Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes

Hormone and Metabolic Research

Volumn 46, Issue 5, 2014, Pages 341-347

  Hill, H S ^a   Grams, J ^b,c   Walton, R G ^a   Liu, J ^a   Moellering, D R ^a   Garvey, W T ^a,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

adipocyte biology; glucose homeostasis; metabolism

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; INSULIN; INTERLEUKIN 10; INTERLEUKIN 6; OSTEOCALCIN; TUMOR NECROSIS FACTOR ALPHA; GLUCOSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOXYLATION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLOGY; DECARBOXYLATION; DOSE RESPONSE; FATTY ACID SYNTHESIS; GLUCOSE HOMEOSTASIS; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLUCOSE TRANSPORT SYSTEM; IN VITRO STUDY; INFLAMMATION; INSULIN SENSITIVITY; LIPOGENESIS; LIPOLYSIS; MALE; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN PROCESSING; RAT; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; GLUCOSE; INSULIN; INTERLEUKIN-10; INTERLEUKIN-6; LIPOGENESIS; LIPOLYSIS; MALE; MICE; MICE, INBRED C57BL; OSTEOCALCIN; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, WISTAR;

EID: 84900484769     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1368709     Document Type: Article

References (23)

1. Lee N. K., Sowa H., Hinoi E., Ferron M., Ahn J. D., Confavreux C., Dacquin R., Mee P. J., McKee M. D., Jung D. Y., Zhang Z., Kim J. K., Mauvais-Jarvis F., Ducy P., Karsenty G. Endocrine regulation of energy metabolism by the skeleton. Cell: 2007; 130 456 469 (Pubitemid 47208519)
2. Rached M-T, Kode A., Silva B. C., Jung D. Y., Gray S., Ong H., Paik J-H, DePinho R. A., Kim J. K., Karsenty G., Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest: 2010; 120 357 368
3. Ferron M., Hinoi E., Karsenty G., Ducy P. Osteocalcin differentially regulates β-cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA: 2008; 105 5266 5270 (Pubitemid 351738545)
4. Botolin S., McCabe L. R. Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice. Endocrinology: 2007; 148 198 205 (Pubitemid 46021451)
5. Kindbloom J. M., Ohlsson C., Ljunggren O., Karlsson M. K., Tivesten Å, Smith U., Mellström D. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res: 2009; 24 785 791
6. Shea M. K., Gundberg C. M., Meigs J. B., Dallal G. E., Saltzman E., Yoshida M., Jacques P. F., Booth S. L. γ-Carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr: 2009; 90 1230 1235
7. Reinehr T., Roth C. L. A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin, and insulin resistance in obese children before and after weight loss. Int J Obesity: 2010; 34 852 858
8. Saleem U., Mosley T. H., Kullo I. J. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol: 2010; 30 1474 1478
9. Fulzele K., Riddle R. C., DiGirolamo D. J., Cao X., Wan C., Chen D., Faugere M. C., Aja S., Hussain M. A., Brüning J. C., Clemens T. L. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell: 2010; 142 309 319
10. Gundberg C. M., Hauschka P. V., Lian J. B., Gallop P. M. Osteocalcin-isolation characterization and detection. Methods in Enzymol: 1984; 107 526 544
11. Digirolamo M., Medlinger S., Fertig J. W. A simple method to determine fat cell size and number in four mammalian species. Am J Physiol: 1971; 221 850 858
12. Garvey W. T., Olefsky J. M., Matthaei S., Marshall S. Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes: a new mechanism of insulin resistance. J Biol Chem: 1987; 262 189 197 (Pubitemid 17000002)
13. Wang Q., Somwar R., Bilan P. J., Liu Z., Jin J., Woodgett J. R., Klip A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol: 1999; 19 4008 4018 (Pubitemid 29241975)
14. Mayor P., Maianu L., Garvey W. T. Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H1 myocytes: effects on glucose transporter gene expression. Diabetes: 1992; 41 274 285
15. Lima F. B., Bao S., Garvey W. T. Biologic actions of insulin are differentially regulated by glucose and insulin in primary cultured adipocytes: chronic ability to increase glycogen synthase activity. Diabetes: 1994; 43 53 62
16. Mick G. J., Wang X., Ling Fu C., McCormick K. L. Inhibition of leptin secretion by insulin and metformin in cultured rat adipose tissue. Biochim Biophys Acta: 2000; 1502 426 432
17. Ferron M., Wei J., Yoshizawa T., Ducy P., Karsenty G. An ELISA-based method to quantify osteocalcin carboxylation in mice. Biochem Biophys Res Commun: 2010; 397 691 696
18. Zhou B., Li H., Xu L., Zang W., Wu S., Sun H. Osteocalcin reverses endoplasmic reticulum stress and improves impaired insulin sensitivity secondary to diet-induced obesity through nuclear factor-kB signaling pathway. Endocrinology: 2013; 154 1055 1068
19. Hwang Y. C., Jeong I. K., Ahn K. J., Chung H. Y. The uncarboxylated form of osteocalcin is associated with improved glucose intolerance and enhanced β-cell function in middle-aged male subjects. Diabetes Metab Res Rev: 2009; 25 768 772
20. Kanazawa I., Yamaguchi T., Yamaguch M., Yamamoto M., Kruioka S., Yano S., Sugimoto T. Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int: 2011; 22 187 194
21. Pollock N. K., Bernard P. J., Gower B. A., Gundberg C. M., Wenger K., Misra S., Bassali R. W., Davis C. L. Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with β-cell function. J Clin Endocrinol Metab: 2011; 96 E1092 E1099
22. Foresta C., Strapazzon G., De Toni L., Gianesello L., Calcagno A., Pilon C., Plebani M., Vettor R. Evidence for osteocalcin production by adipose tissue and its role in human metabolism. J Clin Endocrinol Metab: 2010; 95 3502 3506
23. Brennan-Speranza T. C., Henneicke H., Gasparini S. J., Blankenstein K. I., Heinevetter U., Cogger V. C., Svistounov D., Zhang Y., Cooney G. J., Buttgereit F., Dunstan C. R., Gundberg C., Zhou H., Seibel M. J. Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. J Clin Invest: 2013; 122 4172 4189