TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF

Biochemical and Biophysical Research Communications

Volumn 447, Issue 4, 2014, Pages 689-695

  Ma, Bo ^a   Kang, Qianyan ^a   Qin, Li ^a   Cui, Lijun ^a   Pei, Cheng ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Connective tissue growth factor; Extracellular matrix; Gremlin; Human lens epithelial cells; Smad signaling pathway; Transforming growth factor 2

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CELL PROTEIN; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; GREMLIN; MESSENGER RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG; UVOMORULIN;

ARTICLE; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LENS EPITHELIUM; OCULAR FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

CONNECTIVE TISSUE GROWTH FACTOR; EXTRACELLULAR MATRIX; GREMLIN; HUMAN LENS EPITHELIAL CELLS; SMAD SIGNALING PATHWAY; TRANSFORMING GROWTH FACTOR Β2;

ACTINS; CADHERINS; CAPSULE OPACIFICATION; CELL TRANSDIFFERENTIATION; COLLAGEN TYPE I; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX; FIBRONECTINS; FIBROSIS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; POSTERIOR CAPSULE OF THE LENS; POSTOPERATIVE COMPLICATIONS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84900442122     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.068     Document Type: Article

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