Discovery of the fibrinolysis inhibitor AZD6564, acting via interference of a protein-protein interaction

ACS Medicinal Chemistry Letters

Volumn 5, Issue 5, 2014, Pages 538-543

  Cheng, Leifeng ^a   Pettersen, Daniel ^a   Ohlsson, Bengt ^a   Schell, Peter ^a   Karle, Michael ^a   Evertsson, Emma ^a   Pahlén, Sara ^a   Jonforsen, Maria ^a   Plowright, Alleyn T ^a   Boström, Jonas ^a   Fex, Tomas ^a   Thelin, Anders ^a   Hilgendorf, Constanze ^a   Xue, Yafeng ^a   Wahlund, Göran ^a   Lindberg, Walter ^a   Larsson, Lars Olof ^a   Gustafsson, David ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Fibrinolysis; inhibitor; isoxazolone; plasminogen; protein protein interaction; tranexamic acid

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ANTIFIBRINOLYTIC AGENT; AZD 6564; CARBOXYLIC ACID; GAMMA-AMINOBUTYRIC ACID RECEPTOR A; LYSINE; PLASMIN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; BINDING SITE; BLOOD CLOT LYSIS; HUMAN; IC 50; IN VITRO STUDY; PERMEABILITY; PLASMA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

EID: 84900431273     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400526d     Document Type: Article

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