTING; DISTRIBUTION VOLUME; DYNAMIC CONTRAST ENHANCED MAGNETIC RESONANCE IMAGING; GLIOMA; INTERSTITIAL VOLUME FRACTION; MICROVASCULATURE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE RAT; ONCOLOGICAL PARAMETERS; PLASMA VOLUME; RADIOLOGICAL PARAMETERS; RAT; TUMOR CELLULARITY; TUMOR XENOGRAFT; ALGORITHM; ANIMAL; BRAIN TUMOR; DIAGNOSTIC USE; DISEASE MODEL; ECHO PLANAR IMAGING; PATHOLOGY; PROCEDURES; XENOGRAFT;

ALGORITHMS; ANIMALS; BRAIN NEOPLASMS; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; ECHO-PLANAR IMAGING; GADOLINIUM DTPA; GLIOMA; HETEROGRAFTS; MAGNETIC RESONANCE IMAGING; RATS; RATS, NUDE;

EID: 84900793115     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.24873     Document Type: Article

References (32)

1. Hylton N,. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J Clin Oncol 2006; 24: 3293-3298.
2. Patlak CS, Blasberg RG, Fenstermacher JD,. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J J Cereb Blood Flow Metab 1983; 3: 1-7.
3. Patlak C, Blasberg R,. Graphical evaluation of blood to brain transfer constants from multiple time up take data. Generalizations. J J Cereb Blood Flow Metab 1985; 5: 584-590.
4. Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging 1999; 10: 223-232.
5. Ewing JR, Brown SL, Lu M, et al. Model selection in magnetic resonance imaging measurements of vascular permeability: Gadomer in a 9L model of rat cerebral tumor. J Cereb Blood Flow Metab 2006; 26: 310-320.
6. Bagher-Ebadian H, Jain R, Nejad-Davarani SP, et al. Model selection for DCE-T1 studies in glioblastoma. Magn Reson Med 2012; 68: 241-251.
7. Logan J, Fowler JS, Volkow ND, et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990; 10: 740-747.
8. Logan J,. Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Biol 2000; 27: 661-670.
9. 14C-sucrose in areas of blood-brain opening. Magn Reson Med 2003; 50: 283-292.
10. Aref M, Chaudhari AR, Bailey KL, Aref S, Wiener EC,. Comparison of tumor histology to dynamic contrast enhanced magnetic resonance imaging-based physiological estimates. Magn Reson Imaging 2008; 26: 1279-1293.
11. Su MY, Cheung YC, Fruehauf JP, et al. Correlation of dynamic contrast enhancement MRI parameters with microvessel density and VEGF for assessment of angiogenesis in breast cancer. J Magn Reson Imaging 2003; 18: 467-477.
12. Ludemann L, Grieger W, Wurm R, Budzisch M, Hamm B, Zimmer C,. Comparison of dynamic contrast-enhanced MRI with WHO tumor grading for gliomas. Eur Radiol 2001; 11: 1231-1241.
13. Kiss R, Dewitte O, Decaestecker C, Camby I, Gordower L, Delbecque K, Pasteels JL, Brotchi J, Salmon I,. The combined determination of proliferative activity and cell density in the prognosis of adult patients with supratentorial high-grade astrocytic tumors. Am J Clin Pathol 1997; 107: 321-331.
14. Cao Y, Shen Z, Chenevert TL, Ewing JR,. Estimate of vascular permeability and cerebral blood volume using Gd-DTPA contrast enhancement and dynamic T 2 * -weighted MRI. J Magn Reson Imaging 2006; 24: 288-296.
15. Kuipers H, Brouwer T, Dubravcic-Simunjak S, Moran J, Mitchel D, Shobe J, Sakai H, Stray-Gundersen J, Vanhoutvin S,. Hemoglobin and hematocrit values after saline infusion and tourniquet. Int J Sports Med 2005; 26: 405-408.
16. Fitzek C, Mentzel HJ, Fitzek S, Sauner D, Kaiser WA, Reichenbach JR,. Echoplanar diffusion-weighted MRI with intravenous gadolinium-DTPA. Neuroradiology 2003; 45: 592-597.
17. Nagaraja TN, Karki K, Ewing JR, Divine GW, Fenstermacher JD, Patlak CS, Knight RA,. The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[(14)C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots. Magn Reson Med 2010; 63: 1502-1509.
18. Bereczki D, Wei L, Otsuka T, Hans F-J, Acuff V, Patlak C, Fenstermacher J,. Hypercapnia slightly raises blood volume and sizably elevates flow velocity in brain microvessels. Am J Physiol 1993; 264: H1360-H1369.
19. Yankeelov TE, Luci JJ, Lepage M, Li R, Debusk L, Lin PC, Price RR, Gore JC,. Quantitative pharmacokinetic analysis of DCE-MRI data without an arterial input function: a reference region model. Magn Reson Imaging 2005; 23: 519-529.
20. Tofts P, Kermode A,. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR Imaging. 1. Fundamental concepts. Magn Reson Med 1991; 17: 357-367.
21. Gelman N, Ewing JR, Gorell JM, Spickler EM, Solomon EG,. Interregional variation of longitudinal relaxation rates in human brain at 3.0 T: relation to estimated iron and water contents. Magn Reson Med 2001; 45: 71-79.
22. Ewing JR, Aryal M, Bagher-Ebadian H, Panda S, Karki K, Nagaraja TN, Cabral G, Fenstermacher JoD, Mikkelsen T,. Dynamic contrast enhanced MRI at 7 T in a rat model of cerebral glioma: data analysis and model selection. In Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Australia, 2012. p. 1530.
23. Sykova E, Nicholson C,. Diffusion in brain extracellular space. Physiol Rev 2008; 88: 1277-1340.
24. Jain R, Ellika SK, Scarpace L, Schultz LR, Rock JP, Gutierrez J, Patel SC, Ewing J, Mikkelsen T,. Quantitative estimation of permeability surface-area product in astroglial brain tumors using perfusion CT and correlation with histopathologic grade. AJNR Am J Neuroradiol 2008; 29: 694-700.
25. Pickup S, Chawla S, Poptani H,. Quantitative estimation of dynamic contrast enhanced MRI parameters in rat brain gliomas using a dual surface coil system. Acad Radiol 2009; 16: 341-350.
26. Chenevert TL, Stegman LD, Taylor JM, Robertson PL, Greenberg HS, Rehemtulla A, Ross BD,. Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors. J Natl Cancer Inst 2000; 92: 2029-2036.
27. Farace P, Merigo F, Fiorini S, Nicolato E, Tambalo S, Daducci A, Degrassi A, Sbarbati A, Rubello D, Marzola P,. DCE-MRI using small-molecular and albumin-binding contrast agents in experimental carcinomas with different stromal content. Eur J Radiol 2011; 78: 52-59.
28. Li X, Rooney WD, Springer CS Jr,. A unified magnetic resonance imaging pharmacokinetic theory: intravascular and extracellular contrast reagents. Magn Reson Med 2005; 54: 1351-1359.
29. Landis CS, Li X, Telang FW, Coderre JA, Micca PL, Rooney WD, Latour LL, Vetek G, Palyka I, Springer CS Jr,. Determination of the MRI contrast agent concentration time course in vivo following bolus injection: effect of equilibrium transcytolemmal water exchange. Magn Reson Med 2000; 44: 563-574.
30. Landis CS, Li X, Telang FW, Molina PE, Palyka I, Vetek G, Springer CS,. Equilibrium transcytolemmal water-exchange kinetics in skeletal muscle in vivo. Magn Reson Med 1999; 42: 467-478.
31. Li X, Rooney WD, Varallyay CG, et al. Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination. J Magn Reson 2010; 206: 190-199.
32. Paudyal R, Poptani H, Cai K, Zhou R, Glickson JD,. Impact of transvascular and cellular-interstitial water exchange on dynamic contrast-enhanced magnetic resonance imaging estimates of blood to tissue transfer constant and blood plasma volume. J Magn Reson Imaging 2013; 37: 435-444.