Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans

European Journal of Pharmaceutical Sciences

Volumn 59, Issue 1, 2014, Pages 94-103

  Maeda, Kazuya ^a   Tian, Ying ^a   Fujita, Tomoe ^b   Ikeda, Yasuhiko ^b   Kumagai, Yuji ^b   Kondo, Tsunenori ^c   Tanabe, Kazunari ^c   Nakayama, Hideki ^c   Horita, Shigeru ^c   Kusuhara, Hiroyuki ^a   Sugiyama, Yuichi ^d  

^a UNIVERSITY OF TOKYO   (Japan)

^b KITASATO UNIVERSITY HOSPITAL   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d RIKEN   (Japan)

Author keywords

Adefovir; Benzylpenicillin; Organic anion transporter (OAT); Probe drug; Renal clearance

Indexed keywords

4 AMINOHIPPURIC ACID; ADEFOVIR DIPIVOXIL; BENZATHINE PENICILLIN; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PENICILLIN G; PROBENECID; ADEFOVIR; ADENINE; ORGANIC ANION TRANSPORTER; PHOSPHONIC ACID DERIVATIVE;

AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG URINE LEVEL; GLOMERULUS FILTRATION RATE; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; KIDNEY CLEARANCE; KIDNEY PLASMA FLOW; KIDNEY SLICE; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; ADULT; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BLOOD; CONTROLLED STUDY; DRUG EFFECTS; DRUG INTERACTION; KIDNEY; MALE; METABOLISM; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADENINE; ADULT; DRUG INTERACTIONS; HEK293 CELLS; HUMANS; IN VITRO TECHNIQUES; KIDNEY; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANOPHOSPHONATES; P-AMINOHIPPURIC ACID; PENICILLIN G; PROBENECID; YOUNG ADULT;

EID: 84900557627     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.04.004     Document Type: Article

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