The complement inhibitor CD59 regulates insulin secretion by modulating exocytotic events

Cell Metabolism

Volumn 19, Issue 5, 2014, Pages 883-890

  Krus, Ulrika ^a   King, Ben C ^b   Nagaraj, Vini ^a   Gandasi, Nikhil R ^c   Sjölander, Jonatan ^b   Buda, Pawel ^a   Garcia Vaz, Eliana ^a   Gomez, Maria F ^a   Ottosson Laakso, Emilia ^a   Storm, Petter ^a   Fex, Malin ^a   Vikman, Petter ^a   Zhang, Enming ^a   Barg, Sebastian ^c   Blom, Anna M ^b   Renström, Erik ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD59 ANTIGEN; PHOSPHOLIPASE C; SNARE PROTEIN; SYNAPTOBREVIN 2; SYNTAXIN 1; COMPLEMENT; GLUCOSE; INSULIN; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOLYSIS; ERYTHROCYTE; EXOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; INTRACELLULAR SPACE; LIPID RAFT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RNA INTERFERENCE; ANIMAL; BIOBREEDING RAT; CELL MEMBRANE; METABOLISM; MOUSE; PHYSIOLOGY; SECRETION (PROCESS); WISTAR RAT;

ANIMALS; ANTIGENS, CD59; CELL MEMBRANE; COMPLEMENT SYSTEM PROTEINS; DIABETES MELLITUS, TYPE 2; EXOCYTOSIS; GLUCOSE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE PROTEINS; MICE; RATS; RATS, INBRED BB; RATS, WISTAR; SYNTAXIN 1; VESICLE-ASSOCIATED MEMBRANE PROTEIN 2;

EID: 84900310298     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.03.001     Document Type: Article

References (25)

1. L. Akesson, T. Hawkins, R. Jensen, J.M. Fuller, N.E. Breslow, and A. Lernmark Decreased core temperature and increased beta(3)-adrenergic sensitivity in diabetes-prone BB rats Diabetes Technol. Ther. 9 2007 354 362
2. S. Anders, P. Pyl, and W. Huber HTSeq - A Python framework to work with high-throughput sequencing data 2014 Cold Spring Harbor Laboratory BioRxiv
3. A. Andoh, Y. Fujiyama, H. Sakumoto, H. Uchihara, T. Kimura, S. Koyama, and T. Bamba Detection of complement C3 and factor B gene expression in normal colorectal mucosa, adenomas and carcinomas Clin. Exp. Immunol. 111 1998 477 483
4. S. Barg, C.S. Olofsson, J. Schriever-Abeln, A. Wendt, S. Gebre-Medhin, E. Renström, and P. Rorsman Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells Neuron 33 2002 287 299
5. W. Bennet, A. Björkland, B. Sundberg, D. Brandhorst, M.D. Brendel, A. Richards, D.J. White, B. Nilsson, C.G. Groth, and O. Korsgren Expression of complement regulatory proteins on islets of Langerhans: a comparison between human islets and islets isolated from normal and hDAF transgenic pigs Transplantation 72 2001 312 319
6. J. Diana, L. Gahzarian, Y. Simoni, and A. Lehuen Innate immunity in type 1 diabetes Discov. Med. 11 2011 513 520
7. A. Dobin, C.A. Davis, F. Schlesinger, J. Drenkow, C. Zaleski, S. Jha, P. Batut, M. Chaisson, and T.R. Gingeras STAR: ultrafast universal RNA-seq aligner Bioinformatics 29 2013 15 21
8. M.Y. Donath, and S.E. Shoelson Type 2 diabetes as an inflammatory disease Nat. Rev. Immunol. 11 2011 98 107
9. C. Eggeling, C. Ringemann, R. Medda, G. Schwarzmann, K. Sandhoff, S. Polyakova, V.N. Belov, B. Hein, C. von Middendorff, A. Schönle, and S.W. Hell Direct observation of the nanoscale dynamics of membrane lipids in a living cell Nature 457 2009 1159 1162
10. S.H. Gerber, and T.C. Südhof Molecular determinants of regulated exocytosis Diabetes 51 Suppl 1 2002 S3 S11
11. P. Ghosh, R. Sahoo, A. Vaidya, S. Cantel, A. Kavishwar, A. Goldfine, N. Herring, L. Bry, M. Chorev, and J.A. Halperin A specific and sensitive assay for blood levels of glycated CD59: A novel biomarker for diabetes Am. J. Hematol. 88 2013 670 676
12. H.E. Hohmeier, H. Mulder, G. Chen, R. Henkel-Rieger, M. Prentki, and C.B. Newgard Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion Diabetes 49 2000 424 430
13. R. Jahn, T. Lang, and T.C. Südhof Membrane fusion Cell 112 2003 519 533
14. D.D. Kim, and W.C. Song Membrane complement regulatory proteins Clin. Immunol. 118 2006 127 136
15. F.C. Kimberley, B. Sivasankar, and B. Paul Morgan Alternative roles for CD59 Mol. Immunol. 44 2007 73 81
16. T. Lang SNARE proteins and 'membrane rafts' J. Physiol. 585 2007 693 698
17. T. Miwa, L. Zhou, M.A. Maldonado, M.P. Madaio, R.A. Eisenberg, and W.C. Song Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice J. Immunol. 189 2012 5434 5441
18. J.I. Odegaard, and A. Chawla Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis Science 339 2013 172 177
19. C.G. Ostenson, A. Khan, S.M. Abdel-Halim, A. Guenifi, K. Suzuki, Y. Goto, and S. Efendic Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat Diabetologia 36 1993 3 8
20. J.H. Passwell, G.F. Schreiner, R.A. Wetsel, and H.R. Colten Complement gene expression in hepatic and extrahepatic tissues of NZB and NZB x W (F1) mouse strains Immunology 71 1990 290 294
21. V.L. Reeves, C.M. Thomas, and E.J. Smart Lipid rafts, caveolae and GPI-linked proteins Adv. Exp. Med. Biol. 729 2012 3 13
22. D. Ricklin, G. Hajishengallis, K. Yang, and J.D. Lambris Complement: a key system for immune surveillance and homeostasis Nat. Immunol. 11 2010 785 797
23. M.G. Strainic, J. Liu, D. Huang, F. An, P.N. Lalli, N. Muqim, V.S. Shapiro, G.R. Dubyak, P.S. Heeger, and M.E. Medof Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells Immunity 28 2008 425 435
24. K.G. Suzuki, R.S. Kasai, K.M. Hirosawa, Y.L. Nemoto, M. Ishibashi, Y. Miwa, T.K. Fujiwara, and A. Kusumi Transient GPI-anchored protein homodimers are units for raft organization and function Nat. Chem. Biol. 8 2012 774 783
25. J. Wang, T. Takeuchi, S. Tanaka, S.K. Kubo, T. Kayo, D. Lu, K. Takata, A. Koizumi, and T. Izumi A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse J. Clin. Invest. 103 1999 27 37