AMP-activated protein kinase activation leads to lysome-mediated NA +/I--symporter protein degradation in rat thyroid cells

Hormone and Metabolic Research

Volumn 46, Issue 5, 2014, Pages 313-317

  Cazarin, J M ^a   Andrade, B M ^a   Carvalho, D P ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

AMPK; Bafilomycin A1; iodide uptake; NIS degradation

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IODIDE; MITOGEN ACTIVATED PROTEIN KINASE; SODIUM IODIDE SYMPORTER; THYROTROPIN; COTRANSPORTER;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; THYROID FOLLICLE CELL; ANIMAL; CYTOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; THYROID GLAND;

RATTUS;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ENZYME ACTIVATION; IODIDES; LYSOSOMES; PROTEOLYSIS; RATS; SYMPORTERS; THYROID GLAND; THYROTROPIN;

EID: 84900475656     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0034-1371803     Document Type: Article

References (18)

1. Bizhanova A., Chop P. The Sodium-Iodide Symporter NIS and Pendrin in Iodide Homeostasis of the Thyroid. Endocrinology: 2009; 150 1084 1090
2. De la Vieja A., Dohan O., Levy O., Carrasco N. Molecular Analysis of the Sodium/Iodide Symporter: Impact on Thyroid and Extrathyroid Pathophysiology. Physiol Rev. 2000; 80 1083 1105
3. Wang W., Larson S. M., Tuttle R. M., Kalaigian H., Kolbert K., Sonenberg M., Robbins R. J. Resistance of [18F]-fluorodeoxyglucose-avid metastatic thyroid cancer lesions to treatment with high-dose radioactive iodine. Thyroid: 2001; 12 1169 1175 (Pubitemid 34041898)
4. Riedel C., Levy O., Carrasco N. Post-transcriptional regulation of the sodium/iodide symporter by thyrotropin. J Biol Chem: 2001; 276 21458 21463
5. - symporter and iodide uptake in the rat thyroid gland. Am J Physiol Cell Physiol: 2011; 300 C1291 C1297
6. Hardie D. G. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev: 2011; 25 1895 1908
7. Andrade B. M., Cazarin J., Zancan P., Carvalho D. P. AMP-activated protein kinase upregulates glucose uptake in thyroid PCCL3 cells independent of thyrotropin. Thyroid: 2012; 22 1063 1068
8. - symporter protein degradation in human breast cancer cells. Endocr Relat Cancer: 2013; 20 241 250
9. Abdulrahman R., Boon M. R., Sips H. C., Guigas B. G., Rensen P. C., Smit J. W., Hovens G. C. Impact of Metformin and Compound C on NIS expression and iodine uptake in vitro and in vivo: a role for CRE in AMPK modulation of thyroid function. Thyroid: 2014; 24 78 87
10. Weiss J., Philp N. J., Ambesi-Impiombato F. S., Grollman E. F. Thyrotropin-stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis. Endocrinology: 1984; 114 1099 1107 (Pubitemid 14134352)
11. Garcia B., Santisteban P. PI3K is involved in the IGF-1 inhibition of TSH-induced sodium/iodide symporter gene expression. J Endocrinol: 2002; 16 342 352 (Pubitemid 34131229)
12. Zaballos M. A., Garcia B., Santisteban P. Gβγ dimers released in response to thyrotropin activate phosphoinositide 3-kinase and regulate gene expression in thyroid cells. Mol Endocrinol: 2008; 22 1183 1199 (Pubitemid 351629618)
13. Vadysirisack D. D., Chen ES W., Zhang Z., Tsai M. D., Chang G. D., Jhiang S. M. Identification of in Vivo Phosphorylation Sites and Their Functional Significance in the Sodium Iodide Symporter. J Biol Chem: 2007; 282 36820 36828
14. - targeting to the membrane. Endocr Relat Cancer: 2006; 13 257 269
15. Lamy F., Taton M., Dumont J. E., Roger P. P. Control of protein synthesis by thyrotropin and epidermal growth factor in human thyrocytes: role of morphological changes. Mol Cell Endocrinol: 1990; 73 195 209 (Pubitemid 20345391)
16. Hébrant A., van Staveren W. C., Delys L., Solís D. W., Bogdanova T., Andry G., Roger P., Dumont J. E., Libert F., Maenhaut C. Long-term EGF/serum-treated human thyrocytes mimic papillary thyroid carcinomas with regard to gene expression. Exp Cell Res: 2007; 313 3276 3284 (Pubitemid 47284058)
17. Choi H. J., Kim T. Y., Chung N., Yim J. H., Kim W. G., Kim J. A., Kim W. B., Shong Y. K. The influence of the BRAF V600E mutation in thyroid cancer cell lines on the anticancer effects of 5-aminoimidazole-4-carboxamide- ribonucleoside. J Endocrinol: 2011; 211 79 85
18. Vidal A. P., Andrade B. M., Vaisman F., Cazarin J., Pinto L. F., Breitenbach M. M., Corbo R., Caroli-Bottino A., Soares F., Vaisman M., Carvalho D. P. AMP-activated protein kinase signaling is upregulated in papillary thyroid cancer. Eur J Endocrinol: 2013; 169 521 528 Nível Superior