Serum metabolites related to cardiorespiratory fitness, physical activity energy expenditure, sedentarytime and vigorous activity

International Journal of Sport Nutrition and Exercise Metabolism

Volumn 24, Issue 2, 2014, Pages 215-226

  Wientzek, Angelika ^a   Floegel, Anna ^a   Knüppel, Sven ^a   Vigl, Matthaeus ^a   Drogan, Dagmar ^a   Adamski, Jerzy ^c   Pischon, Tobias ^b   Boeing, Heiner ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Methionine; Phosphatidylcholines; Physical fitness

Indexed keywords

ARGININE; GLUTAMINE; HEXOSE; HISTIDINE; ISOLEUCINE; LYSOPHOSPHATIDYLCHOLINE; METHIONINE; ORNITHINE; PHENYLALANINE; PROLINE; SPHINGOMYELIN; VALINE;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MOVEMENT; CARDIOPULMONARY FUNCTION; CARDIORESPIRATORY FITNESS; DIET RESTRICTION; ENERGY EXPENDITURE; FEMALE; FLOW INJECTION ANALYSIS; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLITE; METABOLOMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHOSPHOLIPID BLOOD LEVEL; PHYSICAL ACTIVITY; SEDENTARY LIFESTYLE; SENSOR; SMOKING; TANDEM MASS SPECTROMETRY; VIGOROUS ACTIVITY; VOCATIONAL EDUCATION; BLOOD; DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; EXERCISE; EXERCISE TEST; FITNESS; MIDDLE AGED; MOVEMENT (PHYSIOLOGY); PHYSIOLOGY; RISK FACTOR;

DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; EXERCISE; EXERCISE TEST; FEMALE; HEART RATE; HUMANS; LYSOPHOSPHATIDYLCHOLINES; MALE; METHIONINE; MIDDLE AGED; MOVEMENT; PHYSICAL EXERTION; PHYSICAL FITNESS; RISK FACTORS; SEDENTARY LIFESTYLE; TANDEM MASS SPECTROMETRY;

EID: 84900463196     PISSN: 1526484X     EISSN: 15432742     Source Type: Journal    
DOI: 10.1123/ijsnem.2013-0048     Document Type: Article

References (48)

1. Banfi, G., Colombini, A., Lombardi, G., & Lubkowska, A. (2012). Metabolic markers in sports medicine. Advances in Clinical Chemistry, 56, 1-54. PubMed doi:10.1016/B978-0-12-394317-0.00015-7
2. Benjamini Y, H. Y. (1995). Controlling the false discovery rate: A Practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B. Methodological, 57, 289-300.
3. Boeing, H., Korfmann, A., & Bergmann, M.M. (1999a). Recruitment procedures of EPIC-Germany. European Investigation into Cancer and Nutrition. Annals of Nutrition & Metabolism, 43 (4), 205-215. PubMed doi:10.1159/000012787
4. Boeing, H., Wahrendorf, J., & Becker, N. (1999b). EPIC-Germany - A source for studies into diet and risk of chronic diseases. European investigation into cancer and nutrition. Annals of Nutrition & Metabolism, 43(4), 195-204.
5. Bouchard, C., & Rankinen, T. (2001). Individual differences in response to regular physical activity. Med Sci Sports Exerc, 33(6 Suppl.), S446-451; discussion S452-443.
6. Bouchard, C., Sarzynski, M.A., Rice, T.K., Kraus, W.E., Church, T.S., Sung, Y.J., . . . Rankinen, T. (2011). Genomic predictors of the maximal O(2) uptake response to standardized exercise training programs. Journal of Applied Physiology (Bethesda, Md.:1985), 110(5), 1160-1170. PubMed
7. Brage, S., Brage, N., Franks, P.W., Ekelund, U., & Wareham, N.J. (2005). Reliability and validity of the combined heart rate and movement sensor Actiheart. European Journal of Clinical Nutrition, 59(4), 561-570. PubMed doi:10.1038/sj.ejcn.1602118
8. Brage, S., Brage, N., Franks, P.W., Ekelund, U., Wong, M.Y., Andersen, L.B., . . . Wareham, N.J. (2004). Branched equation modeling of simultaneous accelerometry and heart rate monitoring improves estimate of directly measured physical activity energy expenditure. Journal of Applied Physiology (Bethesda, Md.:1985), 96(1), 343-351. PubMed
9. Brage, S., Ekelund, U., Brage, N., Hennings, M.A., Froberg, K., Franks, P.W., & Wareham, N.J. (2007). Hierarchy of individual calibration levels for heart rate and accelerometry to measure physical activity. Journal of Applied Physiology (Bethesda, Md:1985.), 103(2), 682-692. PubMed
10. Caspersen, C.J., Powell, K.E., & Christenson, G.M. (1985). Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Reports (Washington, D.C:.1974), 100 (2), 126-131. PubMed
11. Chorell, E., Svensson, M.B., Moritz, T., & Antti, H. (2012). Physical fitness level is reflected by alterations in the human plasma metabolome. Molecular BioSystems, 8(4), 1187-1196. PubMed doi:10.1039/c2mb05428k
12. Clarke, R., Daly, L., Robinson, K., Naughten, E., Cahalane, S., Fowler, B., & Graham, I. (1991). Hyperhomocysteinemia: an independent risk factor for vascular disease. The New England Journal of Medicine, 324(17), 1149-1155. PubMed doi:10.1056/NEJM199104253241701
13. Cole, L.K., Vance, J.E., & Vance, D.E. (2012). Phosphatidylcholine biosynthesis and lipoprotein metabolism. Biochimica et Biophysica Acta, 1821(5), 754-761. PubMed doi:10.1016/j.bbalip.2011.09.009
14. Donath, M.Y., & Shoelson, S.E. (2011). Type 2 diabetes as an inflammatory disease. Nature Reviews. Immunology, 11(2), 98-107 10.1038/nri2925. PubMed doi:10.1038/nri2925
15. Drobnik, W., Liebisch, G., Audebert, F.X., Frohlich, D., Gluck, T., Vogel, P., . . . Schmitz, G. (2003). Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. Journal of Lipid Research, 44(4), 754-761. PubMed doi:10.1194/jlr.M200401-JLR200
16. Fahy, E., Sud, M., Cotter, D., & Subramaniam, S. (2007). LIPID MAPS online tools for lipid research. Nucleic Acids Res, 35(Web Server issue), W606-612.
17. Floegel, A., Drogan, D., Wang-Sattler, R., Prehn, C., Illig, T., Adamski, J., . . . Pischon, T. (2011). Reliability of serum metabolite concentrations over a 4-month period using a targeted metabolomic approach. PLoS ONE, 6(6), e21103. PubMed doi:10.1371/journal.pone.0021103
18. Floegel, A., Stefan, N., Yu, Z., Muhlenbruch, K., Drogan, D., Joost, H. G., . . . Pischon, T. (2013a). Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach. Diabetes.
19. Floegel, A., von Ruesten, A., Drogan, D., Schulze, M.B., Prehn, C., Adamski, J., . . . Boeing, H. (2013b). Variation of serum metabolites related to habitual diet: a targeted metabolomic approach in EPIC-Potsdam. European Journal of Clinical Nutrition, 10.1038/ejcn.2013.147. PubMed
20. Hung, N.D., Sok, D.E., & Kim, M.R. (2012). Prevention of 1-palmitoyl lysophosphatidylcholine-induced inflammation by polyunsaturated acyl lysophosphatidylcholine. Inflammation Research, 61 (5), 473-483. PubMed doi:10.1007/s00011-012-0434-x
21. InterActConsortium. (2012). Physical activity reduces the risk of incident Type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study. Diabetologia, 55(7), 1944-1952. PubMed doi:10.1007/s00125-012-2532-2
22. Joubert, L.M., & Manore, M.M. (2006). Exercise, nutrition, and homocysteine. International Journal of Sport Nutrition and Exercise Metabolism, 16(4), 341-361. PubMed (Pubitemid 44395034)
23. Krug, S., Kastenmuller, G., Stuckler, F., Rist, M.J., Skurk, T., Sailer, M., . . . Daniel, H. (2012). The dynamic range of the human metabolome revealed by challenges. FASEB Journal, 26(6), 2607-2619. PubMed doi:10.1096/fj.11-198093
24. Li, Z., & Vance, D.E. (2008). Phosphatidylcholine and choline homeostasis. Journal of Lipid Research, 49(6), 1187-1194. PubMed doi:10.1194/jlr.R700019-JLR200
25. Mann, N.J., Li, D., Sinclair, A.J., Dudman, N.P., Guo, X.W., Elsworth, G.R., . . . Kelly, F.D. (1999). The effect of diet on plasma homocysteine concentrations in healthy male subjects. European Journal of Clinical Nutrition, 53(11), 895-899. PubMed doi:10.1038/sj.ejcn.1600874
26. McCarney, R., Warner, J., Iliffe, S., van Haselen, R., Griffin, M., & Fisher, P. (2007). The Hawthorne Effect: a randomised, controlled trial. BMC Medical Research Methodology, 7, 30. PubMed doi:10.1186/1471-2288-7-30
27. Metzger, J.S., Catellier, D.J., Evenson, K.R., Treuth, M.S., Rosamond, W.D., & Siega-Riz, A.M. (2008). Patterns of objectively measured physical activity in the United States. Medicine and Science in Sports and Exercise, 40(4), 630-638. PubMed doi:10.1249/MSS.0b013e3181620ebc
28. Meyer zu Heringdorf, D., & Jakobs, K.H. (2007). Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochimica et Biophysica Acta, 1768(4), 923-940. PubMed doi:10.1016/j.bbamem.2006.09.026
29. Neilson, H.K., Robson, P.J., Friedenreich, C.M., & Csizmadi, I. (2008). Estimating activity energy expenditure: how valid are physical activity questionnaires? The American Journal of Clinical Nutrition, 87(2), 279-291. PubMed (Pubitemid 351226061)
30. Ojala, P.J., Hirvonen, T.E., Hermansson, M., Somerharju, P., & Parkkinen, J. (2007). Acyl chain-dependent effect of lysophosphatidylcholine on human neutrophils. Journal of Leukocyte Biology, 82(6), 1501-1509. PubMed doi:10.1189/jlb.0507292
31. Oresic, M. (2009). Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction. Nutrition, Metabolism, and Cardiovascular Diseases, 19(11), 816-824. PubMed doi:10.1016/j.numecd.2009.04.018
32. Refsum, H., Ueland, P.M., Nygard, O., & Vollset, S.E. (1998). Homocysteine and cardiovascular disease. Annual Review of Medicine, 49, 31-62. PubMed doi:10.1146/annurev.med.49.1.31
33. Riboli, E., & Kaaks, R. (1997). The EPIC Project: Rationale and study design. European prospective investigation into cancer and nutrition. International Journal of Epidemiology, 26(Suppl. 1), S6-S14. PubMed doi:10.1093/ije/26.suppl-1.S6
34. Romisch-Margl, W., Prehn, C., Bogumil, R., Rohring, C., Suhre, K., & Adamski, J. (2012). Procedure for tissue sample preparation and metabolite extraction for high-throughput targeted metabolomics. Metabolomics, 8 (1), 133-142. doi:10.1007/s11306-011-0293-4
35. Rose, G.A. (1962). The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bulletin of the World Health Organization, 27, 645-658. PubMed
36. Rundle, A. (2005). Molecular epidemiology of physical activity and cancer. Cancer Epidemiology, Biomarkers & Prevention, 14(1), 227-236. PubMed
37. Schmitz, G., & Ruebsaamen, K. (2010). Metabolism and atherogenic disease association of lysophosphatidylcholine. Atherosclerosis, 208(1), 10-18. PubMed doi:10.1016/j.atherosclerosis.2009.05.029
38. Schneider, H., Braun, A., Fullekrug, J., Stremmel, W., & Ehehalt, R. (2010). Lipid based therapy for ulcerative colitismodulation of intestinal mucus membrane phospholipids as a tool to influence inflammation. International Journal of Molecular Sciences, 11 (10), 4149-4164. PubMed doi:10.3390/ ijms11104149
39. Shephard, R.J. (1988). PAR-Q, Canadian Home Fitness Test and exercise screening alternatives. Sports Medicine (Auckland, N.Z.), 5 (3), 185-195. PubMed doi:10.2165/00007256-198805030-00005
40. Simmons, R.K., Griffin, S.J., Steele, R., Wareham, N.J., & Ekelund, U. (2008). Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial. Diabetologia, 51 (5), 787-794. PubMed doi:10.1007/s00125-008-0949-4
41. Sluik, D., Buijsse, B., Muckelbauer, R., Kaaks, R., Teucher, B., Johnsen, N.F., . . . Nothlings, U. (2012). Physical activity and mortality in individuals with diabetes mellitus: A prospective study and meta-analysis. Archives of Internal Medicine, 172(17), 1285-1295. PubMed
42. Stegle, O., Fallert, S.V., MacKay, D.J., & Brage, S. (2008). Gaussian process robust regression for noisy heart rate data. IEEE Transactions on Bio-Medical Engineering, 55(9), 2143-2151. PubMed doi:10.1109/TBME.2008.923118
43. Tanaka, H., Monahan, K.D., & Seals, D.R. (2001). Age-predicted maximal heart rate revisited. Journal of the American College of Cardiology, 37(1), 153-156. PubMed doi:10.1016/S0735-1097(00)01054-8
44. Treede, I., Braun, A., Sparla, R., Kuhnel, M., Giese, T., Turner, J.R., . . . Ehehalt, R. (2007). Anti-inflammatory effects of phosphatidylcholine. The Journal of Biological Chemistry, 282(37), 27155-27164. PubMed doi:10.1074/jbc.M704408200
45. Troiano, R.P. (2007). Large-scale applications of accelerometers: new frontiers and new questions. Medicine and Science in Sports and Exercise, 39(9), 1501. PubMed doi:10.1097/mss.0b013e318150d42e
46. Wallner, S., & Schmitz, G. (2011). Plasmalogens the neglected regulatory and scavenging lipid species. Chemistry and Physics of Lipids, 164(6), 573-589. PubMed doi:10.1016/j.chemphyslip.2011.06.008
47. Walsh, N.P., Gleeson, M., Shephard, R.J., Woods, J.A., Bishop, N.C., Fleshner, M., . . . Simon, P. (2011). Position statement. Part one: Immune function and exercise. Exercise Immunology Review, 17, 6-63. PubMed
48. Ward, M., McNulty, H., McPartlin, J., Strain, J.J., Weir, D.G., & Scott, J.M. (2001). Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. International Journal for Vitamin and Nutrition Research, 71(1), 82-86. PubMed doi:10.1024/0300-9831.71.1. 82