Mechanisms of paracrine cardioprotection by cord blood mesenchymal stromal cells

European Journal of Cardio-thoracic Surgery

Volumn 45, Issue 6, 2014, Pages 983-992

  Bader, Andreas Matthaeus ^a   Brodarac, Andreja ^a   Klose, Kristin ^a   Bieback, Karen ^b   Choi, Yeong Hoon ^c   Kurtz, Andreas ^a   Stamm, Christof ^a,d  

^a Berlin Brandenburg Center for Regenerative Therapies   (Germany)

^b Institute of Transfusion Medicine and Immunology   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Cardiomyocyte; Cell therapy; Cord blood; Ischaemia; Stem cell

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; STAT3 PROTEIN; CULTURE MEDIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; FIBROBLAST; HEART MUSCLE CELL; HEART PROTECTION; IN VITRO STUDY; INTRACELLULAR SIGNALING; ISCHEMIA; MESENCHYMAL STROMA CELL; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; UMBILICAL CORD BLOOD; WESTERN BLOTTING; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL SURVIVAL; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECTS; FETUS BLOOD; HEART MUSCLE ISCHEMIA; METABOLISM; MOUSE; PHARMACOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; FETAL BLOOD; MAP KINASE SIGNALING SYSTEM; MESENCHYMAL STROMAL CELLS; MICE; MODELS, CARDIOVASCULAR; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84900541575     PISSN: 10107940     EISSN: 1873734X     Source Type: Journal    
DOI: 10.1093/ejcts/ezt576     Document Type: Article

References (25)

1. Mirotsou M, Jayawardena TM, Schmeckpeper J, Gnecchi M, Dzau VJ. Paracrine mechanisms of stem cell reparative and regenerative actions in the heart. J Mol Cell Cardiol 2011;50:280-9.
2. Korf-Klingebiel M, Kempf T, Sauer T, Brinkmann E, Fischer P, Meyer GP et al. Bone marrow cells are a rich source of growth factors and cytokines: implications for cell therapy trials after myocardial infarction. Eur Heart J 2008;29:2851-8.
3. Yasin M. Removing the cells from adult bone marrow derived stem cell therapy does not eliminate cardioprotection. Eur J Cardiothorac Surg 2013;43:840-8.
4. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009;54:2277-86.
5. Herrmann JL, Wang Y, Abarbanell AM, Weil BR, Tan J, Meldrum DR. Preconditioning mesenchymal stem cells with transforming growth factor-alpha improves mesenchymal stem cell-mediated cardioprotection. Shock 2010;33:24-30.
6. Gaebel R, Furlani D, Sorg H, Polchow B, Frank J, Bieback K et al. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration. PLoS One 2011;6:e15652.
7. Xu M, Uemura R, Dai Y, Wang Y, Pasha Z, Ashraf M. In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol 2007;42:441-8.
8. Kern S, Eichler H, Stoeve J, Kluter H, Bieback K. Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 2006;24:1294-301.
9. Klose K, Roy R, Brodarac A, Kurtz A, Ode A, Kang KS et al. Impact of heart failure on the behavior of human neonatal stem cells in vitro. J Transl Med 2013;11:236.
10. Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C et al. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 2004;364:141-8.
11. Assmus B, Schachinger V, Teupe C, Britten M, Lehmann R, Dobert N et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 2002;106: 3009-17.
12. Lai VK, Ang KL, Rathbone W, Harvey NJ, Galinanes M. Randomized controlled trial on the cardioprotective effect of bone marrow cells in patients undergoing coronary bypass graft surgery. Eur Heart J 2009;30: 2354-9.
13. Boomsma RA, Geenen DL. Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis. PLoS One 2012;7:e35685.
14. Benzhi C, Limei Z, Ning W, Jiaqi L, Songling Z, Fanyu M et al. Bone marrow mesenchymal stem cells upregulate transient outward potassium currents in postnatal rat ventricular myocytes. J Mol Cell Cardiol 2009;47: 41-8.
15. Lai VK, Linares-Palomino J, Nadal-Ginard B, Galinanes M. Bone marrow cell-induced protection of the human myocardium: characterization and mechanism of action. J Thorac Cardiovasc Surg 2009;138:1400-8, e1401.
16. Claycomb WC, Lanson NA Jr, Stallworth BS, Egeland DB, Delcarpio JB, Bahinski A et al. HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte. Proc Natl Acad Sci USA 1998;95:2979-84.
17. Li H, Malhotra D, Yeh CC, Tu R, Zhu BQ, Birger N et al. Myocardial survival signaling in response to stem cell transplantation. J Am Coll Surg 2009; 208:607-13.
18. Andersen AD, Bentzen BH, Salling H, Klingberg H, Kanneworff M, Grunnet M et al. The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na(+)/H(+) exchanger NHE1. Cell Physiol Biochem 2011;28:13-24.
19. Beharier O, Dror S, Levy S, Kahn J, Mor M, Etzion S et al. ZnT-1 protects HL-1 cells from simulated ischemia-reperfusion through activation of Ras-ERK signaling. J Mol Med (Berl) 2012;90:127-38.
20. Hausenloy DJ, Mocanu MM, Yellon DM. Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning. Cardiovasc Res 2004;63:305-12.
21. Suleman N, Somers S, Smith R, Opie LH, Lecour SC. Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning. Cardiovasc Res 2008;79:127-33.
22. McCormick J, Barry SP, Sivarajah A, Stefanutti G, Townsend PA, Lawrence KM et al. Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury. FASEB J 2006;20:2115-7.
23. Arany I, Megyesi JK, Nelkin BD, Safirstein RL. STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells. Kidney Int 2006;70:669-74.
24. Przybyt E, Krenning G, Brinker MG, Harmsen MC. Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2. J Transl Med 2013; 11:39.
25. Nakazato K, Naganuma W, Ogawa K, Yaoita H, Mizuno S, Nakamura T et al. Attenuation of ischemic myocardial injury and dysfunction by cardiac fibroblast-derived factor(s). Fukushima J Med Sci 2010;56: 1-16.