The Memory Aid study: Protocol for a randomized controlled clinical trial evaluating the effect of computer-based working memory training in elderly patients with mild cognitive impairment (MCI)

Trials

Volumn 15, Issue 1, 2014, Pages

  Flak, Marianne M ^a   Hernes, Susanne S ^a   Skranes, Jon ^a,b   Løhaugen, Gro C C ^a,b  

^a Section for Gastroenterology   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; PLACEBO;

APOLIPOPROTEIN E GENE; ARTICLE; ATTENTION; AUDITORY MEMORY; BEHAVIOR RATING INVENTORY OF EXECUTIVE FUNCTIONS ADULT VERSION; BEHAVIORAL ASSESSMENT OF THE DYSEXECUTIVE SYNDROME QUESTIONNAIRE; CALIFORNIA VERBAL LEARNING TEST SECOND EDITION; CLINICAL PROTOCOL; COGNITION; COGNITIVE THERAPY; COMPUTER BASED WORKING MEMORY TRAINING; COMPUTER PROGRAM; DELIS KAPLAN EXECUTIVE FUNCTION SYSTEM; DIFFUSION TENSOR IMAGING; EXECUTIVE FUNCTION; FOLLOW UP; GENE; HUMAN; LMX1A GENE; MAJOR CLINICAL STUDY; MILD COGNITIVE IMPAIRMENT; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; PSYCHOLOGIC ASSESSMENT; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL (TOPIC); VISUAL MEMORY; WECHSLER INTELLIGENCE SCALE; WECHSLER MEMORY SCALE; WORKING MEMORY; AGE; AGING; COMPUTER ASSISTED THERAPY; CONTROLLED STUDY; MEMORY; METHODOLOGY; NORWAY; NUCLEAR MAGNETIC RESONANCE IMAGING; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT OUTCOME;

AGE FACTORS; AGING; CLINICAL PROTOCOLS; COGNITION; HUMANS; MAGNETIC RESONANCE IMAGING; MEMORY; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS; NORWAY; RESEARCH DESIGN; THERAPY, COMPUTER-ASSISTED; TIME FACTORS; TREATMENT OUTCOME;

EID: 84900026192     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/1745-6215-15-156     Document Type: Article

References (50)

1. Petersen RC, Negash S. Mild cognitive impairment: an overview. CNS Spectr 2008, 13(1):45-53.
2. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999, 56(3):303-308. 10.1001/archneur.56.3.303, 10190820.
3. Saunders NL, Summers MJ. Attention and working memory deficits in mild cognitive impairment. J Clin Exp Neuropsychol 2010, 32(4):350-357. 10.1080/13803390903042379, 19787522.
4. Baddeley A. Working memory: looking back and looking forward. Nat Rev Neurosci 2003, 4(10):829-839. 10.1038/nrn1201, 14523382.
5. Baddeley AD, Hitch GJL. Working memory. The psychology of learning and motivation: Advances in research and theory, Volume 8 1974, 47-89. New York: Academic, Bower GA.
6. Fry AF, Hale S. Relationships among processing speed, working memory, and fluid intelligence in children. Biol Psychol 2000, 54(1-3):1-34.
7. Salthouse TA. Mental exercise and mental aging: evaluating the validity of the "Use it or lose it" hypothesis. Perspect Psychol Sci 2006, 1:68-87.
8. Sitzer DI, Twamley EW, Jeste DV. Cognitive training in Alzheimer's disease: a meta-analysis of the literature. Acta Psychiatr Scand 2006, 114(2):75-90. 10.1111/j.1600-0447.2006.00789.x, 16836595.
9. Jolles DD, Crone EA. Training the developing brain: a neurocognitive perspective. Front Hum Neurosci 2012, 6:76. 3321411, 22509161.
10. Klingberg T. Training and plasticity of working memory. Trends Cogn Sci 2010, 14(7):317-324. 10.1016/j.tics.2010.05.002, 20630350.
11. Klingberg T. Development of a superior frontal-intraparietal network for visuo-spatial working memory. Neuropsychologia 2006, 44(11):2171-2177. 10.1016/j.neuropsychologia.2005.11.019, 16405923.
12. Engvig A, Fjell AM, Westlye ET, Moberget T, Sundseth T, Larsen VA, Walhovd KB. Effects of memory training on cortical thickness in the elderly. Neuroimage 2010, 52(4):1667-1676. 10.1016/j.neuroimage.2010.05.041, 20580844.
13. Takeuchi H, Sekiguchi A, Taki Y, Yokoyama S, Yomogida Y, Komuro N, Yamanouchi T, Suzuki S, Kawashima R. Training of working memory impacts structural connectivity. J Neurosci 2010, 30(9):3297-3303. 10.1523/JNEUROSCI.4611-09.2010, 20203189.
14. Takeuchi H, Taki Y, Hashizume H, Sassa Y, Nagase T, Nouchi R, Kawashima R. Effects of training of processing speed on neural systems. J Neurosci 2011, 31(34):12139-12148. 10.1523/JNEUROSCI.2948-11.2011, 21865456.
15. Johansson B, Tornmalm M. Working memory training for patients with acquired brain injury: effects in daily life. Scand J Occup Ther 2012, 19(2):176-183. 10.3109/11038128.2011.603352, 21843045.
16. Stott J, Spector A. A review of the effectiveness of memory interventions in mild cognitive impairment (MCI). Int Psychogeriatr 2011, 23(4):526-538. 10.1017/S1041610210001973, 20946704.
17. Thorell LB, Lindqvist S, Bergman Nutley S, Bohlin G, Klingberg T. Training and transfer effects of executive functions in preschool children. Dev Sci 2009, 12(1):106-113. 10.1111/j.1467-7687.2008.00745.x, 19120418.
18. Bergman Nutley S, Söderqvist S, Bryde S, Thorell LB, Humphreys K, Klingberg T. Gains in fluid intelligence after training non-verbal reasoning in 4-year-old children: a controlled, randomized study. Dev Sci 2011, 14(3):591-601. 10.1111/j.1467-7687.2010.01022.x, 21477197.
19. Gibson BS, Gondoli DM, Johnson AC, Steeger CM, Dobrzenski BA, Morrissey RA. Component analysis of verbal versus spatial working memory training in adolescents with ADHD: a randomized, controlled trial. Child Neuropsychol 2011, 17(6):546-563. 10.1080/09297049.2010.551186, 21390920.
20. Roughan L, Hadwin JA. The impact of working memory training in young people with social, emotional and behavioural difficulties. Learn Individ Differ 2011, 21(6):759-764.
21. Diamond A, Lee K. Interventions shown to aid executive function development in children 4 to 12 years old. Science 2011, 333(6045):959-964. 10.1126/science.1204529, 3159917, 21852486.
22. Løhaugen GCC, Antonsen I, Håberg A, Gramstad A, Vik T, Brubakk AM, Skranes J. Computerized working memory training improves function in adolescents born at extremely low birth weight. J Pediatr 2011, 158(4):555-U56. 10.1016/j.jpeds.2010.09.060, 21130467.
23. Løhaugen GCC, Gramstad A, Evensen KA, Martinussen M, Lindqvist S, Indredavik M, Vik T, Brubakk AM, Skranes J. Cognitive profile in young adults born preterm at very low birthweight. Dev Med Child Neurol 2010, 52(12):1133-1138. 10.1111/j.1469-8749.2010.03743.x, 21175467.
24. Dahlin KIE. Effects of working memory training on reading in children with special needs. Read Writ 2011, 24(4):479-491.
25. Holmes J, Place M, Dunning DL, Hilton KA, Elliott JG. Working memory deficits can be overcome: impacts of training and medication on working memory in children with ADHD. Appl Cogn Psychol 2010, 24(6):827-836.
26. Kronenberger WG, Pisoni DB, Henning SC, Colson BG, Hazzard LM. Working memory training for children with cochlear implants: a pilot study. J Speech Lang Hearing Res 2011, 54(4):1182-1196.
27. Lundqvist A, Grundström K, Samuelsson K, Rönnberg J. Computerized training of working memory in a group of patients suffering from acquired brain injury. Brain Inj 2010, 24(10):1173-1183. 10.3109/02699052.2010.498007, 20715888.
28. Mezzacappa E, Buckner JC. Working memory training for children with attention problems or hyperactivity: a school-based pilot study. Sch Ment Heal 2010, 2(8):202-208.
29. Klingberg T, Forssberg H, Westerberg H. Training of working memory in children with ADHD. J Clin Exp Neuropsychol 2002, 24(6):781-791. 10.1076/jcen.24.6.781.8395, 12424652.
30. Olesen PJ, Westerberg H, Klingberg T. Increased prefrontal and parietal activity after training of working memory. Nat Neurosci 2004, 7(1):75-79. 10.1038/nn1165, 14699419.
31. Westerberg H, Klingberg T. Changes in cortical activity after training of working memory-a single-subject analysis. Physiol Behav 2007, 92(1-2):186-192.
32. Westerberg H, Jacobaeus H, Hirvikoski T, Clevberger P, Ostensson ML, Bartfai A, Klingberg T. Computerized working memory training after stroke-a pilot study. Brain Inj 2007, 21(1):21-29. 10.1080/02699050601148726, 17364516.
33. Gates J, Sachdev PS, Fiatarone Singh MA, Valenzuela M. Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr 2011, 11:55. 10.1186/1471-2318-11-55, 3191477, 21942932.
34. Li H, Li J, Li N, Li B, Wang P, Zhou T. Cognitive intervention for persons with mild cognitive impairment: a meta-analysis. Ageing Res Rev 2011, 10(2):285-296. 10.1016/j.arr.2010.11.003, 21130185.
35. Bellander M, Brehmer Y, Westerberg H, Karlsson S, Fürth D, Bergman O, Eriksson E, Bäckman L. Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement. Neuropsychologia 2011, 49(7):1938-1942. 10.1016/j.neuropsychologia.2011.03.021, 21435346.
36. Soderqvist S, Bergman Nutley S, Peyrard-Janvid M, Matsson H, Humphreys K, Kere J, Klingberg T. Dopamine, working memory, and training induced plasticity: implications for developmental research. Dev Psychol 2012, 48(3):836-843.
37. Bäckman L, Nyberg L, Soveri A, Johansson J, Andersson M, Dahlin E, Neely AS, Virta J, Laine M, Rinne JO. Effects of working-memory training on striatal dopamine release. Science 2011, 333(6043):784.
38. McNab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T. Changes in cortical dopamine D1 receptor binding associated with cognitive training. Science 2009, 323(5915):800-802. 10.1126/science.1166102, 19197069.
39. Brehmer Y, Westerberg H, Bellander M, Fürth D, Karlsson S, Bäckman L. Working memory plasticity modulated by dopamine transporter genotype. Neurosci Lett 2009, 467(2):117-120. 10.1016/j.neulet.2009.10.018, 19819301.
40. Durstewitz D, Seamans JK. The computational role of dopamine D1 receptors in working memory. Neural Netw 2002, 15(4-6):561-572.
41. Schulz KF, Altman DG, Moher D, . CONSORT Group CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg 2011, 9(8):672-677. 10.1016/j.ijsu.2011.09.004, 22019563, CONSORT Group.
42. Boutron I, Moher D, Altman DG, Schulz K, Ravaud P, . for the CONSORT group Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Ann Intern Med 2008, 148:W-60-W-66. for the CONSORT group.
43. D'Esposito M, Postle BR, Rypma B. Prefrontal cortical contributions to working memory: evidence from event-related fMRI studies. Exp Brain Res 2000, 133(1):3-11. 10.1007/s002210000395, 10933205.
44. Rabin LA, Paré N, Saykin AJ, Brown MJ, Wishart HA, Flashman LA, Santulli RB. Differential memory test sensitivity for diagnosing amnestic mild cognitive impairment and predicting conversion to Alzheimer's disease. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 2009, 16(3):357-376. 10.1080/13825580902825220, 3114447, 19353345.
45. Lezak MD, Howieson DB, Loring DW. Neuropsychological assessment 2004, New York: Oxford University Press.
46. Klingberg T, Fernell E, Olesen PJ, Johnson M, Gustafsson P, Dahlström K, Gillberg CG, Forssberg H, Westerberg H. Computerized training of working memory in children with ADHD-a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 2005, 44(2):177-186. 10.1097/00004583-200502000-00010, 15689731.
47. Brehmer Y, Westerberg H, Backman L. Working-memory training in younger and older adults: training gains, transfer, and maintenance. Front Hum Neurosci 2012, 6:63. 3313479, 22470330.
48. University_of_Oxford. FMRIB Software Library, Release 4.1 University_of_Oxford. FMRIB Software Library, Release 4.1 2008, [cited 2012 01.09]; Available from: http://www.fmrib.ox.ac.uk/fsldownloads/, University_of_Oxford. FMRIB Software Library, Release 4.1.
49. Biomedical_Imaging, A.A.M.C Freesurfer image analysis suite (cited 01.05 2014). Available from: http://surfer.nmr.mgh.harvard.edu, Biomedical_Imaging, A.A.M.C.
50. Scarmeas N, Stern Y. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep 2004, 4(5):374-380. 10.1007/s11910-004-0084-7, 3026565, 15324603.