U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21

Molecular Neurodegeneration

Volumn 9, Issue 1, 2014, Pages

  Hales, Chadwick M ^a   Seyfried, Nicholas T ^a   Dammer, Eric B ^a   Duong, Duc ^a   Yi, Hong ^b   Gearing, Marla ^a   Troncoso, Juan C ^c   Mufson, Elliott J ^d   Thambisetty, Madhav ^e   Levey, Allan I ^a   Lah, James J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d RUSH MEDICAL COLLEGE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Down syndrome; Presenilin; SmD; snRNP; Spliceosome; U1 70k

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PRESENILIN 1; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN GENE; ARTICLE; AUTOPSY; AUTOSOMAL DOMINANT INHERITANCE; BRAIN; BRAIN CORTEX; CONTROLLED STUDY; CYTOPLASM; DOWN SYNDROME; FEMALE; GENE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD LABELING; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PAIRED HELICAL FILAMENT; PRESENILIN 1 GENE; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; PROTEOMICS; QUANTITATIVE ANALYSIS; ULTRASTRUCTURE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; DOWN SYNDROME; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; MUTATION; PRESENILIN-1; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR;

EID: 84900486688     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-9-15     Document Type: Article

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