Electrophoretic particle guidance significantly enhances olfactory drug delivery: A feasibility study

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Xi, Jinxiang ^a   Si, Xiuhua A ^b   Gaide, Rachel ^b  

^a CENTRAL MICHIGAN UNIVERSITY   (United States)

^b CALVIN COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLOOD BRAIN BARRIER; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; ELECTRIC FIELD; ELECTRODE; ELECTROPHORESIS; FEASIBILITY STUDY; HUMAN; INHALER; MALE; MIDDLE AGED; NORMAL HUMAN; NOSE AIRFLOW; OLFACTORY DRUG DELIVERY; OLFACTORY EPITHELIUM;

ADMINISTRATION, INHALATION; ADMINISTRATION, INTRANASAL; ALGORITHMS; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS; FEASIBILITY STUDIES; HUMANS; MODELS, BIOLOGICAL; NOSE; OLFACTORY PATHWAYS; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS;

EID: 84900318233     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086593     Document Type: Article

References (45)

1. Bagger M, Bechgaard E (2004) A microdialysis model to examine nasal drug delivery and olfactory absorption in rats using lidocaine hydrochloride as a model drug. Int J Pharm 269: 311-322. (Pubitemid 38045295)
2. Mancuso G, Barth E, Crivello P, Rugarli EI (2012) Alternative Splicing of Spg7, a Gene Involved in Hereditary Spastic Paraplegia, Encodes a Variant of Paraplegin Targeted to the Endoplasmic Reticulum. PLoS ONE 7: e36337.
3. Dahlem MA, Hadjikhani N (2009) Migraine Aura: Retracting Particle-Like Waves in Weakly Susceptible Cortex. PLoS ONE 4: e5007.
4. Misra A, Kher G (2012) Drug Delivery Systems from Nose to Brain. Curr Pharm Biotechnol 13: 2355-2379.
5. Mistry A, Stolnik S, Illum L (2009) Nanoparticles for direct nose-to-brain delivery of drugs. Int J Pharm 379: 146-157.
6. Alam S, Khan ZI, Mustafa G, Kumar M, Islam F, et al. (2012) Development and evaluation of thymoquinone-encapsulated chitosan nanoparticles for nose-to-brain targeting: a pharmacoscintigraphic study. Int J Nanomedicine 7: 5705-5718.
7. Hanson L, Frey W (2007) Strategies for Intranasal Delivery of Therapeutics for the Prevention and Treatment of NeuroAIDS. J Neuroimmune Pharmacol 2: 81-86.
8. Shi H, Kleinstreuer C, Zhang Z (2006) Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model. J Biomech Eng 128: 697-706. (Pubitemid 44622798)
9. Si X, Xi J, Kim J, Zhou Y, Zhong H (2013) Modeling of release position and ventilation effects on olfactory aerosol drug delivery. Respir Physiol Neurobiol 186: 22-32.
10. Turker S, Onur E, Ozer Y (2004) Nasal route and drug delivery systems. Pharm World Sci 26: 137-142. (Pubitemid 39012580)
11. Illum L (2002) Nasal drug delivery: new developments and strategies. Drug Discov Today 7: 1184-1189.
12. Xi J, Longest PW, Anderson PJ (2010) Respiratory Aerosol Dynamics with Applications to Pharmaceutical Drug Delivery. In: Fanun M, editor. Colloids in Drug Delivery: CRC Press. 501-526.
13. Hinds WC (1999) Aerosol Technology: Properties, Behavior, and Measurement of Airborne Particles. New York: John Wiley and Sons.
14. Chan TL, Lippmann M, Cohen V, Schlesinger RB (1978) Effect of electrostatic charges on particle deposition in a hollow cast of the human larynx-tracheobronchial tree. J Aerosol Sci 9: 463-468. (Pubitemid 9397608)
15. Cohen BS, Xiong JQ, Asgharian B, Ayres L (1995) Deposition of inhaled charged ultrafine particles in a simple tracheal model. J Aerosol Sci 26: 1149-1160.
16. Kwok PCL, Noakes T, Chan H-K (2008) Effect of moisture on the electrostatic charge properties of metered dose inhaler aerosols. J Aerosol Sci 39: 211-226.
17. Kwok PCL, Glover W, Chan HK (2005) Electrostatic charge characteristics of aerosols produced from metered dose inhalers. J Pharm Sci 94: 2789-2799. (Pubitemid 43273180)
18. Yu CP, Chandra K (1977) Precipitation of submicron charged particles in human lung airways. Bull Math Biol 39: 471-478. (Pubitemid 8136528)
19. Fry FA (1970) Charge distribution on polystyrene aerosols and deposition in the human nose. J Aerosol Sci 1: 135-146.
20. Karner S, Urbanetz NA (2011) The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders. J Aerosol Sci 42: 428-445.
21. Tao X, Zhang Q, Ling K, Chen Y, Yang W, et al. (2012) Effect of Pullulan Nanoparticle Surface Charges on HSA Complexation and Drug Release Behavior of HSA-Bound Nanoparticles. PLoS ONE 7: e49304.
22. Chen YK, Yu CP (1993) Particle deposition from duct flows by combined mechanisms. Aerosol Sci Technol 19: 389-395. (Pubitemid 23284696)
23. Guilmette RA, Wicks JD, Wolff RK (1989) Morphometry of human nasal airways in vivo using Magnetic Resonance Imaging. J Aerosol Med 2: 365-377.
24. Cheng KH, Cheng YS, Yeh HC, Swift DL (1995) Deposition of ultrafine aerosols in the head airways during natural breathing and during simulated breath-holding using replicate human upper airway casts. Aerosol Sci Technol 23: 465-474.
25. Kelly JT, Asgharian B, Kimbell JS, Wong B (2004) Particle depositon in human nasal airway replicas manufactured by different methds. Part I: Inertial regime particles. Aerosol Sci Technol 38: 1063-1071. (Pubitemid 40075750)
26. Schroeter JD, Kimbell JS, Asgharian B (2006) Analysis of particle deposition in the turbinate and olfacotry regions using a human nasal computational fluid dynamics model. J Aerosol Med 19: 301-313. (Pubitemid 44735388)
27. Xi J, Berlinski A, Zhou Y, Greenberg B, Ou X (2012) Breathing Resistance and Ultrafine Particle Deposition in Nasal-Laryngeal Airways of a Newborn, an Infant, a Child, and an Adult. Ann Biomed Eng 40: 2579-2595.
28. Geller DE (2005) Comparing clinical features of the nebulizer, metered-dose inhaler, and dry powder inhaler. Respir Care 50: 1313-1321; discussion 1321-1312.
29. Covert D, Wiedensohler A, Russell L (1997) Particle charging and transmission efficiencies of aerosol charge neutralizers. Aerosol Sci Technol 27: 206-214. (Pubitemid 27327927)
30. Zeng Y, von Klitzing R (2012) Scaling of layer spacing of charged particles under slit-pore confinement: an effect of concentration or of effective particle diameter? Journal of Physics-Condensed Matter 24.
31. Xi J, Longest PW (2008) Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach. Int J Heat Mass Transfer 51: 5562-5577.
32. Xi J, Longest PW (2007) Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway. Ann Biomed Eng 35: 560-581. (Pubitemid 46448162)
33. Morsi SA, Alexander AJ (1972) An investigation of particle trajectories in two-phase flow systems. J Fluid Mechanics 55(2): 193-208.
34. Xi J, Longest PW (2009) Characterization of submicrometer aerosol deposition in extrathoracic airways during nasal exhalation. Aerosol Sci Technol 43: 808-827.
35. Xi J, Longest PW (2007) Effects of oral airway geometry characteristics on the diffusional deposition of inhaled nanoparticles. ASME Journal of Biomechanical Engineering 130: 011008-011001-011016.
36. Cheng KH, Cheng YS, Yeh HC, Swift DL (1995) Deposition of ultrafine aerosols in the head airways during natural breathing and during simulated breath holding using replicate human upper airway casts. Aerosol Science and Technology 23: 465-474.
37. Cheng YS, Su YF, Yeh HC, Swift DL (1993) Deposition of Thoron progeny in human head airways. Aerosol Sci Technol 18: 359-375.
38. Ribeiro P, Si X (2012) Section 2: Electric and Magnetic Circuit. In: Beaty HW, Fink DG, editors. Standard Handbook for Electrical Engineering. 16 ed: McGraw Hill. 2.1-2.58.
39. Zhang L, Rabussay DP (2002) Clinical evaluation of safety and human tolerance of electrical sensation induced by electric fields with non-invasive electrodes. Bioelectrochemistry 56: 233-236. (Pubitemid 34497011)
40. Petitot F, Lestaevel P, Tourlonias E, Mazzucco C, Jacquinot S, et al. (2013) Inhalation of uranium nanoparticles: Respiratory tract deposition and translocation to secondary target organs in rats. Toxicol Lett 217: 217-225.
41. Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P (2013) Metal and Silicate Particles Including Nanoparticles Are Present in Electronic Cigarette Cartomizer Fluid and Aerosol. PLoS ONE 8: e57987.
42. Dhand R (2012) Aerosol Therapy in Patients Receiving Noninvasive Positive Pressure Ventilation. Journal of Aerosol Medicine and Pulmonary Drug Delivery 25: 63-78.
43. Willis LD, Berlinski A (2012) Survey of Aerosol Delivery Techniques to Spontaneously Breathing Tracheostomized Children. Respir Care 57: 1234-1241.
44. Nava S, Karakurt S, Rampulla C, Braschi A, Fanfulla F (2001) Salbutamol delivery during non-invasive mechanical ventilation in patients with chronic obstructive pulmonary disease: a randomized, controlled study. Intensive Care Med 27: 1627-1635. (Pubitemid 33027960)
45. Yaakov Y, Kerem E, Yahav Y, Rivlin J, Blau H, et al. (2007) Reproducibility of nasal potential difference measurements in cystic fibrosis. Chest 132: 1219-1226. (Pubitemid 47620996)