Synthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agents

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Zhang, Heng ^a   Xu, Xiangqing ^b   Chen, Yin ^b   Qiu, Yinli ^b   Liu, Xin ^a   Liu, Bi Feng ^a   Zhang, Guisen ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Jiangsu Nhwa Pharmaceutical Corporation Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1,1 TRIFLUOROPROPAN 2 YL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 ETHOXYPHENYL]ACETATIC ACID; 1,1,1 TRIFLUOROPROPAN 2 YL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 METHOXYPHENYL]ACETATIC ACID; 2,2,2 TRIFLUOROETHYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 (2,2,2 TRIFLUOROETHOXY)PHENYL]ACETATIC ACID; 2,2,2 TRIFLUOROETHYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 (TRIFLUOROMETHOXY)PHENYL]ACETATIC ACID; 2,2,2 TRIFLUOROETHYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 ETHOXYPHENYL]ACETATIC ACID; 2,2,2 TRIFLUOROETHYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 METHOXYPHENYL]ACETATIC ACID; 3,3,3 TRIFLUOROPROPYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 ETHOXYPHENYL]ACETATIC ACID; 3,3,3 TRIFLUOROPROPYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 METHOXYPHENYL]ACETATIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; AZD 3043; ETHYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 (2,2,2 TRIFLUOROETHOXY)PHENYL]ACETATIC ACID; ETHYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 (TRIFLUOROMETHOXY)PHENYL]ACETATIC ACID; FLUORINE CONTAINING PHENYLACETIC ACID DERIVATIVE; HYPNOTIC SEDATIVE AGENT; PHENYLACETIC ACID DERIVATIVE; PROPANIDID; PROPOFOL; PROPYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 (2,2,2 TRIFLUOROETHOXY)PHENYL]ACETATIC ACID; PROPYL 2 [4 [2 (DIETHYLAMINO) 2 OXOETHOXY] 3 (TRIFLUOROMETHOXY)PHENYL]ACETATIC ACID; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; FLUORINE; PHENOL DERIVATIVE; PHENYL ACETATE;

ANESTHETIC RECOVERY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DETERMINATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROPHYSIOLOGY; EXPERIMENTAL MOUSE; EXPERIMENTAL RABBIT; EXPERIMENTAL RAT; GABAERGIC SYSTEM; LIGAND BINDING; MOUSE; NONHUMAN; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD BRAIN BARRIER; CHEMISTRY; HALF LIFE TIME; MALE; RABBIT; SPRAGUE DAWLEY RAT; TIME;

ACETATES; ANESTHESIA RECOVERY PERIOD; ANIMALS; BLOOD-BRAIN BARRIER; FLUORINE; HALF-LIFE; HYPNOTICS AND SEDATIVES; MALE; MICE; PHENOLS; PROPANIDID; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 84900399381     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096518     Document Type: Article

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