Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

Biochemical Journal

Volumn 460, Issue 2, 2014, Pages 165-175

  Van Der Wijst, Jenny ^a   Blanchard, Maxime G ^b   Woodroof, Helen I ^a   Macartney, Thomas J ^a   Gourlay, Robert ^a   Hoenderop, Joost G ^b   Bindels, Reńe J ^b   Alessi, Dario R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Dimerization motif; Hypomagnesaemia; Ion channel; Phosphorylation; Protein kinase; Transient receptor potential melastatin (TRPM)

Indexed keywords

MUTANT PROTEIN; PROTEIN KINASE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M6;

ARTICLE; AUTOPHOSPHORYLATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; MISSENSE MUTATION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN MOTIF; REGULATORY MECHANISM; SEQUENCE ANALYSIS;

HEK293 CELLS; HUMANS; HYPOCALCEMIA; MAGNESIUM; PROTEIN KINASES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; TRPM CATION CHANNELS;

EID: 84900483022     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20131639     Document Type: Article

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