Descriptive epidemiology of cancer of unknown primary site in Scotland, 1961-2010

Cancer Epidemiology

Volumn 38, Issue 3, 2014, Pages 227-234

  Brewster, David H ^a   Lang, Jaroslaw ^a   Bhatti, Lesley A ^a   Thomson, Catherine S ^a   Oien, Karin A ^b  

^a INFORMATION SERVICES DIVISION   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Epidemiology; Incidence; Neoplasm metastasis; Neoplasms, Unknown primary; Survival

Indexed keywords

AGE; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER MORTALITY; CANCER OF UNKNOWN PRIMARY SITE; CANCER REGISTRY; CANCER SURVIVAL; CAUSE OF DEATH; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; HUMAN; ICD-10; KAPLAN MEIER METHOD; LUNG CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NON MELANOMA SKIN CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SQUAMOUS CELL CARCINOMA; TUMOR INVASION; UNITED KINGDOM; ADOLESCENT; ADULT; AGED; CHILD; INCIDENCE; INFANT; METASTASIS; MIDDLE AGED; MORTALITY; NEOPLASMS, UNKNOWN PRIMARY; NEWBORN; PATHOLOGY; PRESCHOOL CHILD; SURVIVAL; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INCIDENCE; INFANT; INFANT, NEWBORN; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASMS, UNKNOWN PRIMARY; SCOTLAND; SURVIVAL ANALYSIS; YOUNG ADULT;

EID: 84900476493     PISSN: 18777821     EISSN: 1877783X     Source Type: Journal    
DOI: 10.1016/j.canep.2014.03.010     Document Type: Article

References (32)

1. Pavlidis N., Pentheroudakis G. Cancer of unknown primary site. Lancet 2012, 379:1428-1435.
2. Muir C. Cancer of unknown primary site. Cancer 1995, 75(1 Suppl):353-356.
3. van de Wouw A.J., Janssen-Heijnen M.L., Coebergh J.W., Hillen H.F. Epidemiology of unknown primary tumours; incidence and population-based survival of 1285 patients in Southeast Netherlands, 1984-1992. Eur J Cancer 2002, 38:409-413.
4. Levi F., Te V.C., Erler G., Randimbison L., La Vecchia C. Epidemiology of unknown primary tumours. Eur J Cancer 2002, 38:1810-1812.
5. Luke C., Koczwara B., Karapetis C., Pittman K., Price T., Kotasek D., et al. Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care. Aust NZ J Public Health 2008, 32:383-389.
6. Shu X., Sundquist K., Sundquist J., Hemminki K. Time trends in incidence, causes of death, and survival of cancer of unknown primary in Sweden. Eur J Cancer Prev 2012, 21:281-288.
7. Cancer Research UK. Cancer of Unknown Primary Statistics. Available at: [accessed 19.02.14]. http://www.cancerresearchuk.org/cancer-info/cancerstats/types/cancer-of-unknown-primary/%3Fscript=true.
8. Urban D., Rao A., Bressel M., Lawrence Y.R., Mileshkin L. Cancer of unknown primary: a population-based analysis of temporal change and socioeconomic disparities. Br J Cancer 2013, 109:1318-1324.
9. Brustugun O.T., Helland A. Rapid reduction in the incidence of cancer of unknown primary: a population-based study. Acta Oncol 2014, 53:134-137.
10. Cancer incidence in five continents, volume IX. IARC Scientific Publications No. 160 2007, International Agency for Research on Cancer, Lyon. M.P. Curado, B. Edwards, H.R. Shin, H. Storm, J. Ferlay, M.-A. Heanue (Eds.).
11. World Health Organisation (WHO) International statistical classification of diseases and related problems, 10th revision 2011, WHO, Geneva. 4th ed.
12. National Institute for Health and Clinical Excellence (NICE) Diagnosis and management of metastatic malignant disease of unknown primary origin 2010, National Collaborating Centre for Cancer, Cardiff.
13. Riihimäki M., Hemminki A., Sundquist K., Hemminki K. Time trends in survival from cancer of unknown primary: small steps forward. Eur J Cancer 2013, 49:2403-2410.
14. Bevier M., Sundquist J., Hemminki K. Incidence of cancer of unknown primary in Sweden: analysis by location of metastasis. Eur J Cancer Prev 2012, 21:596-601.
15. Hemminki K., Bevier M., Hemminki A., Sundquist J. Survival in cancer of unknown primary site: population-based analysis by site and histology. Ann Oncol 2012, 23:1854-1863.
16. Randén M., Rutqvist L.E., Johansson H. Cancer patients without a known primary: incidence and survival trends in Sweden 1960-2007. Acta Oncol 2009, 48:915-920.
17. Brewster D., Crichton J., Harvey J.C., Dawson G. Completeness of case ascertainment in a Scottish Regional Cancer Registry for the year 1992. Public Health 1997, 111:339-343.
18. Brewster D.H., Stockton D., Harvey J., Mackay M. Reliability of cancer registration data in Scotland, 1997. Eur J Cancer 2002, 38:414-417.
19. Kendrick S., Clarke J. The Scottish record linkage system. Health Bull (Edinb) 1993, 51:72-79.
20. Kendrick S. The development of record linkage in Scotland: the responsive application of probability matching. Record Linkage Techniques - 1997: Proceedings of an International Workshop and Exposition, Arlington, VA, March 20-21, 1997 1997, 319-332. Federal Committee on Statistical Methodology, Office of Management and Budget, Washington DC, [chapter 10, Available at: http://www.fcsm.gov/working-papers/skendrick.pdf, accessed 19.02.14]. W. Alvey, B. Jamerson (Eds.).
21. Scottish Government The Scottish Index of Multiple Deprivation (SIMD), 2006 [Available from: , accessed 19.02.14]. http://www.scotland.gov.uk/Topics/Statistics/SIMD.
22. Cancer incidence in five continents, volume III. IARC Scientific Publications No. 15 1976, 454-459. International Agency for Research on Cancer, Lyon. J. Waterhouse, C. Muir, P. Correa, J. Powell (Eds.).
23. Fay M.P., Feuer E.J. Confidence intervals for directly standardized rates: a method based on the gamma distribution. Stat Med 1997, 16:791-801.
24. Kaplan E.L., Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958, 53:457-481.
25. Schwartz E., Kofie V.Y., Sturgeon S.R. Racial differences in ill defined cancer mortality in the United States and in the District of Columbia. J Epidemiol Community Health 1992, 46:390-393.
26. ISD Scotland. Cancer Statistics [Available at: , accessed 19.02.14]. http://www.isdscotland.org/Health-Topics/Cancer/Cancer-Statistics/All-Types-of-Cancer/.
27. Hemminki K., Bevier M., Sundquist J., Hemminki A. Site-specific cancer deaths in cancer of unknown primary diagnosed with lymph node metastasis may reveal hidden primaries. Int J Cancer 2013, 132:944-950.
28. Hemminki K., Riihimäki M., Sundquist K., Hemminki A. Site-specific survival rates for cancer of unknown primary according to location of metastases. Int J Cancer 2013, 133:182-189.
29. Swaro A., Adhiyaman V. Autopsy in older medical patients: concordance in ante- and post-mortem findings and changing trends. J R Coll Phys Edinb 2010, 40:205-208.
30. Roulson J., Benbow E.W., Hasleton P.S. Discrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review. Histopathology 2005, 47:551-559.
31. Maudsley G., Williams E.M. Death certification by house officers and general practitioners - practice and performance. J Public Health Med 1993, 15:192-201.
32. Oien K.A., Dennis J.L. Diagnostic work-up of carcinoma of unknown primary: from immunohistochemistry to molecular profiling. Ann Oncol 2012, 23(Suppl 10):x271-x277.