Genomic predictors of the maximal O2 uptake response to standardized exercise training programs

Journal of Applied Physiology

Volumn 110, Issue 5, 2011, Pages 1160-1170

  Bouchard, Claude ^a   Sarzynski, Mark A ^a   Rice, Treva K ^b   Kraus, William E ^c   Church, Timothy S ^a   Sung, Yun Ju ^b   Rao, D C ^b   Rankinen, Tuomo ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endurance training; High and low responders; Human variation; Trainability

Indexed keywords

PROTEOME;

ADOLESCENT; ADULT; AGED; ARTICLE; EXERCISE; FITNESS; GENETIC LINKAGE; GENETIC MARKER; GENETICS; GENOME; HUMAN; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; GENETIC LINKAGE; GENETIC MARKERS; GENOME; HUMANS; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PHYSICAL EXERTION; PHYSICAL FITNESS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEOME; YOUNG ADULT;

EID: 79956077552     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00973.2010     Document Type: Article

References (47)

1. Beermann ML, Ardelt M, Girgenrath M, Miller JB. Prdm1 (Blimp-1) and the expression of fast and slow myosin heavy chain isoforms during avian myogenesis in vitro. PLoS One 5: e9951, 2010.
2. Blair SN, Kohl HW 3rd, Barlow CE, Paffenbarger RS Jr, Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 273: 1093-1098, 1995.
3. Blair SN, Kampert JB, Kohl 3rd HW, Barlow CE, Macera CA, Paffenbarger RS Jr, Gibbons LW. Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA 276: 205-210, 1996. (Pubitemid 26235064)
4. Bouchard C, Dionne FT, Simoneau JA, Boulay MR. Genetics of aerobic and anaerobic performances. Exerc Sport Sci Rev 20: 27-58, 1992.
5. Bouchard C, Leon AS, Rao DC, Skinner JS, Wilmore JH, Gagnon J. The HERITAGE family study. Aims, design, and measurement protocol. Med Sci Sports Exerc 27: 721-729, 1995.
6. Bouchard C, Blair SN, Haskell WL. (editors). Physical Activity and Health. Champaign, IL: Human Kinetics, 2007.
7. 2max in the sedentary state: the HERITAGE family study. Med Sci Sports Exerc 30: 252-258, 1998. (Pubitemid 28095941)
8. 2max response to exercise training: results from the HERITAGE Family Study. J Appl Physiol 87: 1003-1008, 1999. (Pubitemid 29436977)
9. Bouchard C, Rankinen T, Chagnon YC, Rice T, Perusse L, Gagnon J, Borecki I, An P, Leon AS, Skinner JS, Wilmore JH, Province M, Rao DC. Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study. J Appl Physiol 88: 551-559, 2000. (Pubitemid 30097098)
10. Bouchard C, Rankinen T. Individual differences in response to regular physical activity. Med Sci Sports Exerc 33, Suppl 6: S446-S451, 2001. (Pubitemid 32524736)
11. Bouchard C, Rankinen T. Genetic determinants of physical performance. In: Olympic Textbook Science in Sport, edited by Maughan RJ. Hoboken, NJ: Wiley-Blackwell, 2009.
12. Bray M, Hagberg J, Perusse L, Rankinen T, Roth S, Wolfarth B, Bouchard C. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med Sci Sports Exer 41: 34-72, 2009.
13. Chiu CH, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 107: 813-822, 2001. (Pubitemid 32274034)
14. Church TS, Earnest CP, Skinner JS, Blair SN. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA 297: 2081-2091, 2007. (Pubitemid 46798166)
15. Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N. Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393: 377-381, 1998. (Pubitemid 28269712)
16. Duscha BD, Slentz CA, Johnson JL, Houmard JA, Bensimhon DR, Knetzger KJ, Kraus WE. Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease. Chest 128: 2788-2793, 2005. (Pubitemid 41507641)
17. Erikssen G, Liestol K, Bjornholt J, Thaulow E, Sandvik L, Erikseen J. Changes in physical fitness and changes in mortality. Lancet 352: 759-762, 1998. (Pubitemid 28404556)
18. Fletcher GF, Balady G, Blair SN, Blumenthal J, Caspersen C, Chaitman B, Epstein S, Sivarajan Froelicher ES, Froelicher VF, Pina IL, Pollock ML. Statement on exercise: benefits and recommendations for physical activity programs for all Americans. A statement for health professionals by the Committee on Exercise and Cardiac Rehabilitation of the Council on Clinical Cardiology, American Heart Association. Circulation 94: 857-862, 1996. (Pubitemid 26289247)
19. Fujihara C, Yamada S, Ozaki N, Takeshita N, Kawaki H, Takano-Yamamoto T, Murakami S. Role of mechanical stress-induced gulutamate signaling-associated molecules in cytodifferentiation of periodontal ligament cells. J Biol Chem 285: 28286-28297, 2010.
20. 2max to training in 60-71 yr olds. J Appl Physiol 71: 2004-2011, 1991.
21. Kokkinos P, Myers J, Faselis C, Panagiotakos DB, Pittaras A, Manolis A, Kokkinos JP, Karasik P, Greenberg M, Papademetriou V, Fletcher R. Exercise capacity and mortality in older men: a 20-year follow-up study. Circulation 122: 790-797, 2010.
22. Kraus WE, Torgan CE, Duscha BD, Norris J, Brown SA, Cobb FR, Bales CW, Annex BH, Samsa GP, Houmard JA, Slentz CA. Studies of a targeted risk reduction intervention through defined exercise (STRRIDE). Med Sci Sports Exerc 33: 1774-1784, 2001. (Pubitemid 32963883)
23. Lee DC, Sui X, Ortega FB, Kim YS, Church TS, Winett RA, Ekelund U, Katzmarzyk PT, Blair SN. Comparisons of leisure-time physical activity and cardiorespiratory fitness as predictors of all-cause mortality in men and women. Br J Sports Med; doi:10.1136/bjsm.2009.066209.
24. Lobo S, Wiczer BM, Bernlohr DA. Functional analysis of long-chain acyl-CoA synthetase 1 in 3T3-L1 adipocytes. J Biol Chem 284: 18347-56, 2009.
25. Loos RJ. Recent progress in the genetics of common obesity. Br J Clin Pharmacol 68: 811-829, 2009.
26. Lortie G, Simoneau JA, Hamel P, Boulay MR, Landry F, Bouchard C. Responses of maximal aerobic power and capacity to aerobic training. Int J Sports Med 5: 232-236, 1984. (Pubitemid 15200869)
27. Ma JZ, Payne TJ, Li MD. Significant association of glutamate receptor, ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European-and African-American smokers. Hum Genet 127: 503-512, 2010.
28. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 461: 747-753, 2009.
29. Martins GA, Cimmino L, Shapiro-Shelef M, Szabolcs M, Herron A, Magnusdottir E, Calame K. Transcriptional repressor Blimp-1 regulates T cell homeostasis and function. Nat Immunol 7: 457-465, 2006.
30. Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, Philippides G, Rocchini A; Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; Council on Nutrition, Physical Activity, and Metabolism; Interdisciplinary Council on Quality of Care and Outcomes Research. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 119: 3244-3262, 2009.
31. Morss GM, Jordan AN, Skinner JS, Dunn AL, Church TS, Earnest CP, Kampert JB, Jurca R, Blair SN. Dose response to exercise in women aged 45-75 yr (DREW): design and rationale. Med Sci Sports Exerc 36: 336-344, 2004. (Pubitemid 38177065)
32. Nie K, Zhang T, Allawi H, Gomez M, Liu Y, Chadburn A, Wang YL, Knowles DM, Tam W. Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas. A potential role of the microRNA Let-7. Am J Pathol 177: 1470-1479, 2010.
33. Ohinata Y, Payer B, O'Carroll D, Ancelin K, Ono Y, Sano M, Barton SC, Obukhanych T, Nussenzweig M, Tarakhovsky A, Saitou M, Surani MA. Blimp1 is a critical determinant of the germ cell lineage in mice. Nature 436: 207-213, 2005. (Pubitemid 41021265)
34. Phillips CM, Goumidi L, Bertrais S, Field MR, Cupples LA, Ordovas JM, Defoort C, Lovegrove JA, Drevon CA, Gibney MJ, Blaak EE, Kiec-Wilk B, Karlstrom B, Lopez-Miranda J, McManus R, Hercberg S, Lairon D, Planells R, Roche HM. Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res 51: 1793-1800, 2010.
35. Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee Report, 2008. Washington, DC: U. S. Department of Health and Human Services, 2008.
36. Prud'homme D, Bouchard C, Leblanc C, Landry F, Fontaine E. Sensitivity of maximal aerobic power to training is genotype dependent. Med Sci Sports Exerc 16: 489-493, 1984. (Pubitemid 15173498)
37. Rankinen T, Bouchard C. Genes, genetic heterogeneity, and exercise phenotypes. In: Molecular and Cellular Exercise Physiology, edited by Mooren FC, Volker K. Champaign, IL: Human Kinetics, 2005.
38. Skinner JS, Wilmore KM, Krasnoff JB, Jaskolski A, Jaskolska A, Gagnon J, Province MA, Leon AS, Rao DC, Wilmore JH, Bouchard C. Adaptation to a standardized training program and changes in fitness in a large, heterogeneous population: the HERITAGE Family Study. Med Sci Sports Exerc 32: 157-161, 2000. (Pubitemid 30056972)
39. Skinner JS, Jaskólski A, Jaskólska A, Krasnoff J, Gagnon J, Leon AS, Rao DC, Wilmore JH, Bouchard C; HERITAGE family study. Age, sex, race, initial fitness, and response to training: the HERITAGE Family Study. J Appl Physiol 90: 1770-1776, 2001. (Pubitemid 32336459)
40. Sui X, Hooker SP, Lee IM, Church TS, Colabianchi N, Lee CD, Blair SN. A prospective study of cardiorespiratory fitness and risk of type 2 diabetes in women. Diabetes Care 31: 550-555, 2008.
41. Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, Akerström T, Macdougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, van Loon LJ, Pedersen BK, Sundberg CJ, Wahlestedt C, Britton SL, Bouchard C. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol 108: 1487-96, 2010.
42. United States Department of Health and Human Services. Physical Activity and Health: a Report of the Surgeon General. Atlanta, GA: U. S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996.
43. Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RMvan Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Bragi Walters G, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI; investigators; GIANT Consortium MAGIC. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42: 579-589, 2010.
44. Wigginton JE, Cutler DJ, Abecasis GR. A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 76: 887-893, 2005. (Pubitemid 40563110)
45. Wilmore JH, Stanforth PR, Gagnon J, Rice T, Mandel S, Leon AS, Rao DC, Skinner JS, Bouchard C. Heart rate and blood pressure changes with endurance training: the HERITAGE Family Study. Med Sci Sports Exerc 33: 107-116, 2001. (Pubitemid 32064406)
46. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42: 565-569, 2010.
47. Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD. Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Am J Physiol Cell Physiol 285: C1356-C1366, 2003. (Pubitemid 37429610)