Novel mixed NOP/MOP agonist BU08070 alleviates pain and inhibits gastrointestinal motility in mouse models mimicking diarrhea-predominant irritable bowel syndrome symptoms

European Journal of Pharmacology

Volumn 736, Issue , 2014, Pages 63-69

  Sobczak, Marta ^a   Cami Kobeci, Gerta ^b   Sałaga, Maciej ^a   Husbands, Stephen M ^b   Fichna, Jakub ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b University of Bath   (United Kingdom)

Author keywords

Abdominal pain; Buprenorphine; Gastrointestinal motility; Irritable bowel syndrome; Mixed agonist

Indexed keywords

1 (1 CYCLOOCTYLMETHYL 3 HYDROXYMETHYL 4 PIPERIDYL) 3 ETHYL 1,3 DIHYDRO 2H BENZIMIDAZOL 2 ONE; BETA FUNALTREXAMINE; BU 08070; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; NOCICEPTIN RECEPTOR; NOCICEPTIN RECEPTOR AGONIST; UNCLASSIFIED DRUG; ALLYL ISOTHIOCYANATE; BU08070; BUPRENORPHINE; CASTOR OIL; NARCOTIC ANALGESIC AGENT; OPIATE RECEPTOR; VEGETABLE OIL;

ABDOMINAL PAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIARRHEAL ACTIVITY; ANTINOCICEPTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG DOSE COMPARISON; FECES ANALYSIS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CONTRACTION; IRRITABLE COLON; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; STOMACH EMPTYING; WRITHING TEST; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; CHEMICALLY INDUCED; COLON; DISEASE MODEL; DRUG EFFECTS; ILEUM; IRRITABLE BOWEL SYNDROME; MUSCLE CONTRACTION; MUSTARD; PHYSIOLOGY; SMOOTH MUSCLE;

ABDOMINAL PAIN; ANALGESICS, OPIOID; ANIMALS; BUPRENORPHINE; CASTOR OIL; COLON; DIARRHEA; DISEASE MODELS, ANIMAL; GASTRIC EMPTYING; GASTROINTESTINAL MOTILITY; ILEUM; IN VITRO TECHNIQUES; IRRITABLE BOWEL SYNDROME; MALE; MICE, INBRED BALB C; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSTARD PLANT; PLANT OILS; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU;

EID: 84900370249     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.04.038     Document Type: Article

References (29)

1. J.K. Anastasi, B. Capili, and M. Chang Managing irritable bowel syndrome Am. J. Nurs. 113 2013 42 52
2. M. Boom, M. Niesters, E. Sarton, L. Aarts, T.W. Smith, and A. Dahan Non-analgesic effects of opioids: opioid-induced respiratory depression Curr. Pharm. Des. 18 2012 5994 6004
3. G. Cami-Kobeci, W.E. Polgar, T.V. Khroyan, L. Toll, and S.M. Husbands Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine J. Med. Chem. 54 2011 6531 6537
4. T. Christoph, B. Kogel, K. Schiene, M. Meen, V.J. De, and E. Friderichs Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain Eur. J. Pharmacol. 507 2005 87 98 (Pubitemid 40126844)
5. A. Cowan, J.C. Doxey, and E.J. Harry The animal pharmacology of buprenorphine, an oripavine analgesic agent Br. J. Pharmacol. 60 1977 547 554 (Pubitemid 8149540)
6. A. Cowan, J.W. Lewis, and I.R. Macfarlane Agonist and antagonist properties of buprenorphine, a new antinociceptive agent Br. J. Pharmacol. 60 1977 537 545 (Pubitemid 8149539)
7. N. Dietis, R. Guerrini, G. Calo, S. Salvadori, D.J. Rowbotham, and D.G. Lambert Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile Br. J. Anaesth. 103 2009 38 49
8. N. Eijkelkamp, A. Kavelaars, S. Elsenbruch, M. Schedlowski, G. Holtmann, and C.J. Heijnen Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior Am. J. Physiol.: Gastrointest. Liver Physiol. 293 2007 G749 G757
9. J. Fashner, and A.C. Gitu Common gastrointestinal symptoms: irritable bowel syndrome FP Essent. 413 2013 16 23
10. J. Fichna, M. Dicay, S.A. Hirota, D. Traboulsi, J.A. Macdonald, A. Janecka, P.L. Beck, J.K. Zjawiony, W.K. MacNaughton, and M.A. Storr Differential effects of salvinorin A on endotoxin-induced hypermotility and neurogenic ion transport in mouse ileum Neurogastroenterol. Motil. 23 2011 583-e212
11. J. Fichna, R. Schicho, C.N. Andrews, M. Bashashati, M. Klompus, D.M. McKay, K.A. Sharkey, J.K. Zjawiony, A. Janecka, and M.A. Storr Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating kappa-opioid and cannabinoid receptors Neurogastroenterol. Motil. 21 2009 1326-e128
12. J. Fichna, A. Sibaev, M. Salaga, M. Sobczak, and M. Storr The cannabinoid-1 receptor inverse agonist taranabant reduces abdominal pain and increases intestinal transit in mice Neurogastroenterol. Motil. 25 2013 e550 e559
13. J. Fichna, and M.A. Storr Brain-gut interactions in IBS Front. Pharmacol. 3 2012 127
14. K. Gach, J.C. do-Rego, J. Fichna, M. Storr, D. Delbro, G. Toth, and A. Janecka Synthesis and biological evaluation of novel peripherally active morphiceptin analogs Peptides 31 2010 1617 1624
15. R.E. Johnson, P.J. Fudala, and R. Payne Buprenorphine: considerations for pain management J. Pain Symptom Manag. 29 2005 297 326 (Pubitemid 40386746)
16. E. Kamysz, M. Salaga, M. Sobczak, W. Kamysz, and J. Fichna Characterization of the effects of opiorphin and sialorphin and their analogs substituted in position 1 with pyroglutamic acid on motility in the mouse ileum J. Pept. Sci. 19 2013 166 172
17. T.V. Khroyan, W.E. Polgar, F. Jiang, N.T. Zaveri, and L. Toll Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists J. Pharmacol. Exp. Ther. 331 2009 946 953
18. J.M. Laird, L. Martinez-Caro, E. Garcia-Nicas, and F. Cervero A new model of visceral pain and referred hyperalgesia in the mouse Pain 92 2001 335 342 (Pubitemid 32480163)
19. M. Larauche, G. Gourcerol, M. Million, D.W. Adelson, and Y. Tache Repeated psychological stress-induced alterations of visceral sensitivity and colonic motor functions in mice: influence of surgery and postoperative single housing on visceromotor responses Stress 13 2010 343 354
20. A.P. Lin, and M.C. Ko The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability ACS Chem. Neurosci. 4 2013 214 224
21. K. Lutfy, S. Eitan, C.D. Bryant, Y.C. Yang, N. Saliminejad, W. Walwyn, B.L. Kieffer, H. Takeshima, F.I. Carroll, N.T. Maidment, and C.J. Evans Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J. Neurosci. 23 2003 10331 10337 (Pubitemid 37444610)
22. J. Pergolizzi, A.M. Aloisi, A. Dahan, J. Filitz, R. Langford, R. Likar, S. Mercadante, B. Morlion, R.B. Raffa, R. Sabatowski, P. Sacerdote, L.M. Torres, and A.A. Weinbroum Current knowledge of buprenorphine and its unique pharmacological profile Pain Pract. 10 2010 428 450
23. P.W. Schiller Bi- or multifunctional opioid peptide drugs Life Sci. 86 2010 598 603
24. M. Sobczak, M. Salaga, M. Storr, and J. Fichna Nociceptin/orphanin FQ (NOP) receptors as novel potential target in the treatment of gastrointestinal diseases Curr. Drug Targets 14 2013 1203 1209
25. M. Sobczak, M. Salaga, M.A. Storr, and J. Fichna Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives J. Gastroenterol. 49 2014 24 45
26. B. Spagnolo, G. Calo, W.E. Polgar, F. Jiang, C.M. Olsen, I. Berzetei-Gurske, T.V. Khroyan, S.M. Husbands, J.W. Lewis, L. Toll, and N.T. Zaveri Activities of mixed NOP and mu-opioid receptor ligands Br. J. Pharmacol. 153 2008 609 619 (Pubitemid 351199024)
27. L. Toll, T.V. Khroyan, W.E. Polgar, F. Jiang, C. Olsen, and N.T. Zaveri Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications J. Pharmacol. Exp. Ther. 331 2009 954 964
28. G. Yu, Y.J. Yue, M.X. Cui, and Z.H. Gong Thienorphine is a potent long-acting partial opioid agonist: a comparative study with buprenorphine J. Pharmacol. Exp. Ther. 318 2006 282 287
29. P.L. Zhou, Y.L. Li, L.D. Yan, Z. Yong, G. Yu, H.J. Dong, H. Yan, R.B. Su, and Z.H. Gong Effect of thienorphine on intestinal transit and isolated guinea-pig ileum contraction World J. Gastroenterol. 19 2013 1444 1450