Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida

Immunobiology

Volumn 219, Issue 7, 2014, Pages 487-496

  Valiathan, Ranjini ^a   Deeb, Khaled ^a,b   Diamante, Marc ^a   Ashman, Margarita ^a,c   Sachdeva, Naresh ^a,d   Asthana, Deshratn ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b BARRY UNIVERSITY   (United States)

^c JACKSON MEMORIAL HOSPITAL   (United States)

^d POSTGRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Adolescents; Adults; Lymphocytes; Maturation subsets; Reference ranges

Indexed keywords

CD16 ANTIGEN; CD19 ANTIGEN; CD28 ANTIGEN; CD56 ANTIGEN; CD3 ANTIGEN; FC RECEPTOR;

ADOLESCENT; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CHILD; FEMALE; HUMAN; LYMPHOCYTE COUNT; MALE; MEMORY T LYMPHOCYTE; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; REFERENCE VALUE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UNITED STATES; CYTOLOGY; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD19; ANTIGENS, CD3; ANTIGENS, CD56; B-LYMPHOCYTES; CD4-CD8 RATIO; CHILD; FEMALE; FLORIDA; FLOW CYTOMETRY; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE COUNT; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; RECEPTORS, IGG; REFERENCE VALUES; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84900456903     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2014.02.010     Document Type: Article

References (73)

1. Al Qouzi A., Al Salamah A., Al Rasheed R., Al Musalam A., Al Khairy K., Kheir O., Al Ajaji S., Hajeer A.H. Immunophenotyping of peripheral blood lymphocytes in Saudi men. Clin. Diagn. Lab. Immunol. 2002, 9:279.
2. Anglaret X., Diagbouga S., Mortier E., Meda N., Verge-Valette V., Sylla-Koko F., Cousens S., Laruche G., Ledru E., Bonard D., Dabis F., Van de Perre P. CD4+ T-lymphocyte counts in HIV infection: are European standards applicable to African patients?. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1997, 14:361-370.
3. Azuma M., Phillips J.H., Lanier L.L. CD28- T lymphocytes. Antigenic and functional properties. J. Immunol. 1993, 150:1147.
4. Bisset L.R., Lung T.L., Kaelin M., Ludwig E., Dubs R.W. Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland. Eur. J. Haematol. 2004, 72:203.
5. Borthwick N.J., Bofill M., Gombert W.M., Akbar A.N., Medina E., Sagawa K., Lipman M.C., Johnson M.A., Janossy G. Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. AIDS 1994, 8:431.
6. Brinchmann J.E., Dobloug J.H., Heger B.H., Haaheim L.L., Sannes M., Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J. Infect. Dis. 1994, 169:730.
7. CDC HIV Surveillance Report. HIV diagnosis data are estimates from all 50 states, the District of Columbia, and 6 U.S. dependent areas 2013.
8. Chng W.J., Tan G.B., Kuperan P. Establishment of adult peripheral blood lymphocyte subset reference range for an Asian population by single-platform flow cytometry: influence of age, sex, and race and comparison with other published studies. Clin. Diagn. Lab. Immunol. 2004, 11:168.
9. Choi B.S., Park Y.K., Lee J.S. The CD28/HLA-DR expressions on CD4+ T but not CD8+ T cells are significant predictors for progression to AIDS. Clin. Exp. Immunol. 2002, 127:137.
10. Clement L.T., Yamashita N., Martin A.M. The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation. J. Immunol. 1988, 141:1464.
11. Cozon G., Greenland T., Revillard J.P. Profound CD4+ lymphocytopenia in the absence of HIV infection in a patient with visceral leishmaniasis. N. Engl. J. Med. 1990, 322:132.
12. Das B.R., Bhanushali A.A., Khadapkar R., Jeswani K.D., Bhavsar M., Dasgupta A. Reference ranges for lymphocyte subsets in adults from western India: influence of sex, age and method of enumeration. Indian J. Med. Sci. 2008, 62:397.
13. Daus H., Schwarze G., Radtke H. Reduced CD4+ count, infections, and immune thrombocytopenia without HIV infection. Lancet 1989, 2:559.
14. de Jong R., Brouwer M., Miedema F., van Lier R.A. Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation. J. Immunol. 1991, 146:2088.
15. de Wolf F., Spijkerman I., Schellekens P.T., Langendam M., Kuiken C., Bakker M., Roos M., Coutinho R., Miedema F., Goudsmit J. AIDS prognosis based on HIV-1 RNA, CD4+ T-cell count and function: markers with reciprocal predictive value over time after seroconversion. AIDS 1997, 11:1799.
16. Effros R.B., Allsopp R., Chiu C.P., Hausner M.A., Hirji K., Wang L., Harley C.B., Villeponteau B., West M.D., Giorgi J.V. Shortened telomeres in the expanded CD28- CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996, 10:F17.
17. Effros R.B., Dagarag M., Spaulding C., Man J. The role of CD8+ T-cell replicative senescence in human aging. Immunol. Rev. 2005, 205:147.
18. Fahey J.L., Schnelle J.F., Boscardin J., Thomas J.K., Gorre M.E., Aziz N., Sadeghi H., Nishanian P. Distinct categories of immunologic changes in frail elderly. Mech. Ageing Dev. 2000, 115:1.
19. Gautier V., Chanez P., Vendrell J.P., Pujol J.L., Lacoste J.Y., De Faucal H., Godard P., Michel F.B. Unexplained CD4-positive T-cell deficiency in non-HIV patients presenting as a Pneumocystis carinii pneumonia. Clin. Exp. Allergy 1991, 21:63.
20. Gemou-Engesaeth V., Fagerhol M.K., Toda M., Hamid Q., Halvorsen S., Groegaard J.B., Corrigan C.J. Expression of activation markers and cytokine mRNA by peripheral blood CD4 and CD8T cells in atopic and nonatopic childhood asthma: effect of inhaled glucocorticoid therapy. Pediatrics 2002, 109:E24.
21. Ginaldi L., De Martinis M., D'Ostilio A., Di Gennaro A., Marini L., Profeta V., Quaglino D. Activated naive and memory CD4+ and CD8+ subsets in different stages of HIV infection. Pathobiology 1997, 65:91.
22. Giorgi J.V., Hultin L.E., McKeating J.A., Johnson T.D., Owens B., Jacobson L.P., Shih R., Lewis J., Wiley D.J., Phair J.P., Wolinsky S.M., Detels R. Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J. Infect. Dis. 1999, 179:859.
23. Giorgi J.V., Lyles R.H., Matud J.L., Yamashita T.E., Mellors J.W., Hultin L.E., Jamieson B.D., Margolick J.B., Rinaldo C.R., Phair J.P., Detels R. Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J. Acquir. Immune Defic. Syndr. 2002, 29:346.
24. Hamann D., Baars P.A., Rep M.H., Hooibrink B., Kerkhof-Garde S.R., Klein M.R., van Lier R.A. Phenotypic and functional separation of memory and effector human CD8+ T cells. J. Exp. Med. 1997, 186:1407.
25. Hussain T., Abbas S., Khan M.A., Scrimshaw N.S. Lysine fortification of wheat flour improves selected indices of the nutritional status of predominantly cereal-eating families in Pakistan. Food Nutr. Bull. 2004, 25:114.
26. Janossy G., Jani I.V., Bradley N.J., Bikoue A., Pitfield T., Glencross D.K. Affordable CD4(+)-T-cell counting by flow cytometry: CD45 gating for volumetric analysis. Clin. Diagn. Lab. Immunol. 2002, 9:1085.
27. Jowitt S.N., Love E.M., Yin J.A., Pumphrey R.S. CD4 lymphocytopenia without HIV in patient with cryptococcal infection. Lancet 1991, 337:500.
28. Kammerer R., Iten A., Frei P.C., Burgisser P. Expansion of T cells negative for CD28 expression in HIV infection. Relation to activation markers and cell adhesion molecules, and correlation with prognostic markers. Med. Microbiol. Immunol. 1996, 185:19.
29. Kawiak J., Rokicka-Milewska R., Zeman K., Hoser G., Derulska G., Fornalczyk-Wachowska E., Gosk B., Kantorski J., Pacholska J., Tchorzewski H., et al. Peripheral blood leukocytes and lymphocyte subpopulations as determined by flow cytometric measurements in healthy children. Folia Histochem. Cytobiol. 1995, 33:33.
30. Klose N., Coulibaly B., Tebit D.M., Nauwelaers F., Spengler H.P., Kynast-Wolf G., Kouyate B., Krausslich H.G., Bohler T. Immunohematological reference values for healthy adults in Burkina Faso. Clin. Vaccine Immunol. 2007, 14:782.
31. Lebranchu Y., Thibault G., Degenne D., Bardos P. Abnormalities in CD4+ T lymphocyte subsets in patients with common variable immunodeficiency. Clin. Immunol. Immunopathol. 1991, 61:83.
32. Lee B.W., Yap H.K., Chew F.T., Quah T.C., Prabhakaran K., Chan G.S., Wong S.C., Seah C.C. Age- and sex-related changes in lymphocyte subpopulations of healthy Asian subjects: from birth to adulthood. Cytometry 1996, 26:8.
33. Levacher M., Hulstaert F., Tallet S., Ullery S., Pocidalo J.J., Bach B.A. The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value. Clin. Exp. Immunol. 1992, 90:376.
34. Levi F.A., Canon C., Blum J.P., Mechkouri M., Reinberg A., Mathe G. Circadian and/or circahemidian rhythms in nine lymphocyte-related variables from peripheral blood of healthy subjects. J. Immunol. 1985, 134:217.
35. Levi F.A., Canon C., Touitou Y., Reinberg A., Mathe G. Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects. J. Clin. Invest. 1988, 81:407.
36. Linsley P.S., Clark E.A., Ledbetter J.A. T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:5031.
37. Maecker H.T., Trotter J. Flow cytometry controls, instrument setup, and the determination of positivity. Cytometry A 2006, 69:1037.
38. Maini M.K., Gilson R.J., Chavda N., Gill S., Fakoya A., Ross E.J., Phillips A.N., Weller I.V. Reference ranges and sources of variability of CD4 counts in HIV-seronegative women and men. Genitourin. Med. 1996, 72:27.
39. Malone J.L., Simms T.E., Gray G.C., Wagner K.F., Burge J.R., Burke D.S. Sources of variability in repeated T-helper lymphocyte counts from human immunodeficiency virus type 1-infected patients: total lymphocyte count fluctuations and diurnal cycle are important. J. Acquir. Immune Defic. Syndr. 1990, 3:144.
40. Marcos A., Nova E., Montero A. Changes in the immune system are conditioned by nutrition. Eur. J. Clin. Nutr. 2003, 57(Suppl. 1):S66.
41. McCoy J.P., Keren D.F. Current practices in clinical flow cytometry. A practice survey by the American Society of Clinical Pathologists. Am. J. Clin. Pathol. 1999, 111:161.
42. McCoy J.P., Overton W.R. Quality control in flow cytometry for diagnostic pathology. II. A conspectus of reference ranges for lymphocyte immunophenotyping. Cytometry 1994, 18:129.
43. Messele T., Abdulkadir M., Fontanet A.L., Petros B., Hamann D., Koot M., Roos M.T., Schellekens P.T., Miedema F., Rinke de Wit T.F. Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts. Clin. Exp. Immunol. 1999, 115:443.
44. Monteiro J., Batliwalla F., Ostrer H., Gregersen P.K. Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+ CD8+ counterparts. J. Immunol. 1996, 156:3587.
45. Morbach H., Eichhorn E.M., Liese J.G., Girschick H.J. Reference values for B cell subpopulations from infancy to adulthood. Clin. Exp. Immunol. 2010, 162:271.
46. Murr C., Pilz S., Grammer T.B., Kleber M.E., Meinitzer A., Boehm B.O., Marz W., Fuchs D. Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. Clin. Chem. Lab. Med. 2012, 50:2205.
47. Murray S.E., Lallman H.R., Heard A.D., Rittenberg M.B., Stenzel-Poore M.P. A genetic model of stress displays decreased lymphocytes and impaired antibody responses without altered susceptibility to Streptococcus pneumoniae. J. Immunol. 2001, 167:691.
48. Oladepo D.K., Idigbe E.O., Audu R.A., Inyang U.S., Imade G.E., Philip A.O., Okafor G.O., Olaleye D., Mohammed S.B., Odunukwe N.N., Harry T.O., Edyong-Ekpa M., Idoko J., Musa A.Z., Adedeji A., Nasidi A., Ya'aba Y., Ibrahim K. Establishment of reference values of CD4 and CD8 lymphocyte subsets in healthy Nigerian adults. Clin. Vaccine Immunol. 2009, 16:1374.
49. Ostrowski S.R., Gerstoft J., Pedersen B.K., Ullum H. A low level of CD4+ CD28+ T cells is an independent predictor of high mortality in human immunodeficiency virus type 1-infected patients. J. Infect. Dis. 2003, 187:1726.
50. Perfetto S.P., Ambrozak D., Nguyen R., Chattopadhyay P., Roederer M. Quality assurance for polychromatic flow cytometry. Nat. Protoc. 2006, 1:1522.
51. Peters R.E., al-Ismail S. Immunophenotyping of normal lymphocytes. Clin. Lab. Haematol. 1994, 16:21.
52. PetitClerc C., Wilding P. International Federation of Clinical Chemistry (IFCC), Scientific Committee, Clinical Section. The theory of reference values. Part 2. Selection of individuals for the production of reference values. J. Clin. Chem. Clin. Biochem. 1984, 22:203.
53. Picker L.J., Treer J.R., Ferguson-Darnell B., Collins P.A., Buck D., Terstappen L.W. Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition. J. Immunol. 1993, 150:1105.
54. Rubin R.H., Carney W.P., Schooley R.T., Colvin R.B., Burton R.C., Hoffman R.A., Hansen W.P., Cosimi A.B., Russell P.S., Hirsch M.S. The effect of infection on T lymphocyte subpopulations: a preliminary report. Int. J. Immunopharmacol. 1981, 3:307.
55. Rudy B.J., Wilson C.M., Durako S., Moscicki A.B., Muenz L., Douglas S.D. Peripheral blood lymphocyte subsets in adolescents: a longitudinal analysis from the REACH project. Clin. Diagn. Lab. Immunol. 2002, 9:959.
56. Schnittman S.M., Lane H.C., Greenhouse J., Justement J.S., Baseler M., Fauci A.S. Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc. Natl. Acad. Sci. U. S. A. 1990, 87:6058.
57. Serra H.M., Krowka J.F., Ledbetter J.A., Pilarski L.M. Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event. J. Immunol. 1988, 140:1435.
58. Shahabuddin S., al Ayed I.H., el-Rad M.O., Qureshi M.I. Lymphocyte subset reference ranges in healthy Saudi Arabian children. Pediatr. Allergy Immunol. 1998, 9:44.
59. Slap G.B. Normal physiological and psychosocial growth in the adolescent. J. Adolesc. Health Care 1986, 7:13S.
60. Sleasman J.W., Aleixo L.F., Morton A., Skoda-Smith S., Goodenow M.M. CD4+ memory T cells are the predominant population of HIV-1-infected lymphocytes in neonates and children. AIDS 1996, 10:1477.
61. Tollerud D.J., Clark J.W., Brown L.M., Neuland C.Y., Pankiw-Trost L.K., Blattner W.A., Hoover R.N. The influence of age, race, and gender on peripheral blood mononuclear-cell subsets in healthy nonsmokers. J. Clin. Immunol. 1989, 9:214.
62. Tollerud D.J., Ildstad S.T., Brown L.M., Clark J.W., Blattner W.A., Mann D.L., Neuland C.Y., Pankiw-Trost L., Hoover R.N. T-cell subsets in healthy teenagers: transition to the adult phenotype. Clin. Immunol. Immunopathol. 1990, 56:88.
63. Trowbridge I.S., Thomas M.L. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu. Rev. Immunol. 1994, 12:85.
64. Tsegaye A., Messele T., Tilahun T., Hailu E., Sahlu T., Doorly R., Fontanet A.L., Rinke de Wit T.F. Immunohematological reference ranges for adult Ethiopians. Clin. Diagn. Lab. Immunol. 1999, 6:410.
65. Tugume S.B., Piwowar E.M., Lutalo T., Mugyenyi P.N., Grant R.M., Mangeni F.W., Pattishall K., Katongole-Mbidde E. Hematological reference ranges among healthy Ugandans. Clin. Diagn. Lab. Immunol. 1995, 2:233.
66. Uppal S.S., Verma S., Dhot P.S. Normal values of CD4 and CD8 lymphocyte subsets in healthy Indian adults and the effects of sex, age, ethnicity, and smoking. Cytom. B: Clin. Cytom. 2003, 52:32.
67. Vallejo A.N., Weyand C.M., Goronzy J.J. T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol. Med. 2004, 10:119.
68. Valleroy L.A., MacKellar D.A., Karon J.M., Rosen D.H., McFarland W., Shehan D.A., Stoyanoff S.R., LaLota M., Celentano D.D., Koblin B.A., Thiede H., Katz M.H., Torian L.V., Janssen R.S. HIV prevalence and associated risks in young men who have sex with men. Young Men's Survey Study Group. JAMA 2000, 284:198.
69. Vingerhoets J.H., Vanham G.L., Kestens L.L., Penne G.G., Colebunders R.L., Vandenbruaene M.J., Goeman J., Gigase P.L., De Boer M., Ceuppens J.L. Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+ T cells from HIV-infected subjects. Clin. Exp. Immunol. 1995, 100:425.
70. Vithayasai V., Sirisanthana T., Sakonwasun C., Suvanpiyasiri C. Flow cytometric analysis of T-lymphocytes subsets in adult Thais. Asian Pac. J. Allergy Immunol. 1997, 15:141.
71. Weng N.P., Akbar A.N., Goronzy J. CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 2009, 30:306.
72. Yaman A., Cetiner S., Kibar F., Tasova Y., Seydaoglu G., Dundar I.H. Reference ranges of lymphocyte subsets of healthy adults in Turkey. Med. Princ. Pract. 2005, 14:189.
73. Zhang Y., Wen H., Zhang Z.X., Cao L., Zhang Q., Lin R.Y., Lu X.M., Wang X., Ma X.D., Zhang J.P. Reference values of blood lymphocyte immunophenotype in the normal healthy adults of Ugyur and Han nationalities in Xinjiang. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006, 14:133.