CD16 inhibition increases host survival in a murine model of severe sepsis

Journal of Surgical Research

Volumn 187, Issue 2, 2014, Pages 605-609

  Zhang, Dewen ^a   He, Jian ^a   Shen, Meihua ^a   Wang, Rui ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Animal model; CD16 32 monoclonal antibody; Cytokine; Flow cytometry; High grade sepsis; IL 1 ; Monocyte; TNF

Indexed keywords

CD16 ANTIGEN; INTERLEUKIN 1BETA; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FLOW CYTOMETRY; HOST; MONOCYTE; MOUSE; NONHUMAN; PERITONEUM LAVAGE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPSIS; SEVERE SEPSIS;

ANIMAL MODEL; CD16/32 MONOCLONAL ANTIBODY; CYTOKINE; FLOW CYTOMETRY; HIGH-GRADE SEPSIS; IL-1Β; MONOCYTE; TNF-Α;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD14; CECUM; DISEASE MODELS, ANIMAL; INJECTIONS, INTRAPERITONEAL; KAPLAN-MEIER ESTIMATE; LIGATION; MICE; MONOCYTES; PERITONITIS; RECEPTORS, IGG; SEPSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84900563230     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.11.004     Document Type: Article

References (22)

1. S. Finfer, R. Bellomo, J. Lipman, C. French, G. Dobb, and J. Myburqh Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units Intensive Care Med 30 2004 589
2. C. Brun-Buisson, F. Doyon, and J. Carlet et al. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units JAMA 274 1995 968
3. J. Cohen The immunopathogenesis of sepsis Nature 420 2002 885
4. C. Schinkel, R. Sendtner, S. Zimmer, and E. Faist Functional analysis of monocyte subsets in surgical sepsis J Trauma 44 1998 743
5. P. Ancuta, K.Y. Liu, and V. Misra et al. Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets BMC Genomics 27 2009 403
6. F. Pinheiro da Silva, M. Aloulou, M. Benhamou, and R.C. Monteiro Inhibitory ITAMs: a matter of life and death Trends Immunol 29 2008 366
7. J. Skrzeczyñska, K. Kobylarz, Z. Hartwich, M. Zembala, and J. Pryjma CD14+ CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies Scand J Immunol 55 2002 629
8. F. Pinheiro da Silva, M. Aloulou, and D. Skurnik et al. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation Nat Med 13 2007 1368
9. W.L. Hazenbos, J.E. Gessner, and F.M. Hofhuis et al. Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice Immunity 5 1996 181
10. D. Rittirsch, M.S. Huber-Lang, M.A. Flierl, and P.A. Ward Immunodesign of experimental sepsis by cecal ligation and puncture Nat Protoc 4 2009 31
11. M. Daeron, and R. Lesourne Negative signaling in Fc receptor complexes Adv Immunol 89 2006 39
12. D.L. Williams, C. Li, and T. Ha et al. Modulation of the phosphoinositide 3-kinase pathway alters innate resistance to polymicrobial sepsis J Immunol 172 2004 449
13. P. Villa, G. Sartor, and M. Angelini et al. Pattern of cytokines and pharmacomodulation in sepsis induced by cecal ligation and puncture compared with that induced by endotoxin Clin Diagn Lab Immunol 2 1995 549
14. H. Vamus The new era in cancer research Science 313 2006 1162
15. P. Vassalli The pathophysiology of tumor necrosis factors Annu Rev Immunol 10 1992 411
16. A. Waage, A. Halstensen, and T. Espevik Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease Lancet 1 1987 355
17. M. Guha, and N. Mackman The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells J Biol Chem 277 2002 32124
18. D.F. Barber, A. Bartolomé, and C. Hernandez et al. PI3K gamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus Nat Med 11 2005 933
19. S. Endo, K. Inada, and Y. Inoue et al. Two types of septic shock classified by the plasma level of cytokines and endotoxin Cir Shock 38L 1992 264
20. A.S. Goldie, K.C. Fearon, and J.A. Ross et al. Natural cytokine antagonist and endogenous antiendotoxin core antibodies in sepsis syndrome. The Sepsis Intervention Group J Am Med Assoc 274 1995 172
21. J.E. Salmon, S. Kapur, and R.P. Kimberly Opsonin-independent ligation of Fc gamma receptors. The 3G8-bearing receptors on neutrophils mediate the phagocytosis of concanavalin A-treated erythrocytes and nonopsonized Escherichia coli J Exp Med 166 1987 1798
22. J. Celli, M. Olivier, and B.B. Finlay Enteropathogenic Escherichia coli mediates antiphagocytosis through the inhibition of PI 3-kinase-dependent pathways EMBO J 20 2001 1245