Preliminary evidence that allelic variation in the LMX1A gene influences training-related working memory improvement

Neuropsychologia

Volumn 49, Issue 7, 2011, Pages 1938-1942

  Bellander, Martin ^a   Brehmer, Yvonne ^a   Westerberg, Helena ^a   Karlsson, Sari ^a   Fürth, Daniel ^a   Bergman, Olle ^b   Eriksson, Elias ^b   Bäckman, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Dopamine; Gains; LMX1A gene; Midbrain; Striatum; Training; Working memory

Indexed keywords

ADULT; ALLELE; ARTICLE; ATTENTION; CONTROLLED STUDY; EPISODIC MEMORY; FEMALE; GENE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; LIM HOMEOBOX TRANSCRIPTION FACTOR 1ALPHA GENE; MALE; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; RESPONSE TIME; SINGLE NUCLEOTIDE POLYMORPHISM; SPATIAL MEMORY; VERBAL MEMORY; WORKING MEMORY;

ADULT; ALLELES; BRAIN CHEMISTRY; COGNITION; DATA INTERPRETATION, STATISTICAL; DNA; DOPAMINE; FEMALE; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; LEARNING; MALE; MEMORY, SHORT-TERM; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOMOTOR PERFORMANCE; REACTION TIME; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SERIAL LEARNING; SEX CHARACTERISTICS; STROOP TEST; VERBAL LEARNING; YOUNG ADULT;

EID: 79956155992     PISSN: 00283932     EISSN: 18733514     Source Type: Journal    
DOI: 10.1016/j.neuropsychologia.2011.03.021     Document Type: Article

References (57)

1. Alexander G.E., DeLong M.R., Strick P.L. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience 1986, 9(1):357-381.
2. Andersson E., Tryggvason U., Deng Q., Friling S., Alekseenko Z., Robert B., et al. Identification of intrinsic determinants of midbrain dopamine neurons. Cell 2006, 124(2):393-405.
3. Ando J., Ono Y., Wright M. Genetic structure of spatial and verbal working memory. Behavior Genetics 2001, 31(6):615-624.
4. Bäckman L., Lindenberger U., Li S., Nyberg L. Linking cognitive aging to alterations in dopamine neurotransmitter functioning: Recent data and future avenues. Neuroscience and Biobehavioral Reviews 2010, 34(5):670-677.
5. Bäckman L., Nyberg L., Lindenberger U., Li S.C., Farde L. The correlative triad among aging, dopamine, and cognition: Current status and future prospects. Neuroscience and Biobehavioral Reviews 2006, 30(6):791-807.
6. Bäckman L., Robins-Wahlin T.B., Lundin A., Ginovart N., Farde L. Cognitive deficits in Huntington's disease are predicted by dopaminergic PET markers and brain volumes. Brain 1997, 120(12):2207-2217.
7. Baddeley A. Working memory. Science 1992, 255(5044):556-559.
8. Baddeley A. The episodic buffer: A new component of working memory?. Trends in Cognitive Sciences 2000, 4(11):417-423.
9. Baltes P.B., Kliegl R. Further testing of limits of cognitive plasticity-Negative age-differences in a mnemonic skill are robust. Developmental Psychology 1992, 28(1):121-125.
10. Barnett J.H., Scoriels L., Munafò M.R. Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. Biological Psychiatry 2008, 64(2):137-144.
11. Barzilai A., Melamed E. Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease. Trends in Molecular Medicine 2003, 9(3):126-132.
12. Baunez C., Robbins T.W. Effects of dopamine depletion of the dorsal striatum and further interaction with subthalamic nucleus lesions in an attentional task in the rat. Neuroscience 1999, 92(4):1343-1356.
13. Bergman O., Håkansson A., Westberg L., Belin A.C., Sydow O., Olson L., et al. Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?. Journal of Neural Transmission 2009, 116(3):333-338.
14. Boussaoud D., Kermadi I. The primate striatum: Neuronal activity in relation to spatial attention versus motor preparation. European Journal of Neuroscience 1997, 9(10):2152-2168.
15. Brehmer Y., Li S.C., Müller V., von Oertzen T., Lindenberger U. Memory plasticity across the life span: Uncovering children's latent potential. Developmental Psychology 2007, 43(2):465-478.
16. Brehmer Y., Westerberg H., Bellander M., Fürth D., Karlsson S., Bäckman L. Working memory plasticity modulated by dopamine transporter genotype. Neuroscience Letters 2009, 467(2):117-120.
17. Brück A., Portin R., Lindell A., Laihinen A., Bergman J., Haaparanta M., et al. Positron emission tomography shows that impaired frontal lobe functioning in Parkinson's disease is related to dopaminergic hypofunction in the caudate nucleus. Neuroscience Letters 2001, 311(2):81-84.
18. Brück A., Aalto S., Nurmi E., Bergman J., Rinne J.O. Cortical 6-[18F]fluoro-l-dopa uptake and frontal cognitive functions in early Parkinson's disease. Neurobiology of Aging 2005, 26(6):891-898.
19. Cheesman A.L., Barker R.A., Lewis S.J.G., Robbins T.W., Owen A.M., Brooks D.J. Lateralisation of striatal function: Evidence from 18F-dopa PET in Parkinson's disease. Journal Neurology, Neurosurgery & Psychiatry 2005, 76(9):1204-1210.
20. Cropley V.L., Fujita M., Innis R.B., Nathan P.J. Molecular imaging of the dopaminergic system and its association with human cognitive function. Biological Psychiatry 2006, 59(10):898-907.
21. Dahlin E., Bäckman L., Stigsdotter Neely A., Nyberg L. Training of the executive component of working memory: Subcortical areas mediate transfer effects. Restorative Neurology and Neuroscience 2009, 27(5):405-419.
22. Dahlin E., Stigsdotter Neely A., Larsson A., Bäckman L., Nyberg L. Transfer of learning after updating training mediated by the striatum. Science 2008, 320(5882):1510-1512.
23. D'Esposito M. From cognitive to neural models of working memory. Philosophical Transactions of the Royal Society B: Biological Sciences 2007, 362(1481):761-772.
24. Dodrill C. Neuropsychological battery for epilepsy. Epilepsia 1978, 19(6):611-623.
25. Engle R., Tuholski S., Laughlin J., Conway A. Working memory, short-term memory, and general fluid intelligence: A latent-variable approach. Journal of Experimental Psychology: General 1999, 128(3):309-331.
26. Erixon-Lindroth N, Farde L., Robins Wahlin T.B., Sovago J., Halldin C., Bäckman L. The role of the striatal dopamine transporter in cognitive aging. Psychiatry Research: Neuroimaging 2005, 138(1):1-12.
27. Fischer H., Nyberg L., Karlsson S., Karlsson P., Brehmer Y., Rieckmann A., et al. Simulating neurocognitive aging: Effects of a dopaminergic antagonist on brain activity during working memory. Biological Psychiatry 2010, 67(6):575-580.
28. Friedman N., Miyake A., Young S., DeFries J., Corley R., Hewitt J. Individual differences in executive functions are almost entirely genetic in origin. Journal of Experimental Psychology: General 2008, 137(2):201-225.
29. Friling S., Andersson E., Thompson L.H., Jönsson M.E., Hebsgaard J.B., Nanou E., et al. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(18):7613-7618.
30. Gronwall D. Paced auditory serial-addition task-Measure of recovery from concussion. Perceptual & Motor Skills 1977, 44(2):367-373.
31. Karbach J., Kray J. How useful is executive control training? Age differences in near and far transfer of task-switching training. Developmental Science 2009, 12(6):978-990.
32. Kelly T.H., Foltin R.W., Fischman M.W. The effects of repeated amphetamine exposure on multiple measures of human behavior. Pharmacology, Biochemistry, and Behavior 1991, 38(2):417-426.
33. Kliegel R., Smith J., Baltes P.B. Testing-the-limits and the study of adult age-differences in cognitive plasticity of a mnemonic skill. Developmental Psychology 1989, 25(2):247-256.
34. Klingberg T. Training and plasticity of working memory. Trends in Cognitive Sciences 2010, 14(7):317-324.
35. Klingberg T., Fernell E., Olesen P.J., Johnson M., Gustafsson P., Dahlström K., et al. Computerized training of working memory in children with ADHD-A randomized, controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry 2005, 44(2):177.
36. Klingberg T., Forssberg H., Westerberg H. Training of working memory in children with ADHD. Journal of Clinical and Experimental Neuropsychology 2002, 24(6):781-791.
37. Landau S.M, Lal R., O'Neil J.P., Baker S., Jagust W.J. Striatal dopamine and working memory. Cerebral Cortex 2009, 19(2):445-454.
38. Leenders K.L., Salmon E.P., Tyrrell P., Perani D., Brooks D.J., Sager H., et al. The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson's disease. Archives of Neurology 1990, 47(12):1290-1298.
39. Lezak M.D. Neuropsychological assessment 1983, Oxford U.P., New York.
40. Li S.C., Schmiedek F., Huxhold O., Röcke C., Smith J., Lindenberger U. Working memory plasticity in old age: Practice gain, transfer, and maintenance. Psychology and Aging 2008, 23(4):731-742.
41. Luciana M., Collins P.F. Dopaminergic modulation of working memory for spatial but not object cues in normal humans. Journal of Cognitive Neuroscience 1997, 9(3):330-347.
42. Luciana M., Depue R.A., Arbisi P., Leon A. Facilitation of working memory in humans by a D2-dopamine receptor agonist. Journal of Cognitive Neuroscience 1992, 4(1):58-68.
43. Lövdén M., Bäckman L., Lindenberger U., Schaefer S., Schmiedek F. A theoretical framework for the study of adult cognitive plasticity. Psychological Bulletin 2010, 136(4):659-676.
44. Nakatani T., Kumai M., Mizuhara E., Minaki Y., Ono Y. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Developmental Biology 2010, 339(1):101-113.
45. Ono Y., Nakatani T., Sakamoto Y., Mizuhara E., Minaki Y., Kumai M., et al. Differences in neurogenic potential in floor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 2007, 134(17):3213-3225.
46. Payton A. The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009. Neuropsychology Review 2009, 19(4):451-477.
47. Ramaekers J.G., Louwerens J.W., Muntjewerff N.D., Milius H., de Bie A., Rosenzweig P., et al. Psychomotor, cognitive, extrapyramidal, and affective functions of healthy volunteers during treatment with an atypical (amisulpride) and a classic (haloperidol) antipsychotic. Journal of Clinical Psychopharmacology 1999, 19(3):209-221.
48. Raven J.C Standard progressive matrices sets A,B,C,D & E 1990, Oxford Psychologists Press.
49. Sanchez-Gonzalez M.A., Garcia-Cabezas M.A., Rico B., Cavada C. The primate thalamus is a key target for brain dopamine. Journal of Neuroscience 2005, 25(26):6076-6083.
50. Schmiedek F., Lövdén M., Lindenberger U. Hundred days of cognitive training enhance broad cognitive abilities in adulthood: Findings from the COGITO study. Frontiers in Aging Neuroscience 2010, 2(27).
51. Simon H., Taghzouti K., Le Moal M. Deficits in spatial-memory tasks following lesions of septal dopaminergic terminals in the rat. Behavioural Brain Research 1986, 19(1):7-16.
52. Smidt M.P., Burbach J.P.H. How to make a mesodiencephalic dopaminergic neuron. Nature Reviews Neuroscience 2007, 8(1):21-32.
53. Snow B.J., Tooyama I., McGeer E.G., Yamada T., Calne D.B., Takahashi H., et al. Human positron emission tomographic [18F]Fluorodopa studies correlate with dopamine cell counts and levels. Annals of Neurology 1993, 34(3):324-330.
54. Weidong Le, Shen Chen, Jankovic J. Etiopathogenesis of Parkinson disease: A new beginning?. The Neuroscientist 2008, 15(1):28-35.
55. Westerberg H., Hirvikoski T., Forssberg H., Klingberg T. Visuo-spatial working memory span: A sensitive measure of cognitive deficits in children with ADHD. Child Neuropsychology: A Journal on Normal and Abnormal Development in Childhood and Adolescence 2004, 10(3):155-161.
56. Williams G.V., Goldman-Rakic P.S. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 1995, 376(6541):572-575.
57. Wright M., De Geus E., Ando J., Luciano M., Posthuma D., Ono Y., et al. Genetics of cognition: Outline of a collaborative twin study. Twin Research: The Official Journal of the International Society for Twin Studies 2001, 4(1):48-56.