The long non-coding HOTAIR is modulated by cyclic stretch and WNT/β-CATENIN in human aortic valve cells and is a novel repressor of calcification genes

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Carrion, Katrina ^a   Dyo, Jeffrey ^a   Patel, Vishal ^a   Sasik, Roman ^b   Mohamed, Salah A ^c   Hardiman, Gary ^d,e   Nigam, Vishal ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e SAN DIEGO STATE UNIVERSITY   (United States)

^f RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; LONG UNTRANSLATED RNA; PROTEIN HOTAIR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; WNT PROTEIN; HOTAIR LONG UNTRANSLATED RNA, HUMAN;

AORTA VALVE CALCIFICATION; AORTA VALVE DISEASE; ARTICLE; BLOOD VESSEL CALCIFICATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; REPRESSOR GENE; RNA ISOLATION; SIGNAL TRANSDUCTION; AORTA VALVE; AORTA VALVE STENOSIS; CALCINOSIS; CELL CULTURE; CONGENITAL MALFORMATION; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; TRICUSPID VALVE; VALVULAR HEART DISEASE; WNT SIGNALING PATHWAY;

AORTIC VALVE; AORTIC VALVE STENOSIS; CALCINOSIS; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART VALVE DISEASES; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, LONG NONCODING; RNA, SMALL INTERFERING; STRESS, PHYSIOLOGICAL; TRICUSPID VALVE; WNT SIGNALING PATHWAY;

EID: 84900310934     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096577     Document Type: Article

References (47)

1. Association AH (2004) Heart Disease and Stroke Statistics-2004 Update; Association AH, editor. Dallas, Texas.
2. Freeman RV, Otto CM (2005) Spectrum of calcific aortic valve disease: pathogenesis, disease progression, and treatment strategies. Circulation 111: 3316-3326. (Pubitemid 40875006)
3. Ward C (2000) Clinical significance of the bicuspid aortic valve. Heart 83: 81-85.
4. Fedak PW, Verma S, David TE, Leask RL, Weisel RD, et al. (2002) Clinical and pathophysiological implications of a bicuspid aortic valve. Circulation 106: 900-904. (Pubitemid 34925320)
5. Beppu S, Suzuki S, Matsuda H, Ohmori F, Nagata S, et al. (1993) Rapidity of progression of aortic stenosis in patients with congenital bicuspid aortic valves. Am J Cardiol 71: 322-327. (Pubitemid 23053442)
6. Davies MJ, Treasure T, Parker DJ (1996) Demographic characteristics of patients undergoing aortic valve replacement for stenosis: relation to valve morphology. Heart 75: 174-178. (Pubitemid 26069841)
7. Robicsek F, Thubrikar MJ, Cook JW, Fowler B (2004) The congenitally bicuspid aortic valve: how does it function? Why does it fail? Ann Thorac Surg 77: 177-185. (Pubitemid 38130007)
8. Szeto K, Pastuszko P, del Alamo JC, Lasheras J, Nigam V (2013) Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves. World journal for pediatric & congenital heart surgery 4: 362-366.
9. Rajamannan NM, Subramaniam M, Rickard D, Stock SR, Donovan J, et al. (2003) Human aortic valve calcification is associated with an osteoblast phenotype. Circulation 107: 2181-2184. (Pubitemid 36547209)
10. Mohler ER, 3rd, Chawla MK, Chang AW, Vyavahare N, Levy RJ, et al. (1999) Identification and characterization of calcifying valve cells from human and canine aortic valves. J Heart Valve Dis 8: 254-260. (Pubitemid 29274326)
11. Nigam V, Srivastava D (2009) Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol.
12. Kaden JJ, Dempfle CE, Grobholz R, Tran HT, Kilic R, et al. (2003) Interleukin-1 beta promotes matrix metalloproteinase expression and cell proliferation in calcific aortic valve stenosis. Atherosclerosis 170: 205-211. (Pubitemid 37377791)
13. Kaden JJ, Dempfle CE, Grobholz R, Fischer CS, Vocke DC, et al. (2005) Inflammatory regulation of extracellular matrix remodeling in calcific aortic valve stenosis. Cardiovasc Pathol 14: 80-87. (Pubitemid 40381303)
14. Naito Y, Tsujino T, Wakabayashi K, Matsumoto M, Ohyanagi M, et al. (2010) Increased interleukin-18 expression in nonrheumatic aortic valve stenosis. Int J Cardiol 144: 260-263.
15. Edep ME, Shirani J, Wolf P, Brown DL (2000) Matrix metalloproteinase expression in nonrheumatic aortic stenosis. Cardiovasc Pathol 9: 281-286.
16. Soini Y, Satta J, Maatta M, Autio-Harmainen H (2001) Expression of MMP2, MMP9, MT1-MMP, TIMP1, and TIMP2 mRNA in valvular lesions of the heart. J Pathol 194: 225-231.
17. Satta J, Oiva J, Salo T, Eriksen H, Ohtonen P, et al. (2003) Evidence for an altered balance between matrix metalloproteinase-9 and its inhibitors in calcific aortic stenosis. Ann Thorac Surg 76: 681-688; discussion 688.
18. Fondard O, Detaint D, Iung B, Choqueux C, Adle-Biassette H, et al. (2005) Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors. Eur Heart J 26: 1333-1341. (Pubitemid 41435466)
19. Nigam V, Sievers H, Jensen B, Sier H, Simpson P, et al. (2010) Altered MicroRNAs in Bicuspid Aortic Valves: A Comparison between Stenotic and Insufficient Valves. J Heart Valve Disease.
20. Nigam V, Sievers HH, Jensen BC, Sier HA, Simpson PC, et al. (2010) Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves. The Journal of heart valve disease 19: 459-465.
21. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, et al. (2010) Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464: 1071-1076.
22. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, et al. (2011) Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol 18: 1243-1250.
23. Schiavo G, D'Anto V, Cantile M, Procino A, Di Giovanni S, et al. (2011) Deregulated HOX genes in ameloblastomas are located in physical contiguity to keratin genes. J Cell Biochem 112: 3206-3215.
24. Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, et al. (2011) Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res 71: 6320-6326.
25. Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, et al. (2012) HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene.
26. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, et al. (2007) Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell 129: 1311-1323. (Pubitemid 46962090)
27. Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, et al. (2010) Long noncoding RNA as modular scaffold of histone modification complexes. Science 329: 689-693.
28. Jian B, Jones PL, Li Q, Mohler ER, 3rd, Schoen FJ, et al. (2001) Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis. Am J Pathol 159: 321-327. (Pubitemid 33704217)
29. Clark-Greuel JN, Connolly JM, Sorichillo E, Narula NR, Rapoport HS, et al. (2007) Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. Ann Thorac Surg 83: 946-953. (Pubitemid 46328821)
30. Kaden JJ, Bickelhaupt S, Grobholz R, Vahl CF, Hagl S, et al. (2004) Expression of bone sialoprotein and bone morphogenetic protein-2 in calcific aortic stenosis. J Heart Valve Dis 13: 560-566.
31. Mathieu P, Voisine P, Pepin A, Shetty R, Savard N, et al. (2005) Calcification of human valve interstitial cells is dependent on alkaline phosphatase activity. J Heart Valve Dis 14: 353-357. (Pubitemid 47050748)
32. Caira FC, Stock SR, Gleason TG, McGee EC, Huang J, et al. (2006) Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol 47: 1707-1712.
33. Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC (2005) Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 112: I229-234. (Pubitemid 41266679)
34. Rajamannan NM (2012) Oxidative-mechanical stress signals stem cell niche mediated Lrp5 osteogenesis in eNOS(-/-) null mice. J Cell Biochem 113: 1623-1634.
35. Rajamannan NM, Subramaniam M, Stock SR, Stone NJ, Springett M, et al. (2005) Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve. Heart 91: 806-810. (Pubitemid 40769233)
36. Westendorf JJ, Kahler RA, Schroeder TM (2004) Wnt signaling in osteoblasts and bone diseases. Gene 341: 19-39. (Pubitemid 39335880)
37. Glass DA, 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, et al. (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8: 751-764. (Pubitemid 40585297)
38. Shao JS, Cheng SL, Pingsterhaus JM, Charlton-Kachigian N, Loewy AP, et al. (2005) Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals. J Clin Invest 115: 1210-1220. (Pubitemid 40629039)
39. Faverman L, Mikhaylova L, Malmquist J, Nurminskaya M (2008) Extracellular transglutaminase 2 activates beta-catenin signaling in calcifying vascular smooth muscle cells. FEBS Lett 582: 1552-1557.
40. Cheng SL, Shao JS, Halstead LR, Distelhorst K, Sierra O, et al. (2010) Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis. Circ Res 107: 271-282.
41. Jian B, Narula N, Li QY, Mohler ER, 3rd, Levy RJ (2003) Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis. Ann Thorac Surg 75: 457-465; discussion 465-456.
42. Osman L, Yacoub MH, Latif N, Amrani M, Chester AH (2006) Role of human valve interstitial cells in valve calcification and their response to atorvastatin. Circulation 114: I547-552. (Pubitemid 44297206)
43. Xie Y, Wang X, Story M (2009) Statistical methods of background correction for Illumina BeadArray data. Bioinformatics 25: 751-757.
44. Liu J, Wu X, Mitchell B, Kintner C, Ding S, et al. (2005) A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl 44: 1987-1990. (Pubitemid 40483016)
45. Lehmann S, Walther T, Kempfert J, Rastan A, Garbade J, et al. (2009) Mechanical strain and the aortic valve: influence on fibroblasts, extracellular matrix, and potential stenosis. Ann Thorac Surg 88: 1476-1483.
46. Ferdous Z, Jo H, Nerem RM (2011) Differences in valvular and vascular cell responses to strain in osteogenic media. Biomaterials 32: 2885-2893.
47. Thanassoulis G, Campbell CY, Owens DS, Smith JG, Smith AV, et al. (2013) Genetic associations with valvular calcification and aortic stenosis. The New England journal of medicine 368: 503-512.