메뉴 건너뛰기




Volumn 53, Issue 10, 2014, Pages 1886-1895

High expression levels of the B cell chemoattractant CXCL13 in rheumatoid synovium are a marker of severe disease

Author keywords

B lymphocytes; Biomarkers; CXCL13; Rheumatoid arthritis; Synovium

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; CXCL13 CHEMOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 2; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

EID: 84900001764     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keu163     Document Type: Article
Times cited : (62)

References (50)
  • 1
    • 84857922958 scopus 로고    scopus 로고
    • The influence of ACPA status and characteristics on the course of RA
    • Willemze A, Trouw LA, Toes RE, Huizinga TW. The influence of ACPA status and characteristics on the course of RA. Nat Rev Rheumatol 2012;8:144-52.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 144-152
    • Willemze, A.1    Trouw, L.A.2    Toes, R.E.3    Huizinga, T.W.4
  • 4
    • 80052307481 scopus 로고    scopus 로고
    • Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis
    • de Hair MJ, Harty LC, Gerlag DM, et al. Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis. J Rheumatol 2011;38:2068-72.
    • (2011) J Rheumatol , vol.38 , pp. 2068-2072
    • de Hair, M.J.1    Harty, L.C.2    Gerlag, D.M.3
  • 5
    • 80755172249 scopus 로고    scopus 로고
    • Synovial tissue heterogeneity and peripheral blood biomarkers
    • Bugatti S, Manzo A, Bombardieri M, et al. Synovial tissue heterogeneity and peripheral blood biomarkers. Curr Rheumatol Rep 2011;13:440-8.
    • (2011) Curr Rheumatol Rep , vol.13 , pp. 440-448
    • Bugatti, S.1    Manzo, A.2    Bombardieri, M.3
  • 6
    • 79955564865 scopus 로고    scopus 로고
    • Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint
    • Meeuwisse CM, van der Linden MP, Rullmann TA, et al. Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint. Arthritis Rheum 2011;63:1265-73.
    • (2011) Arthritis Rheum , vol.63 , pp. 1265-1273
    • Meeuwisse, C.M.1    van der Linden, M.P.2    Rullmann, T.A.3
  • 7
    • 84856979170 scopus 로고    scopus 로고
    • Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological diseasemodifying anti-rheumatic drugs
    • Bugatti S, Manzo A, Benaglio F, et al. Serum levels of CXCL13 are associated with ultrasonographic synovitis and predict power Doppler persistence in early rheumatoid arthritis treated with non-biological diseasemodifying anti-rheumatic drugs. Arthritis Res Ther 2012; 14:R34.
    • (2012) Arthritis Res Ther , vol.14
    • Bugatti, S.1    Manzo, A.2    Benaglio, F.3
  • 8
    • 79952011168 scopus 로고    scopus 로고
    • CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis
    • Rosengren S, Wei N, Kalunian KC, Kavanaugh A, Boyle DL. CXCL13: a novel biomarker of B-cell return following rituximab treatment and synovitis in patients with rheumatoid arthritis. Rheumatology 2011;50:603-10.
    • (2011) Rheumatology , vol.50 , pp. 603-610
    • Rosengren, S.1    Wei, N.2    Kalunian, K.C.3    Kavanaugh, A.4    Boyle, D.L.5
  • 9
    • 0038240921 scopus 로고    scopus 로고
    • Ectopic germinal center formation in rheumatoid synovitis
    • Weyand CM, Goronzy JJ. Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci 2003; 987:140-9.
    • (2003) Ann N Y Acad Sci , vol.987 , pp. 140-149
    • Weyand, C.M.1    Goronzy, J.J.2
  • 10
    • 73249126744 scopus 로고    scopus 로고
    • Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling
    • Manzo A, Bombardieri M, Humby F, Pitzalis C. Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling. Immunol Rev 2010;233:267-85.
    • (2010) Immunol Rev , vol.233 , pp. 267-285
    • Manzo, A.1    Bombardieri, M.2    Humby, F.3    Pitzalis, C.4
  • 11
    • 84862186837 scopus 로고    scopus 로고
    • Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases
    • Corsiero E, Bombardieri M, Manzo A, et al. Role of lymphoid chemokines in the development of functional ectopic lymphoid structures in rheumatic autoimmune diseases. Immunol Lett 2012;145:62-7.
    • (2012) Immunol Lett , vol.145 , pp. 62-67
    • Corsiero, E.1    Bombardieri, M.2    Manzo, A.3
  • 13
    • 59249104722 scopus 로고    scopus 로고
    • Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium
    • Humby F, Bombardieri M, Manzo A et al. Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med 2009; 6:e1.
    • (2009) PLoS Med , vol.6
    • Humby, F.1    Bombardieri, M.2    Manzo, A.3
  • 14
    • 78650784468 scopus 로고    scopus 로고
    • V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis
    • Scheel T, Gursche A, Zacher J, Häupl T, Berek C. V-region gene analysis of locally defined synovial B and plasma cells reveals selected B cell expansion and accumulation of plasma cell clones in rheumatoid arthritis. Arthritis Rheum 2011;63:63-72.
    • (2011) Arthritis Rheum , vol.63 , pp. 63-72
    • Scheel, T.1    Gursche, A.2    Zacher, J.3    Häupl, T.4    Berek, C.5
  • 15
    • 0032536373 scopus 로고    scopus 로고
    • B cellattracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5
    • Legler DF, Loetscher M, Roos RS, et al. B cellattracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 1998;187: 655-60.
    • (1998) J Exp Med , vol.187 , pp. 655-660
    • Legler, D.F.1    Loetscher, M.2    Roos, R.S.3
  • 16
    • 80051630207 scopus 로고    scopus 로고
    • CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics
    • Sáez de Guinoa J, Barrio L, Mellado M, Carrasco YR. CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics. Blood 2011;118: 1560-9.
    • (2011) Blood , vol.118 , pp. 1560-1569
    • Sáez de Guinoa, J.1    Barrio, L.2    Mellado, M.3    Carrasco, Y.R.4
  • 17
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, Ohl L, Kremmer E, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000;192:1545-52.
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3
  • 18
    • 84862592738 scopus 로고    scopus 로고
    • Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells
    • León B, Ballesteros-Tato A, Browning JL, et al. Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells. Nat Immunol 2012;13: 681-90.
    • (2012) Nat Immunol , vol.13 , pp. 681-690
    • León, B.1    Ballesteros-Tato, A.2    Browning, J.L.3
  • 19
    • 0037211817 scopus 로고    scopus 로고
    • Human osteoblasts express functional CXC chemokine receptors 3 and activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release
    • Lisignoli G, Toneguzzi S, Piacentini A, et al. Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and beta-N-acetylhexosaminidase release. J Cell Physiol 2003;194:71-9.
    • (2003) J Cell Physiol , vol.194 , pp. 71-79
    • Lisignoli, G.1    Toneguzzi, S.2    Piacentini, A.3
  • 20
    • 77951249158 scopus 로고    scopus 로고
    • Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice
    • Pandruvada SN, Yuvaraj S, Liu X, et al. Role of CXC chemokine ligand 13 in oral squamous cell carcinoma associated osteolysis in athymic mice. Int J Cancer 2010; 126:2319-29.
    • (2010) Int J Cancer , vol.126 , pp. 2319-2329
    • Pandruvada, S.N.1    Yuvaraj, S.2    Liu, X.3
  • 21
    • 13444303845 scopus 로고    scopus 로고
    • CXCL13 neutralization reduces the severity of collagen-induced arthritis
    • Zheng B, Ozen Z, Zhang X, et al. CXCL13 neutralization reduces the severity of collagen-induced arthritis. Arthritis Rheum 2005;52:620-6.
    • (2005) Arthritis Rheum , vol.52 , pp. 620-626
    • Zheng, B.1    Ozen, Z.2    Zhang, X.3
  • 22
    • 35348861537 scopus 로고    scopus 로고
    • CXCR5-and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis
    • Wengner AM, Höpken UE, Petrow PK, et al. CXCR5-and CCR7-dependent lymphoid neogenesis in a murine model of chronic antigen-induced arthritis. Arthritis Rheum 2007; 56:3271-83.
    • (2007) Arthritis Rheum , vol.56 , pp. 3271-3283
    • Wengner, A.M.1    Höpken, U.E.2    Petrow, P.K.3
  • 23
  • 24
    • 84874418111 scopus 로고    scopus 로고
    • EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria
    • van der Heijde D, van der Helm-van Mil AH, Aletaha D, et al. EULAR definition of erosive disease in light of the 2010 ACR/EULAR rheumatoid arthritis classification criteria. Ann Rheum Dis 2013;72:479-81.
    • (2013) Ann Rheum Dis , vol.72 , pp. 479-481
    • van der Heijde, D.1    van der Helm-van Mil, A.H.2    Aletaha, D.3
  • 25
    • 0024604643 scopus 로고
    • Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis
    • van der Heijde DM, van Riel PL, Nuver-Zwart IH, Gribnau FW, vad de Putte LB. Effects of hydroxychloroquine and sulphasalazine on progression of joint damage in rheumatoid arthritis. Lancet 1989;1: 1036-8.
    • (1989) Lancet , vol.1 , pp. 1036-1038
    • van der Heijde, D.M.1    van Riel, P.L.2    Nuver-Zwart, I.H.3    Gribnau, F.W.4    vad de Putte, L.B.5
  • 26
    • 36448962702 scopus 로고    scopus 로고
    • Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure
    • Scirè CA, Epis O, Codullo V, et al. Immunohistological assessment of the synovial tissue in small joints in rheumatoid arthritis: validation of a minimally invasive ultrasound-guided synovial biopsy procedure. Arthritis Res Ther 2007;9:R101.
    • (2007) Arthritis Res Ther , vol.9
    • Scirè, C.A.1    Epis, O.2    Codullo, V.3
  • 27
    • 79951508967 scopus 로고    scopus 로고
    • Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials
    • van de Sande MG, Gerlag DM, Lodde BM et al. Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials. Ann Rheum Dis 2011;70:423-7.
    • (2011) Ann Rheum Dis , vol.70 , pp. 423-427
    • van de Sande, M.G.1    Gerlag, D.M.2    Lodde, B.M.3
  • 28
    • 36348958437 scopus 로고    scopus 로고
    • CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis
    • Manzo A, Bugatti S, Caporali R, et al. CCL21 expression pattern of human secondary lymphoid organ stroma is conserved in inflammatory lesions with lymphoid neogenesis. Am J Pathol 2007;171: 1549-62.
    • (2007) Am J Pathol , vol.171 , pp. 1549-1562
    • Manzo, A.1    Bugatti, S.2    Caporali, R.3
  • 29
    • 0037093852 scopus 로고    scopus 로고
    • Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium
    • Page G, Lebecque S, Miossec P. Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium. J Immunol 2002;168: 5333-41.
    • (2002) J Immunol , vol.168 , pp. 5333-5341
    • Page, G.1    Lebecque, S.2    Miossec, P.3
  • 30
    • 33846706571 scopus 로고    scopus 로고
    • Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration
    • Gregorio A, Gambini C, Gerloni V, et al. Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration. Rheumatology 2007;46:308-13.
    • (2007) Rheumatology , vol.46 , pp. 308-313
    • Gregorio, A.1    Gambini, C.2    Gerloni, V.3
  • 31
    • 0033637389 scopus 로고    scopus 로고
    • Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity
    • Baeten D, Demetter P, Cuvelier C, et al. Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity. Ann Rheum Dis 2000;59:945-53.
    • (2000) Ann Rheum Dis , vol.59 , pp. 945-953
    • Baeten, D.1    Demetter, P.2    Cuvelier, C.3
  • 32
    • 66149147550 scopus 로고    scopus 로고
    • Clinical significance of synovial lymphoid neogenesis and its reversal after antitumour necrosis factor alpha therapy in rheumatoid arthritis
    • Cañete JD, Celis R, Moll C, et al. Clinical significance of synovial lymphoid neogenesis and its reversal after antitumour necrosis factor alpha therapy in rheumatoid arthritis. Ann Rheum Dis 2009;68:751-6.
    • (2009) Ann Rheum Dis , vol.68 , pp. 751-756
    • Cañete, J.D.1    Celis, R.2    Moll, C.3
  • 33
    • 0031043106 scopus 로고    scopus 로고
    • Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity
    • Tak PP, Smeets TJ, Daha MR, et al. Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 1997;40: 217-25.
    • (1997) Arthritis Rheum , vol.40 , pp. 217-225
    • Tak, P.P.1    Smeets, T.J.2    Daha, M.R.3
  • 34
    • 22244477842 scopus 로고    scopus 로고
    • Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy
    • Baeten D, Kruithof E, De Rycke L, et al. Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy. Arthritis Res Ther 2005;7: R359-69.
    • (2005) Arthritis Res Ther , vol.7 , pp. R359-R369
    • Baeten, D.1    Kruithof, E.2    De Rycke, L.3
  • 35
    • 0033579821 scopus 로고    scopus 로고
    • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
    • Ngo VN, Korner H, Gunn MD, et al. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 1999;189:403-12.
    • (1999) J Exp Med , vol.189 , pp. 403-412
    • Ngo, V.N.1    Korner, H.2    Gunn, M.D.3
  • 36
    • 0037649055 scopus 로고    scopus 로고
    • Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung
    • Goya S, Matsuoka H, Mori M, et al. Sustained interleukin-6 signalling leads to the development of lymphoid organ-like structures in the lung. J Pathol 2003;200:82-7.
    • (2003) J Pathol , vol.200 , pp. 82-87
    • Goya, S.1    Matsuoka, H.2    Mori, M.3
  • 37
    • 79959379657 scopus 로고    scopus 로고
    • The development of inducible bronchus-associated lymphoid tissue depends on IL-17
    • Rangel-Moreno J, Carragher DM, de la Luz Garcia- Hernandez M, et al. The development of inducible bronchus- associated lymphoid tissue depends on IL-17. Nat Immunol 2011;12:639-46.
    • (2011) Nat Immunol , vol.12 , pp. 639-646
    • Rangel-Moreno, J.1    Carragher, D.M.2    de la Luz Garcia-Hernandez, M.3
  • 39
    • 45349084358 scopus 로고    scopus 로고
    • Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype
    • Thurlings RM, Wijbrandts CA, Mebius RE, et al. Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype. Arthritis Rheum 2008;58: 1582-9.
    • (2008) Arthritis Rheum , vol.58 , pp. 1582-1589
    • Thurlings, R.M.1    Wijbrandts, C.A.2    Mebius, R.E.3
  • 40
    • 47949114181 scopus 로고    scopus 로고
    • B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis
    • Cantaert T, Kolln J, Timmer T, et al. B lymphocyte autoimmunity in rheumatoid synovitis is independent of ectopic lymphoid neogenesis. J Immunol 2008;181:785-94.
    • (2008) J Immunol , vol.181 , pp. 785-794
    • Cantaert, T.1    Kolln, J.2    Timmer, T.3
  • 41
    • 84877587255 scopus 로고    scopus 로고
    • Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition
    • Amara K, Steen J, Murray F, et al. Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition. J Exp Med 2013;210:445-55.
    • (2013) J Exp Med , vol.210 , pp. 445-455
    • Amara, K.1    Steen, J.2    Murray, F.3
  • 42
    • 84855735731 scopus 로고    scopus 로고
    • Subclinical remodelling of draining lymph node structure in early and established rheumatoid arthritis assessed by power Doppler ultrasonography
    • Manzo A, Caporali R, Vitolo B, et al. Subclinical remodelling of draining lymph node structure in early and established rheumatoid arthritis assessed by power Doppler ultrasonography. Rheumatology 2011;50:1395-400.
    • (2011) Rheumatology , vol.50 , pp. 1395-1400
    • Manzo, A.1    Caporali, R.2    Vitolo, B.3
  • 43
    • 84871704718 scopus 로고    scopus 로고
    • Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective
    • Bugatti S, Manzo A, Caporali R, Montecucco C. Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective. Arthritis Res Ther 2012;14:229.
    • (2012) Arthritis Res Ther , vol.14 , pp. 229
    • Bugatti, S.1    Manzo, A.2    Caporali, R.3    Montecucco, C.4
  • 44
    • 53149103590 scopus 로고    scopus 로고
    • Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
    • Makrygiannakis D, Hermansson M, Ulfgren AK, et al. Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells. Ann Rheum Dis 2008;67:1488-92.
    • (2008) Ann Rheum Dis , vol.67 , pp. 1488-1492
    • Makrygiannakis, D.1    Hermansson, M.2    Ulfgren, A.K.3
  • 45
    • 73249137735 scopus 로고    scopus 로고
    • Bone remodeling in rheumatic disease: a question of balance
    • Walsh NC, Gravallese EM. Bone remodeling in rheumatic disease: a question of balance. Immunol Rev 2010;233: 301-12.
    • (2010) Immunol Rev , vol.233 , pp. 301-312
    • Walsh, N.C.1    Gravallese, E.M.2
  • 46
    • 0038151908 scopus 로고    scopus 로고
    • Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair
    • van der Pouw Kraan TC, van Gaalen FA, Huizinga TW, et al. Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair. Genes Immun 2003;4:187-96.
    • (2003) Genes Immun , vol.4 , pp. 187-196
    • van der Pouw Kraan, T.C.1    van Gaalen, F.A.2    Huizinga, T.W.3
  • 47
    • 80053576370 scopus 로고    scopus 로고
    • Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis
    • Yeo L, Toellner K-M, Salmon M, et al. Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis. Ann Rheum Dis 2011;70:2022-8.
    • (2011) Ann Rheum Dis , vol.70 , pp. 2022-2028
    • Yeo, L.1    Toellner, K.-M.2    Salmon, M.3
  • 48
    • 82955206481 scopus 로고    scopus 로고
    • Rituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis
    • Boumans MJ, Thurlings RM, Yeo L, et al. Rituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis. Ann Rheum Dis 2012;71:108-13.
    • (2012) Ann Rheum Dis , vol.71 , pp. 108-113
    • Boumans, M.J.1    Thurlings, R.M.2    Yeo, L.3
  • 49
    • 79955566061 scopus 로고    scopus 로고
    • Rituximab treatment induces the expression of genes involved in healing processes in the rheumatoid arthritis synovium
    • Gutierrez-Roelens I, Galant C, Theate I, et al. Rituximab treatment induces the expression of genes involved in healing processes in the rheumatoid arthritis synovium. Arthritis Rheum 2011;63:1246-54.
    • (2011) Arthritis Rheum , vol.63 , pp. 1246-1254
    • Gutierrez-Roelens, I.1    Galant, C.2    Theate, I.3
  • 50
    • 84860561645 scopus 로고    scopus 로고
    • Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin
    • Harre U, Georgess D, Bang H, et al. Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest 2012;122: 1791-802.
    • (2012) J Clin Invest , vol.122 , pp. 1791-1802
    • Harre, U.1    Georgess, D.2    Bang, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.