Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  De Vita, Serena ^a   Schneider, Rebekka K ^b   Garcia, Michael ^a   Wood, Jenna ^a   Gavillet, Mathilde ^a   Ebert, Benjamin L ^b   Gerbaulet, Alexander ^c   Roers, Axel ^c   Levine, Ross L ^d   Mullally, Ann ^b   Williams, David A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ENZYME; KIT PROTEIN; PROTEIN TYROSINE KINASE; TET2 PROTEIN; UNCLASSIFIED DRUG; AZACITIDINE; DASATINIB; DECITABINE; DNA BINDING PROTEIN; ENZYME INHIBITOR; ONCOPROTEIN; PYRIMIDINE DERIVATIVE; STEM CELL FACTOR RECEPTOR; TET2 PROTEIN, HUMAN; TET2 PROTEIN, MOUSE; THIAZOLE DERIVATIVE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; DISEASE ACTIVITY; EPIGENETICS; GENE; HUMAN; HUMAN TISSUE; KIT GENE; LOSS OF FUNCTION MUTATION; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PHENOTYPE; PROMOTER REGION; PROTEIN DETERMINATION; PROTEIN FUNCTION; STEM CELL; SYSTEMIC MASTOCYTOSIS; TET2 GENE; TRANSCRIPTION INITIATION; ANALOGS AND DERIVATIVES; ANIMAL; BONE MARROW CELL; CELL CULTURE; COMBINATION DRUG THERAPY; DISEASE MODEL; ESOPHAGUS; GENETICS; KNOCKOUT MOUSE; MAST CELL; MASTOCYTOSIS, SYSTEMIC; METABOLISM; MISSENSE MUTATION; PATHOLOGY; RNA INTERFERENCE; SKIN; STOMACH; TRANSGENIC MOUSE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; AZACITIDINE; BLOTTING, WESTERN; BONE MARROW CELLS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; DASATINIB; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; ESOPHAGUS; HUMANS; MAST CELLS; MASTOCYTOSIS, SYSTEMIC; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION, MISSENSE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES; RNA INTERFERENCE; SKIN; STOMACH; THIAZOLES;

EID: 84900425362     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096209     Document Type: Article

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