Determination of free Bisphenol A (BPA) concentrations in breast milk of U.S. women using a sensitive LC/MS/MS method

Chemosphere

Volumn 104, Issue , 2014, Pages 237-243

  Zimmers, Stephanie M ^a   Browne, Eva P ^a   O'Keefe, Patrick W ^a   Anderton, Douglas L ^b   Kramer, Lawrence ^c   Reckhow, David A ^c   Arcaro, Kathleen F ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

^c University of Massachusetts   (United States)

Author keywords

BPA; Breast milk; Exposure; SPE

Indexed keywords

ENDOCRINE DISRUPTERS; HEALTH; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHASE SEPARATION; PHENOLS;

BREAST MILK; ENDOCRINE DISRUPTING COMPOUND; EXPOSURE; HUMAN BREAST MILKS; SENSITIVE METHOD; SOLID-PHASE EXTRACTION; STATISTICAL DIFFERENCES; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

DAIRIES;

4,4' ISOPROPYLIDENEDIPHENOL;

CONCENTRATION (COMPOSITION); ENDOCRINE DISRUPTOR; LACTATION; PHENOL; POLLUTION EXPOSURE; SENSITIVITY ANALYSIS; WOMENS HEALTH;

ADULT; AFRICAN AMERICAN; ARTICLE; ARTIFICIAL MILK; BODY MASS; BREAST MILK; CAUCASIAN; CONCENTRATION (PARAMETERS); ENVIRONMENTAL EXPOSURE; FEMALE; HISPANIC; HUMAN; LIFESTYLE; LIMIT OF DETECTION; METABOLISM; RACE DIFFERENCE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UNITED STATES;

UNITED STATES;

BPA; BREAST MILK; EXPOSURE; SPE;

ADULT; BENZHYDRYL COMPOUNDS; CHROMATOGRAPHY, LIQUID; ENDOCRINE DISRUPTORS; ESTROGENS, NON-STEROIDAL; FEMALE; HUMANS; LIMIT OF DETECTION; MILK, HUMAN; PHENOLS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 84900660664     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2013.12.085     Document Type: Article

References (43)

1. Browne E., Punska E., Lenington S., Otis C., Anderton D., Arcaro K. Increased promoter methylation in exfoliated breast epithelial cells in women with a previous breast biopsy. Epigenetics 2011, 6:1425-1435.
2. Cao X., Zhang J., Goodyer C., Hayward S., Cooke G., Curran I.H.A. Bisphenol A in human placental and fetal liver tissues collected from Greater Montreal area (Quebec) during 1998-2008. Chemosphere 2012, 89:505-511.
3. Chang H., Wan Y., Naile J., Zhang X., Wiseman S., Hecker M., Lam M.H.W., Giesy J., Jones P. Simultaneous quantification of multiple classes of phenolic compounds in blood plasma by liquid chromatography-electrospray tandem mass spectrometry. J. Chromatogr. A 2010, 1217:506-513.
4. Chapin R., Adams J., Boekelheide K., Gray L.E., Hayward S., Lees P.S.J., McIntyre B., Portier K., Schnorr T., Selevan S., Vandenbergh J., Woskie S. NTP-CERHR expert panel report on the reproductive and developmental toxicity of Bisphenol A. Birth defects research. Part B. Dev. Reprod. Toxicol. 2008, 83:157-395.
5. Fox S.D., Falk R.T., Veenstra T.D., Issaq H.J. Quantitation of free and total bisphenol A in human urine using liquid chromatography-tandem mass spectrometry. J. Sep. Sci. 2011, 34:1268-1274.
6. Geens T., Aerts D., Berthot C., Bourguignon J., Goeyens L., Lecomte P., Maghuin Rogister G., Pironnet A., Pussemier L., Scippo M., Van Loco J., Covaci A. A review of dietary and non-dietary exposure to Bisphenol-A. Food Chem. Toxicol. 2012.
7. Ginsberg G., Rice D. Does rapid metabolism ensure negligible risk from Bisphenol A?. Environ. Health Perspect. 2009, 117:1639-1643.
8. Gould J.C., Leonard L.S., Maness S.C., Wagner B.L., Conner K., Zacharewski T., Safe S., McDonnell D.P., Gaido K.W. Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol. Cell. Endocrinol. 1998, 142:203-214.
9. Hanioka N., Naito T., Narimatsu S. Human UDP-glucuronosyltransferase isoforms involved in Bisphenol A glucuronidation. Chemosphere 2008, 74:33-36.
10. Hanioka N., Oka H., Nagaoka K., Ikushiro S., Narimatsu S. Effect of UDP-glucuronosyltransferase 2B15 polymorphism on Bisphenol A glucuronidation. Arch. Toxicol. 2011, 85:1373-1381.
11. Hornung R.W., Reed L.D. Estimation of average concentration in the presence of nondetectable values. Appl. Occup. Environ. Hyg. 1990, 5:46-51.
12. Kang J., Kondo F. Determination of Bisphenol A in milk and dairy products by high-performance liquid chromatography with fluorescence detection. J. Food Prot. 2003, 66:1439-1443.
13. Kuruto-Niwa R., Tateoka Y., Usuki Y., Nozawa R. Measurement of Bisphenol A concentrations in human colostrum. Chemosphere 2007, 66:1160-1164.
14. Lampe J.W., Bigler J., Bush A.C., Potter J.D. Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y). Cancer Epidemiol. Biomarkers Prevent. 2000, 9:329-333.
15. Liao C., Kannan K. Widespread occurrence of Bisphenol A in paper and paper products: implications for human exposure. Environ. Sci. Technol. 2011, 45:9372-9379.
16. Liao C., Kannan K. Determination of free and conjugated forms of Bisphenol A in human urine and serum by liquid chromatography-tandem mass spectrometry. Environ. Sci. Technol. 2012, 46:5003-5009.
17. Long G.W.J.D. Limit of detection A closer look at the IUPAC definition. Anal. Chem. 1983, 55:712A-724A.
18. Markham D., Waechter J., Wimber M., Rao N., Connolly P., Chuang J., Hentges S., Shiotsuka R., Dimond S., Chappelle A. Development of a method for the determination of Bisphenol A at trace concentrations in human blood and urine and elucidation of factors influencing method accuracy and sensitivity. J. Anal. Toxicol. 2010, 34:293-303.
19. Matthews J.B., Twomey K., Zacharewski T.R. In vitro and in vivo interactions of Bisphenol A and its metabolite, Bisphenol A glucuronide, with estrogen receptors alpha and beta. Chem. Res. Toxicol. 2001, 14:149-157.
20. Mendonca K., Hauser R., Calafat A.M., Arbuckle T.E., Duty S.M. Bisphenol A concentrations in maternal breast milk and infant urine. Int. Arch. Occup. Environ. Health. 2014, 87:13-20.
21. Mykkänen H., Tikka J., Pitkänen T., Hänninen O. Fecal bacterial enzyme activities in infants increase with age and adoption of adult-type diet. J. Pediatr. Gastroenterol. Nutr. 1997, 25:312-316.
22. Nagel S.C., vom Saal F.S., Thayer K.A., Dhar M.G., Boechler M., Welshons W.V. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens Bisphenol A and octylphenol. Environ. Health Perspect. 1997, 105:70-76.
23. Otaka H., Yasuhara A., Morita M. Determination of Bisphenol A and 4-nonylphenol in human milk using alkaline digestion and cleanup by solid-phase extraction. Anal. Sci. 2003, 19:1663.
24. Richter C., Birnbaum L., Farabollini F., Newbold R., Rubin B., Talsness C., Vandenbergh J., Walser Kuntz D., vom Saal F. In vivo effects of Bisphenol A in laboratory rodent studies. Reprod. Toxicol. 2007, 24:199-224.
25. Rubin B. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J. Steroid Biochem. Mol. Biol. 2011, 127:27-34.
26. Shankar A., Teppala S., Sabanayagam C. Urinary Bisphenol A levels and measures of obesity: results from the national health and nutrition examination survey 2003-2008. ISRN Endocrinol. 2012, 2012:965243.
27. Sperker B., Backman J.T., Kroemer H.K. The role of beta-glucuronidase in drug disposition and drug targeting in humans. Clin. Pharmacokinet. 1997, 33:18-31.
28. Stahlhut R., Welshons W., Swan S. Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environ. Health Perspect. 2009, 117:784-789.
29. Sun Y., Irie M., Kishikawa N., Wada M., Kuroda N., Nakashima K. Determination of Bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection. Biomed. Chromatogr. 2004, 18:501.
30. Taylor J., Welshons W., Vom Saal F. No effect of route of exposure (oral subcutaneous injection) on plasma Bisphenol A throughout 24h after administration in neonatal female mice. Reprod. Toxicol. 2008, 25:169-176.
31. Trasande L., Attina T., Blustein J. Association between urinary Bisphenol A concentration and obesity prevalence in children and adolescents. JAMA (Chicago, Ill.). 2012, 308:1113-1121.
32. Unal, E.R., Lynn, T., Neidich, J., Salazar, D., Goetzl, L., Baatz, J.E., Hulsey, T.C., Van Dolah, R., Guillette, L.J., Newman, R., 2012. Racial disparity in maternal and fetal-cord Bisphenol A concentrations. J. Perinatol.
33. Vandenberg L., Maffini M., Sonnenschein C., Rubin B., Soto A. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr. Rev. 2009, 30:75-95.
34. Vandenberg L., Chahoud I., Heindel J., Padmanabhan V., Paumgartten F.J.R., Schoenfelder G. Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to Bisphenol A. Environ. Health Perspect. 2010, 118:1055-1070.
35. Völkel W., Colnot T., Csanády G., Filser J., Dekant W. Metabolism and kinetics of Bisphenol A in humans at low doses following oral administration. Chem. Res. Toxicol. 2002, 15:1281-1287.
36. Xu, L., 2007. Mass Spectromic Analysis of Environmentally Relevant Phenolic Compounds.
37. Xu L., Spink D. Analysis of steroidal estrogens as pyridine-3-sulfonyl derivatives by liquid chromatography electrospray tandem mass spectrometry. Anal. Biochem. 2008, 375:105-114.
38. Xu X., Roman J., Issaq H., Keefer L., Veenstra T., Ziegler R. Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. Anal. Chem. 2007, 79:7813-7821.
39. Ye X., Kuklenyik Z., Needham L.L., Calafat A.M. Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry. J. Chromatogr. B. Analyt Technol. Biomed. Life. Sci. 2006, 831:110-115.
40. Ye X., Kuklenyik Z., Needham L., Calafat A. Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry. J. Chromatogr. B 2006, 831:110.
41. Ye X., Bishop A., Needham L., Calafat A. Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. Anal. Chim. Acta 2008, 622:150.
42. Ye X., Zhou X., Hennings R., Kramer J., Calafat A.M. Potential external contamination with Bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge. Environ. Health Perspect. 2013, 121:283-286.
43. Yi, B., Kim, C., Yang, M., 2010. Biological monitoring of Bisphenol A with HLPC/FLD and LC/MS/MS assays. J. Chromatogr. B 878, 2606-2610.