Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation

Science

Volumn 344, Issue 6185, 2014, Pages 760-764

  Shinohara, Hisaaki ^a   Behar, Marcelo ^b,c   Inoue, Kentaro ^a   Hiroshima, Michio ^d,e   Yasuda, Tomoharu ^a,h   Nagashima, Takeshi ^a,i   Kimura, Shuhei ^f   Sanjo, Hideki ^a,j   Maeda, Shiori ^a   Yumoto, Noriko ^a   Ki, Sewon ^a   Akira, Shizuo ^g   Sako, Yasushi ^e   Hoffmann, Alexander ^b,c   Kurosaki, Tomohiro ^a,g   Okada Hatakeyama, Mariko ^a  

^a Institute of Physical and Chemical Research   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d RIKEN Center for Biosystems Dynamics Research   (Japan)

^e RIKEN   (Japan)

^f TOTTORI UNIVERSITY   (Japan)

^g OSAKA UNIVERSITY   (Japan)

^h MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

ⁱ TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^j SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CARD CONTAINING MAGUK PROTEIN 1; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; PHOSPHOTRANSFERASE; SCAFFOLD PROTEIN; SERINE; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; GUANYLATE CYCLASE; I KAPPA B KINASE; LYMPHOCYTE ANTIGEN RECEPTOR; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE;

ENZYME ACTIVITY; MUTATION; NUMERICAL MODEL; PROTEIN; SIGNALING;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GENE MUTATION; MATHEMATICAL MODEL; MOUSE; NONHUMAN; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STIMULATION; AGONISTS; ANIMAL; B LYMPHOCYTE; CELL LINE; CHICKEN; FEEDBACK SYSTEM; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; CARD SIGNALING ADAPTOR PROTEINS; CELL LINE; CHICKENS; FEEDBACK, PHYSIOLOGICAL; GUANYLATE CYCLASE; I-KAPPA B KINASE; MAP KINASE KINASE KINASES; MICE; MICE, KNOCKOUT; MUTATION; NF-KAPPA B; PHOSPHORYLATION; RECEPTORS, ANTIGEN, B-CELL; SERINE; SIGNAL TRANSDUCTION;

EID: 84900406601     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1250020     Document Type: Article

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