Necessary, but not sufficient: Insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures

Neuropharmacology

Volumn 84, Issue , 2014, Pages 1-12

  Bernard, Paul B ^a   Castano, Anna M ^a   Bayer, K Ulrich ^b   Benke, Tim A ^a,b  

^a University of Colorado Denver and Children s Hospital Colorado   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Autism; CaMKII; Early life seizure; Long term depression; Metabotropic glutamate receptor; Voltage gated calcium channels

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CHANNEL L TYPE; MAMMALIAN TARGET OF RAPAMYCIN; METABOTROPIC RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEASOME; S6 KINASE; KAINIC ACID; MTOR PROTEIN, RAT; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CELL FRACTIONATION; CONTROLLED STUDY; DOWN REGULATION; EARLY LIFE SEIZURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; LONG TERM DEPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEIZURE; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; MEMBRANE POTENTIAL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SYNAPSE; TISSUE CULTURE TECHNIQUE;

ANIMALS; CALCIUM CHANNELS, L-TYPE; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HIPPOCAMPUS; KAINIC ACID; LONG-TERM SYNAPTIC DEPRESSION; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIALS; PROTEASOME ENDOPEPTIDASE COMPLEX; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RIBOSOMAL PROTEIN S6 KINASES; SEIZURES; SIGNAL TRANSDUCTION; SYNAPSES; TISSUE CULTURE TECHNIQUES; TOR SERINE-THREONINE KINASES;

EID: 84900502887     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.04.011     Document Type: Article

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