High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase

Diagnostic Microbiology and Infectious Disease

Volumn 73, Issue 4, 2012, Pages 350-353

  Shibl, Atef M ^a,b   Al Agamy, Mohamed H ^a,c   Khubnani, Harish ^d   Senok, Abiola C ^b   Tawfik, Abdulkader F ^a   Livermore, David M ^e  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b ALFAISAL UNIVERSITY   (Saudi Arabia)

^c Al Azhar University   (Egypt)

^d Prince Salman Hospital   (Saudi Arabia)

^e UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

Aac(6') 1b cr; Ciprofloxacin; DNA gyrase; Qnr genes; Topoisomerase IV

Indexed keywords

AMIKACIN; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ASPARTIC ACID; AZTREONAM; BETA LACTAMASE CTX M; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CIPROFLOXACIN; GENTAMICIN; GLUTAMIC ACID; GLUTAMINE; IMIPENEM; ISOLEUCINE; LEUCINE; MEROPENEM; NALIDIXIC ACID; PHENYLALANINE; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SERINE; TIGECYCLINE; TYROSINE;

AAC(6') 1B CR GENE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BLA GENE; ENTEROBACTERIACEAE; ESCHERICHIA COLI; GENE DUPLICATION; GENE SEQUENCE; GYRA GENE; HOSPITAL; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PARC GENE; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; QEPA GENE; QNRA GENE; QNRB GENE; QNRS GENE; SAUDI ARABIA;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; GENES, BACTERIAL; HOSPITALS; HUMANS; MICROBIAL SENSITIVITY TESTS; QUINOLONES; SAUDI ARABIA;

EID: 84863780138     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2012.04.005     Document Type: Article

References (20)

1. Acar J.F., Goldstein F.W. Trends in bacterial resistance to fluoroquinolones. Clin Infect Dis 1997, 24:S67-S73.
2. Ahmed A.M., Shimamoto T. Molecular characterization of antimicrobial resistance in Gram-negative bacteria isolated from bovine mastitis in Egypt. Microbiol Immunol 2011, 55:318-327.
3. Al-Agamy M.H., Shibl A.M., Tawfik A.F. Prevalence and molecular characterization of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in Riyadh, Saudi Arabia. Ann Saudi Med 2009, 29(4):253-257.
4. Baraniak A., Fiett J., Hryniewicz W., Nordmann P., Gniadkowski M. Ceftazidime-hydrolysing CTX-M-15 extended-spectrum beta-lactamase (ESBL) in Poland. J Antimicrob Chemother 2002, 50(3):393-396.
5. Barguigua A., El Otmani F., Talmi M., Bourjilat F., Haouzane F., Zerouali K., et al. Characterization of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates from the community in Morocco. J Med Microbiol 2011, 60:1344-1352.
6. Cattoir V., Poirel L., Rotimi V. Multiplex PCR for detection of plasmid mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 2007, 60:394-397.
7. Dahmen S., Poirel L., Mansour W., Bouallègue O., Nordmann P. Prevalence of plasmid-mediated quinolone resistance determinants in Enterobacteriaceae from Tunisia. Clin Microbiol Infect 2010, 16(7):1019-1023.
8. Dallenne C., Da Costa A., Decré D., Favier C., Arlet G. Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae. J Antimicrob Chemother 2010, 65:490-495.
9. Griggs D.J., Gensberg K., Piddock L.J. Mutations in gyrA gene of quinolone-resistant Salmonella serotypes isolated from humans and animals. Antimicrob Agents Chemother 1996, 40:1009-1013.
10. Heisig P. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother 1996, 40(4):879-885.
11. Jacoby G.A., Gacharna N., Black T.A., Miller G.H., Hooper D.C. Temporal appearance of plasmid-mediated quinolone resistance genes. Antimicrob Agents Chemother 2009, 53:1665-1666.
12. Khanfar H.S., Bindayna K.M., Senok A.C., Botta G.A. Extended spectrum beta-lactamases (ESBL) in Escherichia coli and Klebsiella pneumoniae: trends in the hospital and community settings. J Infect Dev Ctries 2009, 3(4):295-299.
13. Ling T.K., Xiong J., Yu Y., Lee C.C., Ye H., Hawkey P.M. Multicenter antimicrobial susceptibility survey of Gram-negative bacteria isolated from patients with community-acquired infections in the People's Republic of China. Antimicrob Agents Chemother 2006, 50:374-378.
14. Park C.H., Robicsek A., Jacoby G.A., Sahm D., Hooper D.C. Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme. Antimicrob Agents Chemother 2006, 50:3953-3955.
15. Silva-Sanchez J., Barrios H., Reyna-Flores F., Bello-Diaz M., Sanchez-Perez A., Rojas T., et al. Prevalence and characterization of plasmid-mediated quinolone resistance genes in extended-spectrum β-lactamase-producing Enterobacteriaceae isolates in Mexico. Microb Drug Resist 2011, [Epub ahead of print].
16. Smet A., Van Nieuwerburgh F., Vandekerckhove T.T., Martel A., Deforce D., Butaye P., et al. Complete nucleotide sequence of CTX-M-15-plasmids from clinical Escherichia coli isolates: insertional events of transposons and insertion sequences. PLoS One 2010, 5(6):e11202.
17. Tawfik A.F., Alswailem A.M., Shibl A.M., Al-Agamy M.H. Prevalence and genetic characteristics of TEM, SHV, and CTX-M in clinical Klebsiella pneumoniae isolates from Saudi Arabia. Microb Drug Resist 2011, 17(3):383-388.
18. Walsh F., Rogers T.R. Comparison of plasmid-mediated quinolone resistance and extended spectrum β-lactamases in 3rd generation cephalosporin resistant Enterobacteriaceae from four Irish hospitals. J Med Microbiol 2011, [Epub ahead of print].
19. Woodford N., Fagan E.J., Ellington M.J. Multiplex PCR for rapid detection of genes encoding CTX-M extended spectrum β-lactamases. J Antimicrob Chemother 2006, 57:154-155.
20. Yamane K., Wachino J.I., Suzuki S., Arakawa Y. Plasmid-mediated qepA gene among Escherichia coli clinical isolates, Japan. Antimicrob Agents Chemother 2008, 52:1564-1566.