Characterization of extended-spectrum betalactamase-producing klebsiella pneumoniae from Riyadh, Saudi Arabia

Journal of Chemotherapy

Volumn 26, Issue 3, 2014, Pages 139-145

  Al Qahtani, Ahmed A ^a   Al Agamy, Mohamed H ^b,c   Ali, Mohamed S ^c   Al Ahdal, Mohammad N ^a   Aljohi, Mohammad A ^d   Shibl, Atef M ^b  

^a KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

^c AL AZHAR UNIVERSITY   (Egypt)

^d KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

Beta lactam resistance; Class a beta lactamases; PFGE

Indexed keywords

AMIKACIN; AMOXICILLIN PLUS CLAVULANIC ACID; AZTREONAM; BETA LACTAMASE CTX M; BETA LACTAMASE SHV; BETA LACTAMASE TEM 1; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CIPROFLOXACIN; COLISTIN; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; PIPERACILLIN PLUS TAZOBACTAM; TIGECYCLINE; BETA LACTAMASE;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLACTX M GENE; BLASHV GENE; BLATEM GENE; CLONE; CONTROLLED STUDY; DISK DIFFUSION; DNA SEQUENCE; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING KLEBSIELLA PNEUMONIAE; GENE AMPLIFICATION; GENOTYPE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTIPLEX POLYMERASE CHAIN REACTION; NONHUMAN; PREVALENCE; PULSED FIELD GEL ELECTROPHORESIS; SAUDI ARABIA; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICROBIOLOGY; MULTIDRUG RESISTANCE; POLYMERASE CHAIN REACTION;

BETA-LACTAMASES; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; POLYMERASE CHAIN REACTION; SAUDI ARABIA;

EID: 84900307120     PISSN: 1120009X     EISSN: 19739478     Source Type: Journal    
DOI: 10.1179/1973947813Y.0000000124     Document Type: Article

References (29)

1. Mansouri S, Kalantar D, Asadollahi P, Taherikalani M, Emaneini M. Characterization of Klebsiella pneumoniae strains producing extended spectrum beta-lactamases and AMPC type beta-lactamases isolated from hospitalized patients in Kerman, Iran. Roum Arch Microbiol Immunol. 2012;71(2):81-6.
2. Knothe H, Shah P, Krcmery V, Antal M, Mitsuhashi S. Transferable resistance to cefotaxime, cefoxitin, cefamandole and cefuroxime in clinical isolates of Klebsiella pneumoniae and Serratia marcescens. Infection. 1983;11:315-7.
3. Paterson DL, Bonomo RA. Extended-spectrum b-lactamases: a clinical update. Clin Microbiol Rev. 2005;18:657-86.
4. Bradford PA. Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev. 2001;14(4): 933-51.
5. Lonchel CM, Melin P, Gangoué-Piéboji J, Assoumou MC, Boreux R, De Mol P. Extended-spectrum b-lactamase-producing Enterobacteriaceae in Cameroonian hospitals. Eur J Clin Microbiol Infect Dis. 2013;32(1):79-87.
6. Coque TM, Baquero F, Canton R. Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Euro Surveill. 2008;13(47):19044.
7. Pitout JD, Laupland KB. Extended-spectrum beta-lactamaseproducing Enterobacteriaceae: an emerging public-health concern. Lancet Infect Dis. 2008;8:159-66.
8. Al-Agamy MH, Shibl AM, Tawfik AF. Prevalence and molecular characterization of extended-spectrum b-lactamaseproducing Klebsiella pneumoniae in Riyadh, Saudi Arabia. Ann Saudi Med. 2009;29(4):253-7.
9. Ahmad S, Al-Juaid NF, Alenzi FQ, Mattar EH, Bakheet Oel-S. Prevalence, Antibiotic Susceptibility pattern and production of extended-spectrum beta-lactamases amongst clinical isolates of Klebsiella pneumoniae at Armed Forces Hospital in Saudi Arabia. J Coll Physicians Surg Pak. 2009;9(4):264-5.
10. Al-Agamy MH, Shibl AM, Tawfik AF, Elbannai AR. Klebsiella pneumoniae producing CTX-M-15 from neonatal intensive care unit in Saudi Arabia. Res J Microbiol. 2009;4(7):278-85.
11. Clinical and laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 2012; 7th ed. Approved standard M02-A11. CLSI, Wayne, PA.
12. Dallenne C, Da Costa A, Decré D, Favier C, Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother. 2010;65:490-5.
13. Woodford N, Fagan EJ, Ellington MJ. Multiplex PCR for rapid detection of genes encoding CTX-M extended spectrum b-lactamases. J Antimicrob Chemother. 2006;57:154-5.
14. Gautom RK. Rapid pulsed-field gel electrophoresis protocol for typing of Escherichia coli O157:H7 and other gram-negative organisms in 1 day. J Clin Microbiol. 1997;35(11):2977-80.
15. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33(9):2233-9.
16. Lee JC, Lee NY, Lee HC, Huang WH, Tsui KC, Chang CM, et al. Clinical characteristics of urosepsis caused by extendedspectrum beta-lactamase-producing Escherichia coli or Klebsiella pneumoniae and their emergence in the community. J Microbiol Immunol Infect. 2012;45:127-33.
17. Cantón R, Novais A, Valverde A, Machado E, Peixe L, Baquero F, et al. Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe. Clin Microbiol Infect. 2008;14(Suppl.1):144-53.
18. Villegas MV, Kattan JN, Quinteros MG, Casellas JM. Prevalence of extended-spectrum b-lactamases in South America. Clin Microbiol Infect. 2008;14:154-8.
19. Al Johani SM, Akhter J, Balkhy H, El-Saed A, Younan M, Memish Z. Prevalence of antimicrobial resistance among gramnegative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia. Ann Saudi Med. 2010;30(5):364-9.
20. Kader AA, Kumar A. Prevalence and antimicrobial susceptibility of extended-spectrum b-lactamase-producing Escherichia coli and Klebsiella pneumoniae in a general hospital. Ann Saudi Med. 2005;25(3):239-42.
21. Tawfik AF, Alswailem AM, Shibl AM, Al-Agamy MH. Prevalence and genetic characteristics of TEM, SHV, and CTX-M in clinical Klebsiella pneumoniae isolates from Saudi Arabia. Microb Drug Resist. 2011;17(3):383-8.
22. Bilal NE, Gedebou M. Clinical and community strains of Klebsiella pneumoniae: multiple and increasing rates of antibiotic resistance in Abha, Saudi Arabia. Br J Biomed Sci. 2001;57:185-91.
23. Feizabadi MM, Delfani S, Raji N, Majnooni A, Aligholi M, Shahcheraghi F, et al. Distribution of blaTEM, blaSHV, blaCTX-M genes among clinical isolates of Klebsiella pneumoniae at Labbafinejad Hospital, Tehran, Iran. Microb Drug Resist. 2010;16(1):49-53.
24. Bindayna K, Khanfar HS, Senok AC, Botta GA. Predominance of CTX-M genotype among extended spectrum beta lactamase isolates in a tertiary hospital in Saudi Arabia. Saudi Med J. 2010;31(8):859-63.
25. Shibl AM, Al-Agamy MH, Khubnani H, Senok AC, Tawfik AF, Livermore DM. High prevalence of acquired quinoloneresistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 b-lactamase. Diagn Microbiol Infect Dis. 2012;73(4):350-3.
26. Poirel L, Gniadkowski M, Nordmann P. Biochemical analysis of ceftazidime-hydrolyzing extended-spectrum b-lactamase CTX-M-15 and its structurally related b-lactamase CTX-M-3. J Antimicrob Chemother. 2002;50:1031-4.
27. Bonnet R, Recule C, Baraduc R, Chanal C, Sirot D, De Champs C. et al. Effect of D240G substitution in a novel ESBL CTX-M-27. J Antimicrob Chemother. 2003;52(1):29-35.
28. Alzahrani AJ, Akhtar N. Susceptibility patterns of extended spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae isolated in a teaching hospital. Pak J Med Res. 2005;44(2):64-7.
29. Eltahawy AT, Khalaf RM. Antibiotic resistance among gramnegative non-fermentative bacteria at a teaching hospital in Saudi Arabia. J Chemother. 2001;13:260-4.