Crystal structure of the native plasminogen reveals an activation-resistant compact conformation

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 7, 2012, Pages 1385-1396

  Xue, Y ^a   Bodin, C ^a   Olsson, K ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Antifibrinolytics; Crystal structure; Fibrinolysis; Kringle domain; Lysine binding site; Plasminogen activation

Indexed keywords

ALPHA 2 ANTIPLASMIN; ANGIOSTATIN; LYSINE; PLASMIN INHIBITOR; PLASMINOGEN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVATION; KRINGLE DOMAIN; LIGAND BINDING; MOLECULAR INTERACTION; PLASMINOGEN ACTIVATION; PRIORITY JOURNAL; PROTEIN STRUCTURE;

CHROMATOGRAPHY, AFFINITY; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; PLASMINOGEN; PROTEIN CONFORMATION;

EID: 84863429651     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2012.04765.x     Document Type: Article

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