Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: Implications for research and clinical care

Australian and New Zealand Journal of Public Health

Volumn 32, Issue 4, 2008, Pages 383-389

  Luke, Colin ^a   Koczwara, Bogda ^b   Karapetis, Christos ^b   Pittman, Ken ^c   Price, Tim ^c   Kotasek, Dusan ^d   Beckmann, Kerri ^e   Brown, Michael P ^f   Roder, David ^e  

^a DEPARTMENT OF HEALTH   (Australia)

^b FLINDERS MEDICAL CENTRE   (Australia)

^c QUEEN ELIZABETH HOSPITAL   (Australia)

^d Adelaide Cancer Centre   (Australia)

^e CANCER COUNCIL SOUTH AUSTRALIA   (Australia)

^f ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Cancer unknown primary; Incidence; Mortality; Survival

Indexed keywords

ADENOCARCINOMA; ADULT; AGED; ARTICLE; AUSTRALIA; CANCER CLASSIFICATION; CANCER INCIDENCE; CANCER MORTALITY; CANCER OF UNKNOWN PRIMARY SITE; CANCER REGISTRY; CANCER RISK; CANCER SURVIVAL; CONTROLLED STUDY; EPIDEMIOLOGICAL DATA; FEMALE; HISTOPATHOLOGY; HUMAN; INDIGENOUS PEOPLE; MAJOR CLINICAL STUDY; MALE; PATIENT CARE; RACE DIFFERENCE; SEX DIFFERENCE; SOCIAL STATUS; TREND STUDY;

ADULT; AGED; AGED, 80 AND OVER; EPIDEMIOLOGIC METHODS; EPIDEMIOLOGIC STUDIES; FEMALE; HUMANS; INCIDENCE; LOGISTIC MODELS; MALE; MIDDLE AGED; NEOPLASMS, UNKNOWN PRIMARY; PHYSICIAN'S PRACTICE PATTERNS; PILOT PROJECTS; PUBLIC HEALTH; PUBLIC HEALTH PRACTICE; REGISTRIES; RISK FACTORS; SOCIOECONOMIC FACTORS; SOUTH AUSTRALIA;

EID: 50449101288     PISSN: 13260200     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-6405.2008.00260.x     Document Type: Article

References (40)

1. Australian Institute of Health and Welfare. Cancer in Australia: An Overview, 2006. Canberra (AUST): AIHW; 2007. Cancer Series No.: 37.
2. Shaw PH, Adams R, Jordan C, Crosby TD. A clinical review of the investigation and management of carcinoma of unknown primary in a single cancer network. Clin Oncol (R Coll Radiol). 2007;19(1):87-95.
3. Muir C. Cancer of unknown primary site. Cancer. 1995;75 Suppl 1:353-6.
4. Levi F, Te VC, Erler G, Randimbison L, La Vecchia C. Epidemiology of unknown primary tumours. Eur J Cancer. 2002;38(13):1810-2.
5. Parkin DM, Whelan SL, Ferlay J, Teppe L, Thomas DB, editors. Cancer Incidence in Five Continents. Vol. VIII. Lyon (FRA): IARC Press; 2002. IARC Scientific Publication No.: 155.
6. Parkin DM, Chen VW, Ferlay J, Galceran J, Storm HH, Whelan SL, editors. Comparability and Quality Control in Cancer Registration. Lyon (FRA): IARC Press; 1994. IARC Technical Report No.: 19.
7. Pavlidis N, Briasoulis E, Hainsworth J, Greco EA. Diagnostic and therapeutic management of cancer of unknown primary. Eur J Cancer. 2003;39(14): 1990-2005.
8. Hillen HF. Unknown primary tumours. Postgrad Med J. 2000;76(901):690-3.
9. Pentheroudakis G, Briasoulis E, Pavlidis N. Cancer of unknown primary site: missing primary or missing biology? Oncologist. 2007;12(4):418-25.
10. van de Wouw AJ, Jansen RL, Speel EJ, Hillen HF. The unknown biology of the unknown primary tumour. A literature review. Ann Oncol. 2003;14(2):191-6.
11. Tracey E, Bishop J, Glass P, Roder D, Currow D, Jelfs P. Unknown Primary Cancer in NSW. Sydney (AUST): New South Wales Cancer Institute; 2007.
12. English D, Farrugia H, Thursfield V, Chang P, Giles G. Cancer Survival Victoria 2007: Estimates of Survival in 2004 (and Comparisons with Earlier Periods). Melbourne (AUST): Victorian Cancer Registry, Epidemiology Centre; 2007.
13. Pentheroudakis G, Briasoulis E, Karavassilis V, Fountzilas G, Xeros N, Samelis G, et al. Chemotherapy for patients with favourable subsets of unknown primary carcinoma: active, but how effective? Acta Oncol. 2005;44(2):155-60.
14. Jentsch-Ullrich K, Kalinski T, Roessner A, Franke A, Mohren M. Long-term remission in a patient with carcinoma of unknown primary site. Chemotherapy. 2006;52(1):12-5.
15. Greco FA, Litchy S, Dannaher C, Hermann RC, Pati A, Hon J, et al. Carcinoma of unknown primary site with unfavourable characteristics: Survival of 396 patients after treatment in five consecutive phase II trials by the Minnie Pearl Cancer Research Network. J Clin Oncol. 2004;22 Suppl 14:4186.
16. Greco FA, Rodriguez GI, Shaffer DW, Hermann R, Litchy S, Yardley DA, et al. Carcinoma of unknown primary site: sequential treatment with paclitaxel/carboplatin/etoposide and gemcitabine/irinotecan: a Minnie Pearl Cancer Research Network Phase II trial. Oncologist. 2004;9(6):644-52.
17. Pittman KB, Olver IN, Koczwara B, Kotasek D, Patterson WK, Keefe DM, et al. Adelaide CancerTrials and Education Collaborative (ACTEC). Gemcitabine and carboplatin in carcinoma of unknown primary site: a phase 2 Adelaide Cancer Trials and Education Collaborative study. Br J Cancer 2006;95(10):1309-13.
18. Abbruzzese JL, Abbruzzese MC, Lenzi R, Hess KR, Raber MN. Analysis of a diagnostic strategy for patients with suspected tumors of unknown origin. J Clin Oncol. 1995;13(8):2094-103.
19. South Australian Cancer Registry. Epidemiology of Cancer in South Australia. Incidence, Mortality and Survival 1977 to 2000. Incidence and Mortality 2000. Adelaide (AUST): Openbook Publishers; 2001.
20. South Australian Cancer Registry. Epidemiology of Cancer in South Australia. Incidence, Mortality and Survival 1977 to 1992. Incidence and Mortality 1992. Adelaide (AUST): Lutheran Press; 1993.
21. South Australian Cancer Registry. Epidemiology of Cancer in South Australia. Incidence, Mortality and Survival 1977 to 1999. Incidence and Mortality 1999. Adelaide (AUST): Openbook Publishers; 2000.
22. Bonett A, Roder D, Esterman A. Cancer case-survival rates for South Australia: a comparison with US rates and a preliminary investigation of time trends. Med J Aust. 1988;148(11):556-9.
23. Carter KJ, Rinehart S, Kessler E, Caccamo LP, Ritchey NP, Erickson BA, et al. Quality assurance in anatomic pathology: automated SNOMED coding. J Am Med Inform Assoc. 1996;3(4):270-2.
24. Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide. Version 1.0. Lyon (FRA): IARC Press; 2001. IARC Cancer Base No.: 5.
25. Australian Bureau of Statistics. 1996 Census of Population and Housing. Socio-economic Indexes for Areas. Canberra (AUST): ABS; 1998.
26. STATA: statistical software [computer software]. Version 9.2. College Station (TX): Stata Corporation; 2005.
27. Armitage P, Berry G. Statistical Methods in Medical Research. Oxford (UK): Blackwell Scientific Publications; 1987.
28. Dobson AJ, Kuulasmaa K, Eberle E, Scherer J. Confidence intervals for weighted sums of Poisson parameters. Stat Med. 1991;10:457-62.
29. South Australian Cancer Registry. Epidemiology of Cancer in South Australia. Incidence, Mortality and Survival 1977 to 1996. Incidence and Mortality 1996. Adelaide (AUST): Openbook Publishers; 1997.
30. Centre for Cancer Control Research. Time Trends in Cancer Mortality in South Australia between 1990 and 2001. Adelaide (AUST): The Cancer Council South Australia; 2005. South Australian Cancer Statistics Monograph No.: 8.
31. Australian Institute of Health and Welfare. Australian Cancer Incidence and Mortality Books. Canberra (AUST): AIHW; 2007.
32. Devita VT, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia (PA): Lippincott, Williams & Wilkins; 2004.
33. Luke CG, Koczwara B, Moore JWE, Olver IN, Pittman K, Permiment M, et al. Treatment and survival from colorectal. cancer; the experience of patients at South Australian teaching hospitals between 1980 and 2002. Clin Oncol (R Coll Radiol). 2005;17(5):372-81.
34. Kole AL, Nieweg OE, Pruim J, Hoekstra HJ, Koops HS, Roodenburg JL, et al. Detection of unknown occult primary tumors using positron emission tomography. Cancer. 1998;82(6):1160-6.
35. Lassen U, Daugaard G, Eigtved A, Damgaard K, Friberg L. 18F-FDG whole body positron emission tomography (PET) in patients with unknown primary tumours (UPT). Eur J Cancer. 1999;35(7):1076-82.
36. Eustace S, Tello R, DeCarvalho V, Carey J, Melhem E, Yucel EK. Whole body turbo STIR MRI in unknown primary tumor detection. J Magn Reson Imaging. 1998;8(3):751-3.
37. South Australian Cancer Registry. Cancer in South Australia 2004 with Incidence Projections to 2007. Adelaide (AUST): Department of Health; 2007.
38. Roder D. Epidemiology of cancer in Indigenous Australians: implications for service delivery. Cancer Forum. 2007;31:85-90.
39. Condon JR, Barnes T, Cunningham J, Armstrong BK. Long-term trends in cancer mortality for Indigenous Australians in the Northern Territory. Med J Aust. 2004;180(10):504-7.
40. Massard C, Voigt JJ, Laplanche A, Culine S, Lortholary A, Bugat R, et al. Carcinoma of an unknown primary: are EGF receptor, Her-2/neu, and c-Kit tyrosine kinases potential targets for therapy? Br J Cancer. 2007;97(7): 857-61.