Naïve subset develops the most important alloreactive response among human CD4+ T lymphocytes in Human Leukocyte Antigen-identical related setting

European Journal of Haematology

Volumn 92, Issue 6, 2014, Pages 491-496

  Chérel, Mathilde ^a,b   Choufi, Bachra ^a,c   Trauet, Jacques ^a,b   Cracco, Pascale ^b   Dessaint, Jean Paul ^a,b   Yakoub Agha, Ibrahim ^a,b   Labalette, Myriam ^a,b  

^a UNIV LILLE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c Service d'Hématologie CH Boulogne Sur Mer   (France)

Author keywords

Allogeneic stem cell transplantation; Alloreactivity; Graft versus host disease; Human leukocyte antigen identical sibling; Na ve T cells

Indexed keywords

CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; INTERLEUKIN 6; LEUKOCYTE ANTIGEN; MINOR HISTOCOMPATIBILITY ANTIGEN; TUMOR NECROSIS FACTOR; AUTACOID; CYTOKINE; HLA ANTIGEN; MEMBRANE ANTIGEN;

ALLOIMMUNITY; ARTICLE; CD4+ CCR7+ CD45RA+ T CELL; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FEMALE; GRAFT VERSUS HOST REACTION; HLA SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ALLELE; BIOSYNTHESIS; CELL CULTURE; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; SIBLING;

ALLELES; ANTIGENS, SURFACE; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; HLA ANTIGENS; HUMANS; IMMUNOLOGIC MEMORY; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; SIBLINGS; T-LYMPHOCYTE SUBSETS;

EID: 84900508837     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/ejh.12283     Document Type: Article

References (28)

1. Hambach L, Spierings E, Goulmy E. Risk assessment in haematopoietic stem cell transplantation: minor histocompatibility antigens. Best Pract Res Clin Haematol 2007;20:171-87.
2. Spierings E, Kim YH, Hendriks M, et al. Multicenter analyses demonstrate significant clinical effects of minor histocompatibility antigens on GvHD and GvL after HLA-matched related and unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2013;19:1244-53.
3. Chakraverty R, Sykes M. The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood 2007;110:9-17.
4. Beilhack A, Schulz S, Baker J, et al. Prevention of acute graft-versus-host disease by blocking T-cell entry to secondary lymphoid organs. Blood 2008;111:2919-28.
5. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999;401:708-12.
6. Anderson BE, McNiff J, Yan J, Doyle H, Mamula M, Shlomchik MJ, Shlomchik WD. Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest 2003;112:101-8.
7. Chen BJ, Cui X, Sempowski GD, Liu C, Chao NJ. Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood 2004;103:1534-41.
8. Zheng H, Matte-Martone C, Li H, Anderson BE, Venketesan S, Sheng Tan H, Jain D, McNiff J, Shlomchik WD. Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood 2008;111:2476-84.
9. Coghill JM, Carlson MJ, Panoskaltsis-Mortari A, West ML, Burgents JE, Blazar BR, Serody JS. Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells. Blood 2010;115:4914-22.
10. Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 2008;111:5242-51.
11. Yakoub-Agha I, Saule P, Depil S, Micol JB, Grutzmacher C, Boulanger-Villard F, Bauters F, Jouet JP, Dessaint JP, Labalette M. A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy. Leukemia 2006;20:1557-65.
12. Chang YJ, Zhao XY, Huo MR, Huang XJ. Expression of CD62L on donor CD4(+) T cells in allografts: correlation with graft-versus-host disease after unmanipulated allogeneic blood and marrow transplantation. J Clin Immunol 2009;29:696-704.
13. Spierings E, Vermeulen CJ, Vogt MH, Doerner LE, Falkenburg JH, Mutis T, Goulmy E. Identification of HLA class II-restricted H-Y-specific T-helper epitope evoking CD4 + T-helper cells in H-Y-mismatched transplantation. Lancet 2003;362:610-5.
14. Zorn E, Miklos DB, Floyd BH, Mattes-Ritz A, Guo L, Soiffer RJ, Antin JH, Ritz J. Minor histocompatibility antigen DBY elicits a coordinated B and T cell response after allogeneic stem cell transplantation. J Exp Med 2004;199:1133-42.
15. Vogt MH, van den Muijsenberg JW, Goulmy E, Spierings E, Kluck P, Kester MG, van Soest RA, Drijfhout JW, Willemze R, Falkenburg JH. The DBY gene codes for an HLA-DQ5-restricted human male-specific minor histocompatibility antigen involved in graft-versus-host disease. Blood 2002;99:3027-32.
16. Foster AE, Marangolo M, Sartor MM, Alexander SI, Hu M, Bradstock KF, Gottlieb DJ. Human CD62L- memory T cells are less responsive to alloantigen stimulation than CD62L+ naive T cells: potential for adoptive immunotherapy and allodepletion. Blood 2004;104:2403-9.
17. Stumpf AN, van der Meijden ED, van Bergen CA, Willemze R, Falkenburg JH, Griffioen M. Identification of 4 new HLA-DR-restricted minor histocompatibility antigens as hematopoietic targets in antitumor immunity. Blood 2009;114:3684-92.
18. Randolph SS, Gooley TA, Warren EH, Appelbaum FR, Riddell SR. Female donors contribute to a selective graft-versus-leukemia effect in male recipients of HLA-matched, related hematopoietic stem cell transplants. Blood 2004;103:347-52.
19. Stern M, Brand R, de Witte T, Sureda A, Rocha V, Passweg J, Baldomero H, Niederwieser D, Gratwohl A. Female-versus-male alloreactivity as a model for minor histocompatibility antigens in hematopoietic stem cell transplantation. Am J Transplant 2008;8:2149-57.
20. Loren AW, Bunin GR, Boudreau C, Champlin RE, Cnaan A, Horowitz MM, Loberiza FR, Porter DL. Impact of donor and recipient sex and parity on outcomes of HLA-identical sibling allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2006;12:758-69.
21. Godfrey WR, Krampf MR, Taylor PA, Blazar BR. Ex vivo depletion of alloreactive cells based on CFSE dye dilution, activation antigen selection, and dendritic cell stimulation. Blood 2004;103:1158-65.
22. Martins SL, St John LS, Champlin RE, Wieder ED, McMannis J, Molldrem JJ, Komanduri KV. Functional assessment and specific depletion of alloreactive human T cells using flow cytometry. Blood 2004;104:3429-36.
23. Ravkov EV, Williams MA. The magnitude of CD4+ T cell recall responses is controlled by the duration of the secondary stimulus. J Immunol 2009;183:2382-9.
24. Eljaafari A, Farre A, Duperrier K, Even J, Vie H, Michallet M, Souillet G, Catherine Freidel A, Gebuhrer L, Rigal D. Generation of helper and cytotoxic CD4+ T cell clones specific for the minor histocompatibility antigen H-Y, after in vitro priming of human T cells by HLA-identical monocyte-derived dendritic cells. Transplantation 2001;71:1449-55.
25. Jin Y, Hernandez A, Fuller L, Rosen A, Cirocco R, Esquenazi V, Ciancio G, Burke GW, Miller J. A novel approach to detect donor/recipient immune responses between HLA-identical pairs. Hum Immunol 2007;68:350-61.
26. Lonial S, Torre C, David E, Harris W, Arellano M, Waller EK. Regulation of alloimmune responses by dendritic cell subsets. Exp Hematol 2008;36:1309-17.
27. Macedo C, Orkis EA, Popescu I, Elinoff BD, Zeevi A, Shapiro R, Lakkis FG, Metes D. Contribution of naive and memory T-cell populations to the human alloimmune response. Am J Transplant 2009;9:2057-66.
28. Litjens NH, van de Wetering J, van Besouw NM, Betjes MG. The human alloreactive CD4+ T-cell repertoire is biased to a Th17 response and the frequency is inversely related to the number of HLA class II mismatches. Blood 2009;114:3947-55.