Human PLCζ exhibits superior fertilization potency over mouse PLCζ in triggering the Ca2+ oscillations required for mammalian oocyte activation

Molecular Human Reproduction

Volumn 20, Issue 6, 2014, Pages 489-498

  Nomikos, Michail ^a   Theodoridou, Maria ^a,b   Elgmati, Khalil ^a   Parthimos, Dimitris ^a   Calver, Brian L ^a   Buntwal, Luke ^a   Nounesis, George ^b   Swann, Karl ^a   Anthony Lai, F ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

Fertilization; Male infertility; Oocyte activation; Phospholipase C; PLCzeta; Sperm

Indexed keywords

CALCIUM; PHOSPHOLIPASE C; PHOSPHOLIPASE C ZETA; UNCLASSIFIED DRUG; CHIMERIC PROTEIN; LUCIFERASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE PHOSPHODIESTERASE; PLCZ1 PROTEIN, HUMAN; PLCZ1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CHIMERA; CYTOPLASM; FEMALE; FERTILIZATION IN VITRO; HUMAN; MAMMAL; MATHEMATICAL MODEL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; SPECIES DIFFERENCE; SPERM; ADULT; ANIMAL; CYTOLOGY; ESCHERICHIA COLI; FERTILITY; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SPERMATOZOON;

ADULT; ANIMALS; CALCIUM; CALCIUM SIGNALING; ESCHERICHIA COLI; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LUCIFERASES; MALE; MICE; MUTANT CHIMERIC PROTEINS; OOCYTES; PHOSPHOINOSITIDE PHOSPHOLIPASE C; PROTEIN STRUCTURE, TERTIARY; SPECIES SPECIFICITY; SPERM-OVUM INTERACTIONS; SPERMATOZOA;

EID: 84900527603     PISSN: 13609947     EISSN: 14602407     Source Type: Journal    
DOI: 10.1093/molehr/gau011     Document Type: Article

References (31)

1. Bedford-Guaus SJ, McPartlin LA, Xie J, Westmiller SL, Buffone MG, Roberson MS. Molecular cloning and characterization of phospholipase C zeta in equine sperm and testis reveals species-specific differences in expression of catalytically active protein. Biol Reprod 2011;85:78-88.
2. Cooney MA, Malcuit C, Cheon B, Holland MK, Fissore RA, D'Cruz NT. Species-specific differences in the activity and nuclear localization of murine and bovine phospholipase C zeta 1. Biol Reprod 2010;83:92-101.
3. 2+ oscillations, activation and development of mouse oocytes. Reproduction 2002;124:611-623.
4. Heytens E, Parrington J, Coward K, Young C, Lambrecht S, Yoon SY, Fissore RA, Hamer R, Deane CM, Ruas M et al. Reduced amounts and abnormal forms of phospholipase C zeta (PLCζ) in spermatozoa from infertile men. Hum Reprod 2009;24:2417-2428.
5. Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K. Oocyte activation, phospholipaseCzeta and human infertility. HumReprod Update 2010;16:690-703.
6. Kashir J, Jones C, LeeH C, Rietdorf K, Nikiforaki D, Durrans C, Ruas M, Tee ST, Heindryckx B, Galione A et al. Loss of activity mutations in phospholipaseC zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes. Hum Reprod 2011;26:3372-3387.
7. Kashir J, Konstantinidis M, Jones C, Lemmon B, Lee HC, Hamer R, Heindryckx B, Deane CM, De Sutter P, Fissore RA et al. A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility. Hum Reprod 2012;27:222-231.
8. 2+ oscillations in mouse eggs. J Biol Chem 2004;279:10408-10412.
9. 2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs. Science 1992;257:251-255.
10. 2+oscillations at fertilizationofmammalian eggs. DevBiol 1993;158:62-78.
11. Nakano Y, Shirakawa H, Mitsuhashi N, Kuwabara Y, Miyazaki S. Spatiotemporal dynamics of intracellular calcium in the mouse egg injected with a spermatozoon. Mol Hum Reprod 1997;3:1087-1093.
12. 2+ oscillations. J Biol Chem 2005;280:31011-31018.
13. Nomikos M, Mulgrew-Nesbitt A, Pallavi P, Mihalyne G, Zaitseva I, Swann K, Lai FA, Murray D, McLaughlin S. Binding of phosphoinositide-specific phospholipase C-zeta (PLC-zeta) to phospholipid membranes: potential role of an unstructured cluster of basic residues. J Biol Chem 2007;282:16644-16653.
14. 2+ oscillation-inducing and PIP2 hydrolysis activity of sperm PLCzeta. Biochem J 2011a;434:211-217.
15. Nomikos M, Elgmati K, Theodoridou M, Georgilis A, Gonzalez-Garcia JR, Nounesis G, Swann K, Lai FA. Novel regulation of PLCζ activity via its XY-linker. Biochem J 2011b;438:427-432.
16. Nomikos M, Elgmati K, Theodoridou M, Calver BL, Nounesis G, Swann K, Lai FA. Phospholipase Czeta binding to PtdIns(4,5)P2 requires the XY-linker region. J Cell Sci 2011c;124:2582-2590.
17. 2+ signal that induces egg activation and embryo development: an essential phospholipase C with implications for male infertility. Bioessays 2012;34:126-134.
18. Nomikos M, Yu Y, Elgmati K, Theodoridou M, Campbell K, Vassilakopoulou V, Zikos C, Livaniou E, Amso N, Nounesis G et al. Phospholipase Cz rescues failed oocyte activation in a prototype of male factor infertility. Fertil Steril 2013;99:76-85.
19. Parthimos D, Haddock RE, Hill CE, Griffith TM. Dynamics of a three-variable nonlinear model of vasomotion: comparison of theory and experiment. Biophys J 2007;93:1534-1556.
20. 2+ oscillators. Am J Physiol 2009;277:H1119-H1144.
21. 2+ oscillations in eggs and embryo development. Development 2002;129:3533-3544.
22. Saunders CM, Swann K, Lai FA. PLCzeta, a sperm-specific PLC and its potential role in fertilization. Biochem Soc Symp 2007;74:23-36.
23. 2+ oscillations in fertilizing mammalian eggs. Cell Calcium 2013;53:55-62.
24. 2+oscillations and egg activation in mammals. Semin Cell Dev Biol 2006;17:264-273.
25. Swann K, Campbell K, Yu Y, Saunders C, Lai FA. Use of luciferase chimaera to monitor PLCzeta expression in mouse eggs. Methods Mol Biol 2009;518:17-29.
26. Tesarik J, Sousa M, Testart J. Human oocyte activation after intracytoplasmic sperm injection. Hum Reprod 1994;9:511-518.
27. 2+ oscillations in mammalian eggs at fertilization. Mol Hum Reprod 2013;19:852-864.
28. Vanden Meerschaut F, Leybaert L, Nikiforaki D, Qian C, Heindryckx B, De Sutter P. Diagnostic and prognostic value of calcium oscillatory pattern analysis for patientswith ICSI fertilization failure. HumReprod 2013;28:87-98.
29. 2+ oscillation-inducing abilities of mouse and human dead (sonicated) spermatozoa. Zygote 2009;17:175-184.
30. 2+ release and are unable to initiate the first step of embryo development. J Clin Invest 2008;118:3671-3681.
31. Yoon SY, Eum JH, Lee JE, Lee HC, Kim YS, Han JE, Won HJ, Park SH, Shim SH, Lee WS et al. Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes. Hum Reprod 2012;27:1768-1780.