Neurobehavioral effects of aspartame consumption

Research in Nursing and Health

Volumn 37, Issue 3, 2014, Pages 185-193

  Lindseth, Glenda N ^a   Coolahan, Sonya E ^b   Petros, Thomas V ^a   Lindseth, Paul D ^a  

^a UNIVERSITY OF NORTH DAKOTA   (United States)

^b RAPID CITY REGIONAL HOSPITAL   (United States)

Author keywords

Aspartame; Cognition; Depression; Food additive; Memory; Neurobehavioral effect; Spatial orientation; Sweetener

Indexed keywords

ASPARTAME; FOOD ADDITIVE; SWEETENING AGENT;

ADULT; ANTHROPOMETRY; ARTICLE; CHEMICALLY INDUCED DISORDER; COGNITION; COGNITIVE DEFECT; DEPRESSION; FEMALE; HEADACHE; HUMAN; MALE; MEMORY; MOOD DISORDER; NEUROBEHAVIORAL EFFECT; NEUROPSYCHOLOGICAL TEST; QUESTIONNAIRE; SPATIAL ORIENTATION;

ASPARTAME; COGNITION; DEPRESSION; FOOD ADDITIVE; MEMORY; NEUROBEHAVIORAL EFFECT; SPATIAL ORIENTATION; SWEETENER;

ADULT; ANTHROPOMETRY; ASPARTAME; COGNITION DISORDERS; DEPRESSION; FEMALE; HEADACHE; HUMANS; MALE; MOOD DISORDERS; NEUROPSYCHOLOGICAL TESTS; QUESTIONNAIRES; SWEETENING AGENTS;

EID: 84900530428     PISSN: 01606891     EISSN: 1098240X     Source Type: Journal    
DOI: 10.1002/nur.21595     Document Type: Article

References (56)

1. Baddeley, A. D. (1996). Exploring the central executive. Quarterly Journal of Experimental Psychology, 49, 5-28. doi: 10.1080/713755608
2. Baddeley, A.D., & Hitch, G. (1974). Working memory. In G. H. Bower (Ed.) The psychology of learning and motivation: Advances in research and theory. (pp. 47-89). New York, NY: Academic Press. doi: 10.1016/S0079-7421(08)60452-1
3. Biggs, J. T., Wylie, L. T., & Ziegler, V. E. (1978). Validity of the Zung Self-Rating Depression Scale. The British Journal of Psychiatry: The Journal of Mental Science, 132, 381-385. doi: 10.1192/bjp.132.4.381
4. Borenstein, M., Rothstein, H., & Cohen, J. (2001). Power and precision: A computer program for statistical power analysis and confidence intervals (Version 4) [Computer software]. Englewood Cliffs, NJ: Biostat, Inc.
5. Brandt, K. R., Sunram-Lea, S. I., & Qualtrough, K. (2006). The effect of glucose administration on the emotional enhancement effect in recognition memory. Biological Psychology, 73, 199-208. doi: 10.1016/j.biopsycho.2006.04.001
6. Butchko, H. H., & Stargel, W. W. (2001). Aspartame: Scientific evaluation in the post marketing period. Regulatory Toxicology and Pharmacology, 34, 221-233. doi: 10.1006/rtph.2001.1500
7. Butchko, H. H., Stargel, W. W., Comer, C. P., Mayhew, D. A., Benninger, C., Blackburn, G. L & Trefz, F. K. (2002). Aspartame: Review of safety. Regulatory Toxicity and Pharmacology, 35, S1-S93. doi: 10.1006/rtph.2002.1542
8. Caballero, B., & Wurtman, R. J. (1988). Control of plasma phenylalanine levels. In R. J. Wurtman & E. Ritterwalker, (Eds.) Dietary phenylalanine and brain function. (2013 reprint, pp. 3-12). Birkhauser Boston. doi: 10.1007/978-1-4615-9821-3_1
9. Campbell, M. H., Maynard, D., Roberti, J. W., & Emmanuel, M. K. (2012). A comparison of the psychometric strengths of the public-domain Zung self-rating depression scale with the proprietary Beck Depression Inventory-II in Barbados. West Indian Medical Journal, 61, 483-488.
10. Cohen, J. (1988). Statistical power analysis for the behavioral sciences. (2nd ed.). Hillsdale, NJ: Erlbaum Associates.
11. Doenges, M. E., Geissler, A. C., & Moorhouse, M. F. (1989). Nursing care plans: Guidelines for individualizing patient care. Philadelphia, PA: F.A. Davis.
12. Ekong, M. B. (2009). Aspartame: Sweet or bitter. Internet Journal of Health, 9, 2. doi: 10.5580/139b
13. ESHA Research. (2010). The food processor nutrition analysis software (Version 10.8) [Computer Software]. Salem, OR: ESHA Research. Retrieved from http://www.esha.com/foodprosql
14. Fernstrom, J. D. (2009). Aspartame effects on the brain. [Letter to the Editor.] European Journal of Clinical Nutrition, 63, 698-699. doi: 10.1038/ejcn.2008.5
15. Food and Nutrition Board. (1998). Recommended dietary allowances. Washington, DC: The National Academies Press.
16. Gendle, M. H., Smucker, D. M., Stafstrom, J. A., Helterbran, M. C., & Glazer, K. S. (2009). Attention and reaction time in university students following the consumption of Red Bull. The Open Nutrition Journal, 3, 8-10. doi: 10.2174/1874288200903010008
17. Gibson, R. (1990). Principles of nutrition assessment. New York, NY: Oxford University Press.
18. Gordon, H. W., & Leighty, R. (1988). Importance of specialized cognitive function in the selection of military pilots. Journal of Applied Psychology, 73, 38-45.
19. Harte, C. B., & Kanarek, R. B. (2004). The effects of nicotine and sucrose on spatial memory and attention. Nutritional Neuroscience, 7, 121-125. doi: 10.1080/1028415041000170.4543
20. Humphries, P., Pretorius, E., & Naudé, H. (2008). Direct and indirect cellular effects of aspartame on the brain. European Journal of Clinical Nutrition, 62, 451-462. doi: 10.1038/sj.ejcn.1602866
21. Jacob, S. E., & Stechschulte, S., (2008). Formaldehyde, aspartame, and migraines: A possible connection. Dermatitis: Contact, Atopic, Occupational, Drug, 19, E10-E11. Retrieved from http://while-science-sleeps.com/pdf/328.pdf
22. Jonides, J., & Nee, D. E. (2006). Brain mechanisms of proactive interference in working memory. Neuroscience, 139, 181-193. doi:
23. Kazdin, A. E. (2002). Research design in clinical psychology. (4th ed.) Needham Heights, MA: Allyn & Bacon.
24. Konen, J. A., Sia, T. L., Czuchry, M., Stuntz, P. M., Bahr, G. S., Barth, T. M., Dansereau, D. F. (2000, November). Perceived memory impairment in aspartame users. Presented at the Society for Neuroscience 30th Annual Meeting, New Orleans, LA.
25. Lean, M. E., & Hankey, C. R. (2004). Aspartame and its effects on health. British Medical Journal (Clinical Research Ed.), 329, 755-756. doi: 10.1136/bmj.329.7469.755
26. Lindseth, G., Lindseth, P., Jensen, W., Petros, T., Helland, B., & Fossum, D. (2011). Dietary effects on cognition and pilots' flight performance. International Journal of Aviation Psychology, 21, 269-282.
27. Lindseth, P., Lindseth, G., Petros, T., Jensen, W., & Caspers, J. (2013). Effects of hydration on cognitive function of pilots. Military Medicine, 178, 792-798.
28. Lupien, S., Gillin, C., & Hauger, R. (1999). Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: A dose-response study in humans. Behavioral Neuroscience, 113, 420-430. doi: 10.1037/0735-7044.113.3.420
29. Magnuson, B. (2010). Aspartame-Facts and fiction. Journal of the New Zealand Medical Association, 123(1311), 53-57.
30. Marks, G. C., Habicht, J. P., & Mueller, W. H. (1989). Reliability, dependability, and precision of anthropometric measurements: The second national health and nutrition examination. American Journal of Epidemiology, 130, 578-587.
31. Millichap, J. G., & Yee, M. M. (2003). The diet factor in pediatric and adolescent migraine. Pediatric Neurology, 28, 9-15. doi: 10.1016/S0887-8994(02)00466-6
32. Mortelmans, L. J. M., Van Loo, M., De Cauwer, H. G., & Merlevede, K. (2008). Seizures and hyponatremia after excessive intake of Diet Coke. European Journal of Emergency Medicine, 15, 51, doi: 10.1097/MEJ.0b013e3282703645
33. Passik, S. D., Lundberg, J. C., Rosenfeld, B., Kirsh, K. L., Donaghy, K., Theobald, D., & Dugan, W. (2000). Factor analysis of the Zung Self-Rating Depression Scale a large ambulatory oncology sample. Psychosomatics, 41, 121-127. doi: 10.1176/appi.psy.41.2.121
34. Reid, M., Hammersley, R., & Duffy, M. (2010). Effects of sucrose drinks on macronutrient intake, body weight, and mood state in overweight women over 4 weeks. Appetite, 55, 130-136. doi: 10.1016/j.appet.2010.05.001
35. Reid, M., Hammersley, R., Hill, A. J., & Skidmore, P. (2007). Long-term dietary compensation for added sugar: Effects of supplementary sucrose drinks over a 4-week period. The British Journal of Nutrition, 97, 193-203. doi: 10.1017/S0007114507252705
36. Rycerz, K., & Jaworska-Adamu, J. E. (2013). Effects of aspartame metabolites on astrocytes and neurons. Folia Neuropathologica/Association of Polish Neuropathologists and Medical Research Centre. Polish Academy of Sciences, 51, 10-17.
37. Sakamoto, S., Kambara, M., & Tanno, Y. (2001). Response styles and cognitive and affective symptoms of depression. Personality and Individual Differences, 31, 1053-1065.
38. Stegink, L. D., & Filer, L. J Jr., (1996). Effects of aspartame ingestion on plasma aspartate, phenylalanine, and methanol concentrations in normal adults. In C. Tschanz, H. H. Butchko, W. W. Stargel, & F. N. Kotsonis (Eds.). The clinical evaluation of a food additive: Assessment of aspartame. (pp. 67-86). Boca Raton, FL: CRC Press.
39. Stegink, L. D., Wolf-Novak, L. C., Filer, L. J Jr., Bell, E. F., Ziegler, E. E., Krause, W. L., & Brummel, M. C. (1987). Aspartame sweetened beverage: Effect on plasma amino acid concentrations in normal adults and adults heterozygous for phenylketonuria. Journal of Nutrition, 117, 1989-1995.
40. Sternberg, S. (1966) High-speed scanning in human memory. Science, 153, 652-654. doi: 10.1126/science.153.3736.652
41. Sun-Edelstein, C., & Mauskop, A. (2009). Foods and supplements in the management of migraine headaches. The Clinical Journal of Pain, 25, 446-452. doi: 10.1097/AJP.0b013e31819a6f65
42. Sunram-Lea, S., Foster, J., Durlach, P., & Perez, C. (2002). Investigation into the significance of task difficulty and divided allocation of resources on the glucose memory facilitation effect. Psychopharmacology, 160, 387-397. doi: 10.1007/s00213-001-0987-9
43. Thomas, P. (2005). Aspartame: The shocking story of the world's best selling sweetener. The Ecologist, 1, 36-46.
44. US Food and Drug Administration (FDA). (1981). Aspartame: Commissioner's final decision. Federal Register, 46, 38285-38308.
45. US Food and Drug Administration (FDA). (2006). Artificial sweeteners: No calories sweet! FDA Consumer Magazine, 40, 27-28.
46. Van den Eeden, S. K., Koepsell, T. D., Longstreth, W. T., van Belle, G., Daling, J. R., & McKnight, B. (1994). Aspartame ingestion and headaches: A randomized crossover trial. Neurology, 44, 1787-1793. doi: 10.1212/WNL.44.10.1787
47. Vandenberg, S. G., & Kuse, A. R. (1978). Mental rotations, a group test of three-dimensional spatial visualization. Perceptual and Motor Skills, 47, 599-604. doi: 10.2466/pms.1978.47.2.599
48. Voyer, D., Butler, T., Cordero, J., Brake, B., Silbersweig, D., Stern, E., & Imperato-McGinley, J. (2006). The relation between computerized and paper-and-pencil mental rotation tasks: A validation study. Journal of Clinical and Experimental Neuropsychology, 28, 928-939. doi: 10.1080/13803390591004310
49. Walton, R., Hudak, R., & Green-Waite, R. (1993). Adverse reactions to aspartame: Double-blind challenge in patients from a vulnerable population. Biological Psychiatry, 34, 13-17. doi: 10.1016/0006-3223(93)90251-8
50. Whitehouse, C. R., Boullata, J., & McCauley, L. A. (2008). The potential toxicity of artificial sweeteners. American Association of Occupational Health Nurses Journal, 56, 251-259. doi: 10.3928/08910162-20080601-02
51. World Health Organization. (2004). Harmonization project document no. 1 IPCS risk assessment terminology: Definition of key terms. (pp. 10-15). Geneva: Author.
52. Wurtman, R. J. (1983). Neurochemical changes following high-dose aspartame with dietary carbohydrates. The New England Journal of Medicine, 309, 429-430. doi: 10.1056/NEJM198308183090710
53. Wurtman, R. J. (1987). Aspartame effects on brain serotonin. American Journal of Clinical Nutrition, 45, 799-803.
54. Zung, W. W. (1965). A self-rating scale for depression. Archives of General Psychiatry, 12, 63-70. doi: 10.1001/archpsyc.1965.01720310065008
55. Zung, W. W. (1986). Zung Self-Rating Depression Scale and Depression Status Inventory. In T. A. Ban & N. Sartorius (Eds.), Assessment of depression. (pp. 221-231). New York, NY: Springer Verlag. doi: 10.1007/978-3-642-70486-4_21
56. Zung, W. W., Richards, C. B., & Short, M. J. (1965). Self-Rating Depression Scale in an outpatient clinic. Further validation of the SDS. Archives of General Psychiatry, 13, 508-515.